European Journal of Molecular & Clinical Medicine

Objective: The objective was to assess serum vitamin D [25(OH)D] levels in patients with acne vulgaris and investigate the possibility of a relationship between low serum vitamin D levels and acne severity ordinary.

Introduction:Polycystic ovary syndrome (PCOS) is the most common endocrine
abnormality affecting women of reproductive age, but this condition is still not
completely understood. As it is linked with many chronic conditions such as
cardiovascular and diabetes, there is need to identify the condition at the earliest.
Methods: A cross-sectional Community-based study was conducted in urban
Visakhapatnam in November 2020 among 132 adolescent girls aged between 15 to 19
years to study the prevalence of PCOS among adolescents to identify the risk factors for
polycystic ovarian syndrome. Multistage sampling was used to select the study
participants from six urban zones, information collected using a PCOS validated
questionnaire modified to suit locally. Diagnosis of PCOS was based on
Rotterdam/ESHRE criteria examination for obesity, hirsutism, acne and acanthosis.
Results: Six percentof the study subjects were found to have possible diagnosis of
PCOS. Family history of risk factors for PCOS such as maternal menstrual
irregularities, diabetes and obesity was found in 12.1% of study subjects.Increased BMI
was seen in 6.8% girls and 24 .1% had abnormal menstruation.
Conclusion:Family history, increased BMIand presence of clinical findings as abnormal
growth of hair and acne are found to be significantly associated.

BACKGROUND: -
                         Acne Vulgaris is an extremely common disorder.More than ninety percent of the patients with acne vulgaris suffer scarring leading topsychological impact and cosmetic disfigurement after healing of their acne lesions.Atrophic acne scars are more common and difficult to treat .These can be sub-classified into icepick, rolling and box car depending on their width, depth and shape. Microneedling device performs acne scar remodelling via collagen induction therapy. Autologous platelet-rich plasma therapy combined with micro needling is a new adjuvant treatment modality of the wound healing cascadebased on the body self-healing mechanisms.
                         OBJECTIVE-:
                          Assesment of safety and efficacy of autologus platelet rich plasma therapy combined with  microneedling on atrophic acne scars.
METHODS: -
46 patients with acne scars of 18-25 years age group underwentthree consecutive sittings of  microneedling combined with PRP procedure, conducted  at an interval of 4 weeks followed by a last assessment done after 3 months of final sitting.
The lesions were classified on Goodman’s qualitative scale and serial photography.
RESULTS:
Two independent dermatologists performed evaluation and follow up at subsequent visits. Majority (34) patients with good response (improvement by Grade 1) constituting to (73.91%) in total. There was an overall improvement in 86.9% of cases without any serious complications.
CONCLUSION: -
Autologus PRP combined with Microneedling is an effective modality in enhancing clinical outcomes and overall cosmetic appearence of acne scars.