Online ISSN: 2515-8260

Keywords : Cholesterol

Formulation and Evaluation Studies of Glimepiride Loaded Niosomes

Rohit Kumar; Shefali Srivastava; Utkarsh Verma; Nidhi Bhatt

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2315-2321

The management of infectious diseases and immunization has experienced a transformative
change in recent years. The advent in biotechnology and genetic engineering has created a
number of disease-specific biological. However the focus on successfully delivering
thesebiological is a challenge. Niosomes are vesicles made of non-ionic surfactants that are
biodegradable, non-toxic, more durable, and less costly. In the present work, Glimepirideentrapped
niosomes were produced utilizing an ether injection method with various
cholesterol (CHOL) and Span-60 ratios (1:1, 1:2, and 1:3). In this analysis, the ether injection
approach to insert Glimepiride into niosomes was investigated. In the case of ether injection
process, the prepared niosomesranges from 0.662 to 1.713 μm in size. In-vitro release tests on
Glimepiride niosomes displayed 98.3% release for formulations prepared with CHOL: Span-
60 (1:1) and a release duration of 0 to 24 hours. It has been observed that with the increase in
concentration of Span-60, the order of encapsulation quality had improved. The impact of
varying non-ionic surfactant and cholesterol composition on properties such as zeta potential,
drug quality, vesicle scale, and drug release were tested in an assessment analysis. Based on
the findings of this study, it is possible to infer that the developed noisome formulation of
Glimepiride has considerable potential in the treatment of diabetes due to its prolonged

Monocrotophos toxicity induced hormonal and biochemical disruption in liver and ovary of Cyprinus carpio communis

Sarabjeet Kaur

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 3015-3022

The organophosphorus pesticide, monocrotophos induced toxicity in fish’s adobe has been studied to access the biochemical and hormonal disruption caused in the liver and ovary of the fish. Monocrotophos pose serious risk to biochemical parameters, enzyme activities and level of hormones in the fishes. A direct relationship between concentrations of monocrotophos, elevated cholesterol levels and depressed estradiol concentrations have been traced in the study. The elevated levels of cholesterol in the ovary apparently reflect the reduced rate of its utilization for steroid synthesis by the ovary as significant effect of pesticide. The decreased estradiol level causes decreased production of vitellogenin as well as hampers the development of oocytes in ovary of Cyprinus carpio communis which was also evident in the experiments

Prevalence Of Gallstone In Relation To Age, Sex And Body Mass Index In Tikrit City

Meqdam A. Khalaf; Abdulhadi M. Jumaa; Ammar L. Hussein

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 418-423

gallstones are common diseases in many countries of the world , and incidence rate may reach about 20 % .Most cases of gallstones occur in females , the incidence rate may reach four times to one in comparison between women and men , mainly in fatty , fertile , age of forty female , gall stones are rare before age of 20 years ,but; may occur at any age . many cases are not diagnosed because they do not cause any signs or symptoms , and thus can only be diagnosed accidently by routine abdominal ultrasound.
The aim of study is to evaluate the relationship between age,sex and body mass index as risk factors for gallstone.
a cross sectional study was conducted in Tikrit city during the period from early of May to the end of October 2019 . 468 were enrolled in present study , and only 95 patients were diagnosed as a case of gallstone (29 male , 66 female). All patients attending private ultrasound clinic with different complains, data was collected by using certain questionnaire.
The results showed that, There was highly significant statistical relationship (P – value ≤0.05) between body mass index mean in both gallstone cases(26.628±5.808) and, in cases without gallstone(22.225±1.316). In the present study there was high statistically significant relation(P- value ≤ 0.05) between body mass index measurement above 25(31.97727273± 3.747859149) and measurement below 25(21.85882353± 1.616313889) in patients with gallstone.
The present study conclude that , Body mass index more than 25 considered as an important risk factor for gallstone.

Distribution Of Metabolic Syndrome Components In Patients Younger Than 50 Years Of Age Of Indian Population

Dr. Inder pal Singh; Dr. Kamaldeep kaur; Dr. Lovleen Bhatia; Dr. Ajay pal

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 4786-4793

Background: Prevalence of the metabolic syndrome (MetS) is associated with increased risk of cardiovascular disease and diabetes. Present study aimed to assess the frequency distribution of various components of metabolic syndrome in patients younger than 50 years of age.
Materials and method: The study group consisted of 100 patients less than 50 years of age admitted at Rajindra Hospital with acute coronary disease.
Results: Most common age group was 45-50 years in both males and females, with 66% patients belongs to this age group. 37 patients of ACS with MS, most common component in males was raised blood pressure (SBP and DBP), in females most common component was impaired fasting plasma glucose (FPG). Waist circumference was statistically significantly raised in patients of ACS with MetS as compared to patients of ACS without MetS. Systolic blood pressure (SBP) was statistically significantly raised in patients of ACS with MS as compared to patients of ACS without MS. Systolic blood pressure (SBP) was statistically significantly raised in patients of ACS with MetS as compared to patients of ACS without MetS. Fasting plasma glucose (FPG) Serum triglycerides(TGc) and Serum high density lipoproteins (LDL) was statistically significantly raised in patients of ACS
Conclusion: All the five components of metabolic syndrome i.e. waist circumference, systolic blood pressure, fasting plasma glucose, serum triglycerides, serum high density lipoproteins were significantly associated with patients of acute coronary syndrome with metabolic syndrome as compared to patients of acute coronary syndrome without metabolic syndrome.

Preparation Of Prophylactic And Therapeutic Dietary Preserves On The Basis Of Caper Fruits

Ergashev Oybek Karimovich; Abdulaziz Eshonturaev Abdulatib ugli; Ochilov Golibjon Mamayunusovich

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1541-1547

Capparis Spinosa L. is a medicinal plant and is used in the treatment of various diseases from canned products prepared in combination with its processed fruit buds, processed fruits and other ingredients considered dietary. The technology of dietary canned food made on the basis of caper fruit, which has therapeutic and prophylactic properties, has been developed, the chemical composition has been determined, and safety has been ensured. On the basis of theoretical studies, regimes of complete killing of microorganisms that spoil the caper and make it unfit for consumption have been found, optimal parameters of the sterilization process have been recommended. The optimal technology of canning capers is proposed.