Online ISSN: 2515-8260

Keywords : isatin-3-thiosemicarbazone

Synthesis, Characterization and anti-tubercular activity of substituted thiosemicarbazones and their Ni(II) complexes

Qurat Ul Ain, Sheikh Insha, Rekha Sharma

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3208-3214

Complexes of substituted isatin-3-thiosemicarbazones (H2itsc-N1-Me, H1L; H2itsc-N1-Ph, H2L)
and substituted indole-3-thiosemicarbazone (HIntsc-N1-Ph, H3L) with Ni (II) and
triphenylphoshine of formula, [NiCl(L)(Ph3P)] (anionic form of L = 1L, 1; 2L, 2, 3L, 3) have
been synthesized. The ligands and complexes have been characterized using spectroscopic
techniques (IR, 1H NMR). 1HNMR of complexes supports binding of thio- ligands in anionic
form. All the ligands (H1L – H3L) and their complexes were evaluated for their antitubercular
activities. The enhancement in anti-TB activity of ligands on complexation with Ni(II) has
been observed.