Keywords : Following a reported method with slight modification 2
Methoxy and 8-Methyl Substituted 3-Amino-2-Alkyl/Aryl- 3,4-Dihydro-4-Oxoquinazolines and their 2,4-DNP Derivatives Synthesis
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 1, Pages 4523-4527
Quiazolinesexpecially 4-oxoquinszolines are physiologically active compounds possessing
various biological and pharmacological activities. The physiological and pharmacological
activity in the naturally occuringquinazolines and in most of the synthetic products was
found to be due to the 4-oxo moiety present in them. 3-Amino-2 methyl-3,4-dihydro-4-oxo
quinazolines was first prepared by Bogert and Seil. Out of the various synthetic routs
available, Klosa's method of preparing such amino methylxoquinazolines from
3,1,4benzoxazones with Lal'smodification appeared more attractive to us, owing to its
simplicity and convenience of not isolating the intermediates with good yields.
Furthermore mechanistic investigation of this reaction by Erredeet al. prevented any
pitfalls for us.
Klosa's method with Lal's modification was used to prepare a number of 8-methyl/
methoxy substituted 3-amino-2-alky/aryl-3,4 dihydro-4-oxoquinazolines.