Online ISSN: 2515-8260

Keywords : diabetic nephropathy


SERUM CYSTATIN C AS AN EARLY DIAGNOSTIC MARKER FOR THE DETECTION OF NEPHROPATHY IN TYPE 2 DIABETES MELLITUS

Dr. P.Jayakala, Dr. J S Mounika

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10424-10429

One of the most common causes of dialysis is diabetic nephropathy (DN), which can be
prevented or delayed with early identification. When it comes to chronic kidney disease (CKD)
and type 2 diabetes, little is known about the renal function marker serum cystatin C (sCysC) and
its link to glomerular filtration rate. In this study, we tested the efficacy of sCysC as a marker of
early DN and CKD in patients from the southern Indian coastal region

SERUM TOTAL SIALIC ACID AND HS –CRP (HIGH SENSITIVE C-REACTIVE PROTEIN) AS MARKERS OF DIABETIC NEPHROPATHY

B Sheshu Kumar, Mohammed Rafi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11557-11573

Background:Diabetes mellitus has become a global pandemic and is estimated that it will be the leading cause of death as a non communicable disease by 2030.Diabetic nephropathy is a major long-term complication of diabetes mellitus (DM). Type 2 DM is frequently associated with an underlying low grade inflammatory mechanism , but less information is available on the relationship explaining the low-grade inflammation process and development of diabetic nephropathy (DN). The aim of this study is to determine the serum level of high sensitivity C-reactive protein (hsCRP) ,an acute phase reactant and Serum Total Sialic acid levels, a marker of excessive glycation in unregulated glycemic control in Diabetes mellitus patients leading to the complication of diabetic nephropathy .And to compare with the normal subjects and also to study the association between serum hsCRP levels and Serum Total Sialic acid levels.
Materials and Methods: 50 patients with Type 2 DM with nephropathy (DN) and 50 patients of Type 2 DM without nephropathy (DM) along with 50 unrelated age and sex- matched healthy controls were included in the study. Plasma fasting and postprandial glucose levels, renal profile (serum creatinine, BUN), and lipid profile, HbA1c and Urinary Microalbumin levels were analysed. Serum TSA test levels and hs-CRP level were evaluated using thiobarbituric acid assay and immunoturbidimetric kit methods respectively.
Results: We observed a higher concentration of Serum Total Sialic acid levels (83.2 ± 6.8 mg/dl) and hs-CRP (3.22 ± 1.48 mg/L) in diabetic nephropathy than the diabetes mellitus group (74.1 ± 6.2 mg/dl and 2.2 ± 1.40 mg/L, respectively). Both Serum Total Sialic acid levels and hs-CRP levels were found significantly correlated with plasma fasting and postprandial blood sugar, hemoglobin A1c, and urine microalbumin levels in both DM and DN groups. Multiple logistic regression analysis showed that both TSA and hs-CRP was independently associated with diabetic nephropathy.
Conclusion: High serum TSA and hs-CRP levels suggests the underlying inflammatory mechanism in the development of microangiopathic complications of T2DM like diabetic nephropathy.

Frequency of Diabetic Nephropathy in Diabetic Children and Adolescents at Children Hospital of Zagazig University

Shimaa Saad Mohammed Emam, Rabab Mohammed El -Behiedy,Aml Saeed Elshal, Mayy Abd-AlFatah Mohammed

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2850-2861

Background:Diabetic kidney disease (DKD) is defined as kidney disease attributed
to diabetes. Diabetic nephropathy (DN) is a common micro vascular complication
of diabetes .DN develops in 15-20% of subjects with T1DM and in similar or higher
percentage of T2DM patients, causing increased morbidity and premature
mortality. American Diabetes Association (ADA) recommends screening for
nephropathy 5 years after diagnosis for type 1 diabetes and at diagnosis for type 2
diabetes.Aim: To estimate the occurrence of diabetic nephropathy in children and
adolescent diagnosed with diabetes Method: A case control study was carried on
one hundred and fifty of children went to pediatrics clinics of zagazig university
hospital. They were classified in to 75 diabetic children who were type 1DM for
more than 4 years and their age less than 18 years old and 75 non diabetic children
of the same gender and age. Both groups under go full history, clinical and
laboratory investigations during the period from December 2018 to November 2019.
Result: frequency of persistent microalbuminuria and hypertension among diabetic
patients were 293 per 1000 and 160 per 1000patient respectively.Conclusion: Type1
diabetic children and adolescent are liable for the occurrence of early diabetic
nephropathy so intensive diabetes therapy is needed, regular screening for MA and
measurement and interpretation of BP and GFR