Online ISSN: 2515-8260

Keywords : SEM

Formulation and Evaluation Studies of Glimepiride Loaded Niosomes

Rohit Kumar; Shefali Srivastava; Utkarsh Verma; Nidhi Bhatt

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2315-2321

The management of infectious diseases and immunization has experienced a transformative
change in recent years. The advent in biotechnology and genetic engineering has created a
number of disease-specific biological. However the focus on successfully delivering
thesebiological is a challenge. Niosomes are vesicles made of non-ionic surfactants that are
biodegradable, non-toxic, more durable, and less costly. In the present work, Glimepirideentrapped
niosomes were produced utilizing an ether injection method with various
cholesterol (CHOL) and Span-60 ratios (1:1, 1:2, and 1:3). In this analysis, the ether injection
approach to insert Glimepiride into niosomes was investigated. In the case of ether injection
process, the prepared niosomesranges from 0.662 to 1.713 μm in size. In-vitro release tests on
Glimepiride niosomes displayed 98.3% release for formulations prepared with CHOL: Span-
60 (1:1) and a release duration of 0 to 24 hours. It has been observed that with the increase in
concentration of Span-60, the order of encapsulation quality had improved. The impact of
varying non-ionic surfactant and cholesterol composition on properties such as zeta potential,
drug quality, vesicle scale, and drug release were tested in an assessment analysis. Based on
the findings of this study, it is possible to infer that the developed noisome formulation of
Glimepiride has considerable potential in the treatment of diabetes due to its prolonged


Pavan Kalyan Reddy C.P; Roji Marjorie

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 2448-2451
DOI: 10.31838/ejmcm.07.10.261

To prepare a novel Bio sensor for ethanol vapour detection with higher sensitivity. In this Zn(Mn)/ZnO inverted core shell structure is doped in starch. Add a noble metal foe the better response. After this making thin films and determine the thickness of a thin films. Dielectric constant is determined by using the LCR meter. The characterization is done by using XRD, SEM, and the sensing properties of ethanol sensor are based on the resistance-based sensing

Factors Related To Hiv/Aids Knowledge Of Eligible Women

Dhesi Ari Astuti; Nur Rahman Dzakiyullah Dzakiyullah; Linda Yulyani; Claudia Banowati Subarto

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 57-69

Data from Indonesia Demographic and Health Survey (IDHS) 2017 show the increase on the knowledge of prevention for HIV/AIDS among Women (49%) and married Men (55%). However, the factors that influence the increase of knowledge in the community, especially among eligible women (EW) are still unknown. On the other side, to increase the number of HIV voluntary counselling and testing (VCT) requires a good knowledge from community, so it is important to identify what factors that are related to HIV/AIDS knowledge. Therefore, this study aims to determine the factors associated with HIV/AIDS knowledge among EW.
This is a cross-sectional study using secondary data from IDHS 2017 (data couples record). Data were analysed using the Structural Equation Modelling (SEM). This study analyses the relationship between predisposing, enabling and reinforcing factors with the HIV/AIDS knowledge of EW.
The results show that more than 75% of 8.838 EW had less knowledge about HIV/AIDS. There are 73.1% of respondents who have mobile phones, but only 4.9% of respondent access information about HIV / AIDS via the internet. In addition, there are 32.2% of respondents who have an elementary school education level or have no education attainment. From the results of PLS-SEM analysis, it is known that the education level and wealth index of EW are predisposing factors that influence EW’s HIV/AIDS knowledge (p-value = 0,000). The frequency of reading the newspaper and the possession of mobile phone are the enabling factors that influence EW’s HIV/AIDS knowledge (p-value = 0.025). Meanwhile, the factors of health workers and community meetings are the reinforcing factors related to EW’s HIV/AIDS. Therefore, health promotion is needed to increase the number of women in continuing education, completing secondary education to higher education, and the innovation to use information technology to disseminate information about women's reproductive health to the community.

Perception Of Rice Farmers Towards The Role Of Agricultural Extension Worker In Changing Behaviors To Follow Up Extension Activities , In Magelang District , Central Java, Indonesia

Setyo Rahyunanto; Sunarru Samsi Hariadi; Roso Witjaksono

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4987-4999

Agricultural extension is generally understood as an activity to disseminate agricultural information and guide farming. The role of extension worker as agents of reform is very important for community empowerment activities, especially for farmers, either individually or who are members of farmer groups / Gapoktan. The roles of extension workers include being a facilitator, motivator, mediator, educator and as a supporter of farming activities . This research aims to analyze the effect of rice farmers' perceptions on the role of agricultural extension agents and their impact on the attitudes, feelings and behavior of rice farmers. in following up on the results of counseling . The research method used a quantitative method approach with the number of respondents 218 rice farmers who were taken by simple random sampling analyzed using SEM at α = 0.05. The results showed that perceptions did not have a significant direct effect on farmer behavior in following up extension activities. However, perception has a significant effect on attitudes that have an influence on behavior. In addition, perception also affects feelings, but feelings do not show a significant effect on behavior. P Felling trees trimming logs rice has a pretty good perception of the role of agricultural extension as a facilitator, educator, mediato r and motivator .
To enhance the role of agricultural extension worker, the extension must master the material and their counseling practice, so there should be training or training in accordance with the needs of extension. Prior to the training, it is necessary to conduct research on what extension agents have not mastered.

An Overview On Structural, Morphological And Optical Properties Of Titanium–Dioxide Nanoparticles

Ansh Gupta; Ankush Thakur

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2815-2818

This review reports the major characteristics associated with titanium–dioxide nanoparticles for different methodology. Titanium dioxide has drawn attention worldwide for large scale manufacturing due to its properties along with nontoxic behavior for various applications. Titanium dioxide is considered as suitable for materials for pollution degradation and helps to promote the rate of photosynthesis. Structural properties were discussed with help of X-ray diffraction that helps to investigate physical characteristics. The estimated crystallite size found to be increase with increase in temperature. Morphological analysis was done with the help of scanning electron microscopy and transmission electron microscopy. The morphological behavior shows the formation of homogeneous spherical nanoparticles and agglomeration obtained for sample calcinated at higher temperature.

Factors that affect the digital banking adoption in Hyderabad city-UTAUT model approach

K.Suma vally; Dr.Ch. Shankar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 857-865

Mechanical developments have encouraged the financial segment to open efficient conveyance channels. Computerized banking is the quickest developing channel of banking therefore few individuals are strolling into bank offices nowadays. Banks presently require waiting applicable by taking into account the necessities and desires for the clients and to the innovation progressions. By offering better types of assistance and items clients can use. Banks depend on a social occasion, handling, dissecting, and giving data to get together the requirements of clients. Given the noteworthiness of data in banking, banks were among the most punctual adopters of robotized data handling innovation.
The enthusiasm behind this examination is to look at the variables which influence the computerized financial acknowledgment of clients in Indian banks by utilizing the adjusted unified hypothesis of acknowledgment and utilization of innovation (UTAUT) model. The presentation hope, encouraging conditions, exertion hope, saw worth, propensity, and epicurean inspiration are taken as autonomous factors. Essentially, the aim to receive Internet banking is taken as the middle person, and real use is utilized as the needy variable.

The role of oxidative stress on molybdenum enzymes and ischemic reperfusion injury in hyperuricaemic patients. An infrared spectroscopic study

Mamareli V; Tanis O; Anastassopoulou J; Kyriakidou M; Mamareli CH; Koui M; Theophanides T; Mamarelis I

European Journal of Molecular & Clinical Medicine, 2019, Volume 6, Issue 1, Pages 20-25

There are many clinical evidences that hyperuricemia is a risk factor for the development of peripheral carotid and coronary vascular diseases. However, the mechanism of elevated uric acid concentration in biological systems is not yet clear. In the present work Fourier transform infrared (FT-IR) spectroscopy was used to evaluate the mechanism of calcification and plaque formation in carotid arteries in hyperuricaemic patients. Comparison between the spectra of carotid arteries from patients with elevated uric acid values and spectra obtained from patients with normal uric acid values showed structural changes of the characteristic spectral bands in the region 4000-500 cm-1. These changes were related with changes in the concentration of the serum uric acid and the clinical history of the patients. The intensity decrease of the infrared bands in the region 1650-1500 cm-1 was associated with the decrease of the apolipoprotein ratio, ApoI/ApoII, which corresponds to HDL (High Density Lipoproteins) and the regulation of the LDL (Low Density Lipoproteins), which are related to oxidation stress. The infrared band at 1467 cm-1 indicated the presence of urea components as a result of the metabolic pathway. The shape and the intensity of the bands between 1250-900 cm-1 depend on the glycation-end products of the diseases. SEM-EDX chemical analysis showed fibril formation and molybdenum release in hyperuricaemic patients.