Online ISSN: 2515-8260

Keywords : breast carcinoma

In a tertiary care centre, the study examined breast cancer risk factors, clinical presentation, and treatment

Sravanthi Yerragolla, T. Spandana, Swathi Cheruku, Bayya Praveena .; Manish Shah, Priyanka .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 3194-3198

Background: The most frequent type of cancer among women is breast cancer. In terms of total cancers, it is ranked second. Many risk factors are linked to it. Breast cancer can manifest itself in a variety of ways, ranging from invasive carcinoma to non-invasive carcinoma.
Aim and objective: To explore the risk factors, clinical presentation, and management of breast cancer, 100 patients with diagnosed breast cancer were evaluated in a tertiary care centre. Data was gathered using a pre-tested questionnaire. Demographic characteristics, clinical presentation, risk factors, and breast cancer management were all collected. Data was evaluated using statistical tests.
Results and discussion: All of the patients had a lump in their breast (100 percent). A lump with pain was detected in 21% of the patients. The most prevalent histopathological type was infiltrating duct carcinoma (97 percent). The majority of the patients (56 percent) were in stage II, followed by stage I. (23 percent). The patient's average age was 52.21±4.6 years. Menarche occurred at an average age of 13.86±1.8 years. The average age of menopause was 46.3±4.31. The average number of months spent breastfeeding was 36.41±5.62. A modified radical mastectomy was provided to 51% of patients, while total mastectomy was offered to 23%.

The profusion of breast lesions in breast biopsies showed imaging and pathological discordance

1Amod Kumar, 2Aashish Gupta, 3Monica, 4Payal Kumari, .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 3286-3293

Introduction: For nonpalpable breast lesions, imaging-guided breast tissue biopsy has become a viable alternative to open surgical biopsy. It can be difficult to talk about abnormal results of the connection between imaging and pathology findings because they can help with decision-making about additional treatment options by arriving at a full diagnosis.
Materials and Methods: This was a retrospective study. A specialist radiologist collected and classified radiological data from 500 patients' imaging-guided breast biopsies over a 6-year period using the BIRADS format. The discordance between histopathology reports was investigated.
Results: A total of 500 cases were reviewed. Approximately 4.6% (23) of cases fell into BIRADS 2 category, 33.6% (168) of cases fell into the BIRADS 3 category, 24.4% (122) into the BIRADS 4, 36.6% (183) into BIRADS 5 categories and 0.8% (4) into BIRADS 6 categories. Approximately 49.2% (n = 246) cases were benign, 3.4% (17) belonged to the high‑risk category, and 47.4% (237) were malignant. The number of discordant cases was 12 (2.4%), mostly due to technical factors. The sensitivity of biopsies to detect malignancy was 85%, specificity was 96%, and accuracy of biopsy in diagnosing cancer was 90%.
Discussion: The most sensitive way for detecting early breast cancer is the "triple assessment." Because of the high occurrence of carcinoma in these lesions, an effective communication line between a physician, radiologist, and pathologist is required for surgical excision in discordance.
Conclusion: In discordant cases, the ultimate choice is based on two concordant findings out of the three parameters, either due to abnormal imaging results or abnormal pathology findings. A multidisciplinary breast conference is held, with the pathologist taking an active role.

A clinicopathological study of breast cancer in elderly women at a tertiary care hospital

Dr. Shantkumari B, Dr. Maktum Naik, Dr. Jairaj Bhaskar

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2058-2064

Breast cancer is the most common cancer in women worldwide and the second most common cause of cancer related deaths in women. Incidence of breast cancer is increasing with age as there is improvement in survival rate. It has attracted considerable interest in the study of carcinoma breast in elderly. Study was conducted on all the clinically diagnosed cases of breast cancer in the elderly women aged above 60years. Data was collected from the patient after obtaining a written informed consent. Detailed history, clinical examination and relevant laboratory investigations were done and clinical diagnosis confirmed perioperatively and postoperatively based on histopathological examination in the elderly patients. 4(8%) patients presented with clinical T1 stage, 22 (44%) patients presented with T2 Stage, 15 (30%) patients with T3, 5(10%) patients with T4a and 4 (8%) patients with T4b tumor status. 25 (50%) patients had clinically N0 Status at presentation. 20 (40%) patients were N1 at presentation, 5(10%) patients presented with N2 nodal status and 1 (2%) patients with N3 status. Infiltrating ductal carcinoma was the most common histological variant constituting 22 (44%) of the population. Clinico pathological features and treatment vary in elderly compared to young patients, Infiltrating ductal carcinoma is the most common histological variant of breast cancer seen.

Interleukin-10 Gene Expression and Haematoxylin and Eosin staining in Breast Carcinoma

Dr. A Ksheera Cariappa, Dr. Atchyuta Mathi, Dr K. Varalakshmi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 719-730

In India breast cancer is the 2nd most common cancer in women after cervical
cancer and is associated with high mortality and morbidity. Role of IL-10 in cancer though, well
accepted, is vaguely understood. IL-10 is known to exhibit both pro and anti-tumour activities.
Polymorphism in interleukin genes are thought to influence the expression or function of these
proteins. Hence our study was designed to evaluate the role of low penetrant interleukin-10 (IL-
10) gene and its influence on tumorigenesis.

Assessment of the D-Dimer Levels and their Correlation with Lymph Node Involvement in Carcinoma Breast

Dr. Gaurav Kataria; Dr Preeti Juneja

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 8840-8844

Background:Mammography is a widely used screening approach in the detecting of breast
cancer and proved to help reduce the mortality effectively. D-dimer (or D dimer) is a fibrin
degradation product (or FDP), a small protein fragment present in the blood after a blood
clot is degraded by fibrinolysis. Hence; the present study was undertaken for assessing the
d-dimer levels in carcinoma breast.Materials & methods:A total of 25 breast carcinoma
patients were enrolled.Data was collected using self-structured Performa which consisted
of detailed history, thorough examination, investigations and results. Blood venous
samples (3 ml) were collected from all patients before any surgical intervention, and
clinical staging was done. All the results were recorded and analysed using SPSS software.
Results:Mean D Dimer levels were found to be 2.458 μg/mL.Mean D-Dimer levels among
patients with and without lymph node involvement was 2.896 μg/mL and 1.354 μg/mL
respectively. Significant results were obtained while comparing the mean D-Dimer levels
among patients with and without lymph node involvement.Conclusion:D-dimer was found
to be an independent predictive factor for lymph node metastasis. However; further studies
are recommended.