Online ISSN: 2515-8260

Keywords : Leiomyoma

Histopathological correlation of hysterectomy specimens with clinical and other investigational findings

Dr. Killol Nathubhai Desai, Dr. Vidya Satapara, Dr. Alpeshkumar Maheshbhai Maru, Dr. Harshid L. Patel

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1040-1048

Context: Hysterectomy is the surgical removal of the uterus and is the most common major
gynaecological surgical procedure performed worldwide.
Aims: To study the incidence and distribution of various types of pathologies in the
hysterectomy specimens in the population studied.
Methods and Material: A total of 500 cases were studied. The study material was obtained
from patients’ hospitals that underwent hysterectomy and also specimens sent from nearby
private or government
Results: Among various significant pathologies, benign accounted for 95.7% of lesions while
malignant for 4.3% of lesions. Among benign lesions, adenomyosis was commonest with 203
(136 isolated + 67 with leiomyoma) cases and it was most common in 41-50 years age group.
Leiomyoma was next common with 183 (116 isolated + 67 with adenomyosis) cases and it
was also most common in 41-50 years age group. 67 (13.4%) cases had both leiomyoma and
adenomyosis. CIN1 or LSIL accounted for 15 cases, serous cystadenoma of ovary for 12
cases, endometrial polyp for 12 cases, mature cystic teratoma of ovary for 8 cases,
endocervical polyp for 9 cases, cervical leiomyoma for 6 cases, mucinous cystadenoma for 3
cases, placenta accreta for 3 cases, simple endometrial hyperplasia without atypia for 2 cases,
infected decidua for 2 cases, CIN2/CIN3 or HSIL for 2 cases, adult granulosa cell tumour for
2 cases, endometriosis of ovary for 2 cases, broad ligament leiomyoma for 2 cases, acute
salpingitis for 1 case, endometriosis of fallopian tube for 1 case, complete hydatidiform mole
for 1 case, invasive hydatidiform mole for 1 case and adenomatoid tumour of myometrium
for 1 case. Among malignant lesions, carcinoma of cervix was commonest with 11 cases,
followed by carcinoma of ovary with 7 cases and carcinoma of endometrium with 3 cases.


Dr Kunal Aher,Dr Snehal B Shinde,Dr Saudamini A. Naik,Dr Amit S Naik, Dr Mrunmyee Hemane

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5223-5231

Objective: The aim of the study wasto evaluate the validity of Transvaginalsonography(TVS) in
accurately diagnosing structural pathologiesin patients with the perimenopausal AUB (PALM
component of PALM COIEN classification) and to assess the degree of agreement between the
Transvaginal ultrasonographic(TVS) and Histopathological(HPR) findings.
Material and Method: This retrospective study was conducted in 102 women with
perimenopausal AUB attending the tertiary rural health center in North-west Maharashtra. Indoor
case records of 102 perimenopausalwomen with AUB who were subjected to TVS and later
diagnostic fractional curettage and /or hysterectomy as per institutional protocol, and in whom
HPR examination reports were available were included in study. Data was collected and
tabulated as per ethically approved format. Kappa Statistical test and Z test of difference between
proportions was applied to assess the degree of agreement between the TVS and HPR findings
Results:In the present study 36% Leiomoyoma, 24% Endometrial Hyperplasia & 10%
Adenomyosis were diagnosed as cause of Perimenopausal AUB on TVS. However on HPR
examination 41% Endometrial Hyperplasia,33% Leiomoyoma,,16% Adenomyosis & 5%
malignancies were responsible for AUB. TVS had 97% specificity, 50% sensitivity& 92%
Positive predictive value(PPV) in diagnosing Endometrial hyperplasia .TVS had 89%
specificity& sensitivity and 92% Negative predictive value(NPV)to diagnose Leiomyoma.
Kappa test and Z test showed statisticallygood coorelation over chance for leiomyoma andFair
coorelation over chance for diagnosing Endometrial Hyperplasia

Role of MRI in detecting female infertility

Dr. A Antony Jean,Dr. K. Karthikeyan,Dr.Ajit Kumar Reddy, Dr.AnnithaElavarasi J

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3197-3201

To assess role of MRI in detecting female infertility.
Materials & Methods:Eighty- six women age ranged 20- 40 years were included in the
study. All underwent MRI using 1.5 Tesla unit equipped with a 32 phased-array surface
coil. Causes of female infertility was recorded.
Results: Age group 20-30 years comprised of 50 and 31-40 years had 36 patients. Various
causes of female infertility was PCOS in 12, tubal disease in 18, pelvic inflammatory
disease in 10, endometriosis in 8, leiomyoma in 6, adenomyosis in 12 and endometrial
polyps in 20 cases. A significant difference was observed (P< 0.05).
Conclusion: MRI is an excellent non-invasive, radiation-free modality for the evaluation
of female infertility; its superior soft-tissue contrast resolution and multiplanar evaluation
generate exquisite anatomical details.