Online ISSN: 2515-8260

Keywords : Cervical cancer


A MULTIFACETED TACTIC FOR DETECTION OF CERVICAL CANCER USING EXTREME LEARNING MACHINE WITH CROW SEARCH OPTIMIZATION CLASSIFICATION

Geetha .; S. Suganya

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 934-944

Malignancy or carcinoma is the unrestrained development of cells. There are numerous kinds of malignancies. In this, we are concentrating on one of the normal tumor of females is malignant growth of the cervix. Cervical cancer is the second most kind of malignant growth found in females, apart from the breast cancer which is first existence. There are abundant quantities of screening tests for Cervical cancer in which Pap smear has done. Pap smear is a virtuous device for first screening of this cancer yet it has constraints as there are consistently odds of blunder due to human perceptions. The main aim of this research is to preclude failures by utilizing computerized methods for identifying the cervical cell. Here, the image of Pap smear has been improved by utilizing Kaun Filter. The weight factor in kaun filter is resolved using an optimization technique called Bayesian Optimization Algorithm. Thus it tends to be an upgraded KF. The reformed picture has been segmented by Active Contour model. In this, the weight upgrade issue has been rectified using Analytic Hierarchy Process optimization technique. Hereafter, the solid features are eliminated from the segmented region which is most significant for identifying the cancer by utilizing ELMCSA (Extreme Learning machine with Crow Search optimization) classifier. Experimental results for the cervical cancer identification by the proposed ELM-CSA outperforms 93.5% of accuracy, 88.7% of specificity,79.21% of precision,92.25% of recall and 79.26% of F-measure than the existing classifiers such as ELM, ENN-TLBO, SVM and RBFN

The Use Of Sonication Method For Reducing Size Of Liposomes In Papaya Leaf Extract (Carica Papaya Linn) Preparations As A Candidate In Treatment Of Cervical Cancer

Yuly Peristiowati; Sandu Siyoto; Koesnadi .; Arina Chusnatayaini; Hariyono .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 4703-4709

Liposomes are vesicle-shaped particles whose walls are composed of lipid molecules ( the main constituent is a double layer phospholipid which wraps the liquid compartment inside. Liposomes can be made from natural ingredients in the form of natural phospholipid derivatives mixed with fat chains (eg phosphatidylcholine) by dispersing. Liposomes from papaya leaf extract (Carica Papaya Linn) are made with the aim of increasing the effectiveness of the drug and biocompatible work, as well as protecting healthy tissue from the toxic effects of the drug. The process of making liposom papaya leaf extract using the sonication method by mixing soybean lecithin with papaya leaf extract. Then do the heating and sonication. This method is done to reduce particle size. The aim of this study was to produce an extract of liposomes from papaya leaf phospholipid formulations using a combination of heating and sonication. The method to produce liposomes with a size of <150 nm using a combination of heating 40○C for 40 minutes and stirring using ultraturrax at a speed of 15,000 rpm for 30 minutes, then stirring with a sonicator for 30 minutes. The results showed the liposome nano papaya leaf extract formulation from soybean lecithin by the PSA (Particle Size Analyzertype 1090 / Cilas) method. The liposome product was in the form of liquid, light green and milk white and odorless. Particle size distribution is obtained in the range of 0.04 μm - 500.00 μm / 100 Classes and an average pH of 5.45.

Utilization pattern of various cervical cancer screening methods and their outcomes among patients visiting outpatient department of tertiary care hospital Running title: Cervical cancer screening methods

Dr. Anima Prasad; Dr. Amrish Kumar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1006-1010

Background: The present study was conducted to assess utilization pattern of various cervical cancer screening methods and their outcomes among outpatients of tertiary care hospital.
Materials & Methods: 140 women age ranged 20-50 years were recruited. A questionnaire was developed and distributed among all subjects and asked to fill it and return it. Awareness and utilization and pattern of cervical screening was noted.
Results: Age group 20-30 years comprised of 40, 30-40 years had 60 and 40-50 years had 40 subjects. Education level was upto primary in 65, secondary in 45 and no education in 30 subjects. 90 were married, 25 unmarried and 15 were widow. 98 had awareness and 42 had never heard about it. 55 utilized it and 85 never utilized it. The difference was significant (P< 0.05). The type of methods of screening was PAP’s smear in 15, VIA in 35, VILI in 10, frequency of screening was yearly in 35, once in 20 and never in 85. Accessibility to results of screening was 25 received results of screening, 10 not received results of screening and 20 did not indicate receipt of results of screening. The difference was significant (P< 0.05).
Conclusion: Authors found that there was lack of awareness and utilization of cervical screening among subjects. Most commonly used methods was visual inspection with acetic acid.

The Use of Sonication Method For Reducing Size of Liposomes In Papaya Leaf Extract (Carica Papaya Linn) Preparations As A Candidate In Treatment of Cervical Cancer

Yuly Peristiowati; Sandu Siyoto; Koesnadi .; Arina Chusnatayaini; Hariyono .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 5, Pages 1011-1016

Liposomes are vesicle-shaped particles whose walls are composed of lipid molecules ( the main constituent is a double layer phospholipid which wraps the liquid compartment inside. Liposomes can be made from natural ingredients in the form of natural phospholipid derivatives mixed with fat chains (eg phosphatidylcholine) by dispersing. Liposomes from papaya leaf extract (Carica Papaya Linn) are made with the aim of increasing the effectiveness of the drug and biocompatible work, as well as protecting healthy tissue from the toxic effects of the drug. The process of making liposom papaya leaf extract using the sonication method by mixing soybean lecithin with papaya leaf extract. Then do the heating and sonication. This method is done to reduce particle size. The aim of this study was to produce an extract of liposomes from papaya leaf phospholipid formulations using a combination of heating and sonication.The method to produce liposomes with a size of <150 nm using a combination of heating 40○C for 40 minutes and stirring using ultraturrax at a speed of 15,000 rpm for 30 minutes, then stirring with a sonicator for 30 minutes.The results showed the liposome nano papaya leaf extract formulation from soybean lecithin by the PSA (Particle Size Analyzertype 1090 / Cilas) method. The liposome product was in the form of liquid, light green and milk white and odorless. Particle size distribution is obtained in the range of 0.04 μm - 500.00 μm / 100 Classes and an average pH of 5.45.

Knowledge And Practice Of Preventive Control Of Cervical Cancer In Housewives

Juvita D. Soto-Hilario .; Silvia A. Martel-y- Chang; Holger A. Aranciaga- Campos; Abner A. Fonseca- Livias

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3975-3984

Objective. To determine the relationship between knowledge and the practice of preventive control of cervical cancer. Methods. A correlational study was carried out with 120 housewives attending the CLAS Pillcomarca in Huánuco 2017. In the data collection a knowledge questionnaire and a practice questionnaire were used. For the inferential analysis of the results, the Chi Square Test of independence was used. Results. 50.0% (60 housewives) presented regular knowledge about cervical cancer and 90.8% (109 housewives) had preventive cervical cancer control practices. On the other hand, a significant relationship was found between the knowledge about cervical cancer and preventive control practices (p 0,000). And, the general knowledge of the disease and knowledge about the prevention of the disease relate to the preventive control practices of cervical cancer (p 0.000). Conclusions. There is a significant relationship between the knowledge about cervical cancer and the preventive control practices of cervical cancer of housewives attending the CLAS Pillcomarca - Huánuco.