European Journal of Molecular & Clinical Medicine

Network research gives strong access to the entire human brain organisation. It was
applied to characterise the brain communication patterns in combination with graph
theory. Multiple sclerosis (MS) offers new insights into pathological processes within grey
and white matter. It analyses brain networks derived from structural or functional
imaging. In addition to focal lesions and diffuse tissue damage, network connectivity
patterns may be significant in close monitoring and disease prediction. This study explains
the graphical theory principles, highlights new issues related to acute and chronic tissue
reorganisation, and discusses network analysis in MS patients. We also describe functional
and structural communication trends observed in MS from disconnection and disturbance
to modification and compensation. Also, based on current literature, we link network
change and its connection to clinical incapacity. Finally, we explore the network science
perspective in MS for future research and postulate its position in the clinical environment.