Online ISSN: 2515-8260

Keywords : Liver dysfunction

Liver Function Tests to Predict the Severity of Dengue Fever in Serologically Positive Children Below 18 Years of Age

Janardhan Reddy Pulluru, Suraboina Satishkumar, Gajula Ravi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10404-10413

Background:Dengue fever presents with a diverse clinical spectrum. Although liver is
not a major target organ, hepatic dysfunction is a well recognized feature. In this study
we attempted to study the pattern of hepatic involvement in children with dengue and
its association with disease severity.
Materials and Methods: This was a cross sectional study conducted at during the period
of 1 year. Children <18 years of age with dengue Ns1 Ag and IgM positive were
included in this study. After obtaining informed consent, a pre structured proforma was
used to record the relevant information from each subject. After detailed clinical
examination and haematological investigation children were categorized into three
groups as dengue fever with no warning signs(DNWS), dengue fever with warning
signs(DWWS) and severe dengue fever(SDF) according to WHO classification.
Statistical analysis was done to know the strength of association between different
clinical and biochemical variables and outcome of the disease.
Results: The mean age of the study population was 8.65 years with male preponderance.
The mean total bilirubin, serum albumin, SGOT, SGPT, ALP, PT and INR were 0.76
mg/dl, 3.8g/dl, 233.18U/L, 118.15U/L, 200.65 U/L, 12.9s and 1.09 respectively. The mean
SGOT was significantly higher than SGPT. The degree of deranged LFTs was
significantly more in SDF group than DNWS and DWWS groups. Serum albumin was
significantly decreased in children with SDF group correlating with disease severity,
prognosis and outcome.
Conclusion: Hepatic dysfunction was present in all forms of dengue infection, with
SGOT rising significantly more than SGPT. All biochemical liver parameters were
significantly deranged in patients with severe dengue fever indicating prolonged illness
and poor prognosis.


Madepelly Aditya

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11761-11770

Background:Liver dysfunction in dengue varies from mild injury with elevation of transaminases to severe hepatocyte injury. Despite hepatocytes are not a major target, hepatic dysfunction is the recurrent feature. Predictive hepatic serum markers represent a solution for the dynamic care of serious dengue and predicting disease prognosis. In the present study we pursued to mold the mode of hepatic involvement in children with dengue and its association with seriousness of disease.
Materials and Methods: This was a cross sectional analytical study conducted at Department of Pediatrics, Govt Medical College &hospital during the period of 18 months from October 2019 April 2021 on 120 children under 18 years of age diagnosed with dengue positive and similar age and sex matched controls were included in this study. After obtaining informed consent, Patient demographics, presenting symptoms, clinical signs, laboratory parameters such as complete blood count, serum AST, serum ALT, ALP, total and direct bilirubin; serum albumin levels were collected. P-value <0.05 and CI 95% were considered significant in all correlation analyses between transaminases and platelet count.

Alcoholic liver cirrhosis as wellspring for periodontal indisposition: a case control study

Dr. Aruna N. Daware Dr. Shweta S Bhayade, Dr. Indrajeet Deshpande, Dr. Priyadarshani R Sarkate, Dr. Sucheta Narwat

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3491-3499

Aims: To evaluate the effect of alcoholic liver cirrhosis on health of periodontal status.
Methods and Material: A total of 120 subjects were included in the study between the age group of 35 to 75 years of age. A total of 60 patients diagnosed as alcoholic liver cirrhosis (based on AST: ALT = ˃2) were included in the study. A control group of 60 subjects were included which do not have alcohol consumption habit and not having any systemic problems. Periodontal parameters included Plaque index, gingival index, Number of missing teeth, Probing depth and Clinical attachment loss. Statistical analysis: Statistical Analysis was performed using statistical software SPSS version 17. A post hoc test was done for intergroup comparison of periodontal parameters between the test and control group.
Result: The Plaque Index, gingival index, probing depth and clinical attachment loss has shown a statistically significant difference (p=0.000) when compared between test and control groups. There was no statistically significant difference (p=0.045) found in the number of missing teeth between test and control group.
Conclusion: Alcoholic liver cirrhosis can be considered as one of the risk indicator for periodontal diseases which compromises the periodontal health.