Online ISSN: 2515-8260

Keywords : oral

Study of oral manifestations in chronic kidney disease in vindhya Region

Karuna Jindwani , Keshav Singh , Ayush Jain

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 2336-2347

Background: Normal kidney secretes nitrogenous waste product, regulate volume and
acid /base balance of plasma and synthesize erythropoietin, 25-(OH)2- cholecalciferol
and renin. Chronic kidney disease (CKD) is caused by a progressive and irreversible
decline in the number of nephrons. A wide variety of oral manifestations occurs in CKD
patients. Determination and identification of these manifestations will improve the
quality of life in these patients.
Methods: Thus, this cross-sectional study was conducted in the Department of
Medicine, Sanjay Gandhi Memorial Hospital (SGMH), associated with Shyam Shah
Medical College (SSMC), Rewa, in the Vindhya region between February 2019 and
August 2020.
Results: Out of 127 patients, maximum prevalence of oral manifestations occurring was
pallor (93.70%), xerostomia (84.25%), halitosis (72.44%), sore throat (64.56%), lip
pigmentation (63.77%), periodontitis (48.81%). High Urea levels were found to be
highly significant when correlated with halitosis (p<0.00052). Xerostomia was found
significant when correlated with duration of dialysis (<1 year) with p<0.032.
Conclusions: Manifestations of CKD are common during the progression of uremia. In
the patients studied, the impact of CKD on the oral cavity was evidenced by significant
changes, which pointed to an inter-relationship between oral health and CKD.

Evaluation of Serum Interleukin-6 in Lichen Planus

Mohamed Metwalli, MD, Hoda. AIbraheem, MD, Hager Abu bakr MSc. FathiaKhattab MD

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3603-3611

Background: Lichen planus (LP) is animmune mediated inflammatorydiseaseof skin and
mucous membranes without a clear etiology. Interleukin-6 (IL-6) is a pro-inflammatory
cytokinewith variousbiologicaland pathological impactson immunity, acute phase response
andinflammation. ExcessiveIL-6production can play a role in the pathogenesis of several
pathological conditionslike psoriasis.
Aim:This study aimed to evaluate serum IL-6 levels inLP patients alongwithassessment
ofitscorrelation with disease severity.
Patients and methods: Twenty-one adult patients with LP as well astwenty-one healthy adult
controls were enrolled in the study. The total score of LP severity was estimated for all
patientsby calculation of the affected body surface area in cutaneous LP patients and clinical
scoring system with visual analogue scale for pain assessment for oral LP.Serum IL-6 levels
were measured in all participants using enzyme-linked immunosorbent assay.
Results:The mean serumIL-6 levels were significantly higher in patients than controls (P <
.002). A positive correlation wasnoticed between serum IL-6 with both cutaneous LP (P
<0.004) and oral LP (P <0.005) severities.