Online ISSN: 2515-8260

Keywords : Forced swimming test


To examine antidepressant impact of Aloe Vera and Fluoxetine in Mice

Amit Kumar Maurya, Amrita, Bhavana Yadav, Dhananjay Kumar Pandey

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3612-3619

Aim: The current examination was attempted to research the pharmacological screening
of depressant action for hydroalcoholic extract of aloe vera on mice.
Material and Methods: The hydroalcoholic concentrate of aloe vera were make the diverse
measurements type of 150mg/kg and 300mg/kg given to mice (p.o) of test gathering
Fluoxentine 20mg/kg given to mice (i.p) of standard gathering and controlled gatherings
were directed refined water as vehicle (10ml/kg). The idleness time were recorded for six
minutes in creature screening model of constrained swimming test and tail suspension test
model.
Results: In FST model of sadness, mean idleness time in seconds in Fluoxetine (20mg/kg)
treated gathering was 94.00, 92.00 and 90.00 seconds on day first, seventh and fourteenth
day. In Hydro alcoholic concentrate of Aloe Vera (150mg/kg) treated gathering was 88.00,
86.50 and 82.50 seconds on day first, seventh and fourteenth day, while in Hydro alcoholic
concentrate of Aloe Vera (300mg/kg) treated gathering was 81.00, 73.00 and 69.90 seconds
on day first, seventh and fourteenth day. In TST model of melancholy, mean fixed status
time in seconds in Fluoxetine (20mg/kg) treated gathering was 100.015, 95.50 and 90.00
seconds on day first, seventh and fourteenth day. In Hydro alcoholic concentrate of Aloe
Vera (150mg/kg) treated gathering was 96.885, 93.50 and 90.00 seconds on day first,
seventh and fourteenth day, while in Hydro alcoholic concentrate of Aloe Vera (300mg/kg)
treated gathering was 90.435, 86.00 and 80.00 seconds on day first, seventh and fourteenth
day 14.
Conclusion: The impact of Hydro alcoholic concentrate of Aloe Vera (150mg/kg and
300mg/kg) with standard medication Fluoxetine (20mg/kg) showed good upper
consequences for mice (p< 0.0005). Better impacts were seen by utilizing this medication.
So, the current examination recommends the better impact of Hydro alcoholic concentrate
of Aloe Vera about the stimulant impact in correlation with Fluoxetine