Keywords : Lipoprotein (a)
A Comparative Study of Serum Lipids Levels and lipoprotein A in Women with Pregnancy Induced Hypertension (PIH) and Normotensive pregnant women
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 3, Pages 3665-3667
Introduction:Hypertensive disorders complicating pregnancy is the one of the most common medical problem of pregnancy. Worldwide, hypertensive disorders in pregnancy causes complication in about 10 -16% of pregnancies. High blood pressure in pregnant women is related with incidence of large placental infarct and decreased placental growth resulting in intra uterine fetal growth restriction and intrauterine death. Hypertension in pregnancy is diagnosed when blood pressure is 140/90 mm of hg or greater with proteinuria and edema after 20 week of gestation. Plasma lipid and lipoprotein (a) undergo both qualitative and quantitative changes during pregnancy. During the course of normal pregnancy, plasma triglycerides and cholesterol concentration rises by 200-400% and 25-50% respectively. An abnormal lipid profile is known to be strongly associated with atherosclerotic changes and has direct effect on endothelial dysfunction. In preeclampsia women, thromboxane rise more than in normotensive pregnant women. Increased lipid synthesis causes increase in PGI2:TXA2 ratio and plays a role in pathogenesis of pregnancy induced hypertension (PIH), hence the hyperlipidemia may be an important marker of toxemia of pregnancy.
Aim and Objectives:To asses and compare the serum levels of lipid and lipoprotein (a) in pregnant women with PIH and normotensive pregnant women.
Materials and Methods: A study conducted on total of 100 pregnant patients (50 cases and 50 controls) selected according to inclusion and exclusion criteria. 3ml of venous blood was drawn to estimate total lipid profileand Serum Lipoprotein (a) levels in each subject.The data was analyzed results were expressed as Mean and standard deviation of various parameters in different group. P value < 0.05 is considered as significant. ROC curve analysis was done to assess maximum sensitivity, specificity and diagnostic efficiency
Results:In our study the mean ±SD values of total cholesterol, triglycerides, LDL,VLDL, Serum Lipoprotein (a) are statistically significant higher in PIH cases whereas HDL levels are low in cases when compared to controls.
Conclusion:A high lipid profile levels is observed to be associate with preeclampsia thus, serum lipid concentration and serum Lipoprotein (a) levels may provide a useful marker for screening patients at risk for developing PIH.