Online ISSN: 2515-8260

Keywords : carbamates


Outcome of organophosphorus poisoning cases at a tertiary care hospital

Dr. Sharanappa G Pattanshetty, Dr. Manoj Chandra MC, Dr. Divya Chandra, Dr. Nagaraj M Bhat B

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11930-11934

The treatment of a patient of suspected OPC Poisoning is initiated even before his/her admission to casualty in terms of decontamination by washing the contact body surface, removal of clothes and at arrival to casualty with suspicion of OP poisoning, history, examination, and specific treatment with investigations are carried out concurrently to reduce morbidity and mortality associated with OP poisoning. Ethical clearance was taken from the institutional ethical committee. Written informed consent was taken from all subjects and their attenders. In our study, total 7% patients went for intermediate syndrome, in that 5% patients were in mild group, 2% patients in moderate group. Compounds which led to IMS are Malathion-3%, Dimethoate2%, Parathion-2%, Dichlorovas-1%.

Synthesis And Biological Activity Of New Acetylene Ethers Of Carbamates

A.D. Djuraev; M.R. Yakubkhodjaeva; M.E. Abdullaeva; M.A. Atakhodjaeva

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3566-3582

Research objective: to synthesize new carbamate derivatives - ɣ-bromopropargyl ethers of carbamate derivatives for their further application as initial compounds in the synthesis of simple and asymmetric diacetylene ethers of carbamate derivatives.
Materials and methods. Infrared spectra on UR-20 and UR-10 spectrometer (“Carl Zeiss”, Germany) were applied at 3600-500 cm-1, in the form of tablets pressed with KBr. For determination of purity of the obtained compounds, a thin layer chromatography was used. As an adsorbent we used a layer of AI2O3 of the II activity degree, and an iodine vapor as a developer.
Results and Discussion. Using the method of bromination of propargyl ethers of carbamate derivatives, ɣ -bromopropargyl ethers of carbamate derivatives were obtained, used in the synthesis of simple and asymmetric diacetylene ethers of carbamate derivatives. The optimal conditions for their synthesis were established in the process of studying the effect of various factors. Besides, antifungal and herbicide activity of the synthesized compounds was studied and analyzed. Compounds with high antifungal and herbicidal activity were determined.
Conclusion. Convenient methods were developed for obtaining new ɣ-bromopropargyl ethers of carbamate derivatives during the investigation. New simple diacetylene ethers of carbamate derivatives were synthesized by the reaction of interaction on the basis of propargyl ethers and ɣ-bromopropargyl ethers of carbamate derivatives. New asymmetric diacetylene ethers of carbamate derivatives were synthesized by carrying out the reaction of interaction based on propargyl ethers and ɣ-bromopropargyl ethers of various carbamate derivatives.