European Journal of Molecular & Clinical Medicine

One of the most common causes of dialysis is diabetic nephropathy (DN), which can be
prevented or delayed with early identification. When it comes to chronic kidney disease (CKD)
and type 2 diabetes, little is known about the renal function marker serum cystatin C (sCysC) and
its link to glomerular filtration rate. In this study, we tested the efficacy of sCysC as a marker of
early DN and CKD in patients from the southern Indian coastal region

Background: Tissue inhibitor of metalloproteinase-2 (TIMP-2) is a member of the
matrix metalloproteinase family, inducer of G1 cell cycle arrest, it is a marker of
cellular stress in the early phase of tubular cell injury caused by a wide variety of
insults
Aim and objectives: The aim of this work was to study if urinary TIMP-2 can be used
as one of early biomarkers of acute kidney injury after cardiac surgery.
Subjects and Methods: This was cross sectional study was conducted in collaboration
between the Internal Medicine, Cardiothorathic and Clinical pathology departments,
Faculty of Medicine, Zagazig University Hospitals. A total number of 50 patients
were included and classified into two main groups: Group I : included 25 patients
who undergone coronary artery bypass graft. Group II: included 25 patients who
undergone valve replacement surgery. The patients were reclassified after the
procedure into two groups: AKI group: defined on 24 h creatinine level elevation
either by 25% of the basal level or by 0.3 mg/dl above the basal level. No AKI group:
No rise of the serum creatinine level after 24 hours of the operation. The duration of
the study ranged from12- 18 months.