Keywords : recalcitrant
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 3, Pages 3771-3777
Background:Dermatophytosis is a common skin diseasein Egypt. It iscaused by
keratinophilic fungi. Tinea become chronic, recurrent and resistant to traditional
therapies. Isotretinoin is a good adjuvant to systemic antifungal in chronic
dermatophytosis due to its keratolytic effect.
Aim: This is a prospective study to assess the effectiveness of combined oral
itraconazole/isotretinoin therapyin the treatment of chronic and recalcitrant
Patients and Methods:A total of 30 patients with chronic and/or recalcitrant
dermatophytosis were included. Potassium hydroxide microscopy was performed.All
the patients received combined oral itraconazole/isotretinoin therapy;Itraconazole
200 mg twice daily with adjuvant isotretinoin20 mg dailyfor 6 weeks. The patients
were followed up to 6 monthsfor signs of recurrence.
Results:Mycological cure was observed in83.3% andcomplete cureoccurred in 70%
of the patients.
Conclusions: Combined oral itraconazole/isotretinoin therapycould be an effective
treatment in recalcitrant dermatophytosis.