Online ISSN: 2515-8260

Keywords : Speckle Tracking Echocardiography

Evaluation of Cardiac Muscle Function Using Speckle Tracking in Non-ST-Elevation Myocardial infarction Patients

Alaa El-sayed Salama,Mohamed Hossam El-deenMohamed El-Shaer, Hisham Samir Roshdy Saleh, Islam Abou Bakr Abd El Kader

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3874-3887

Background:Ischemic heart disease is the number one cause of mortality worldwide resulting in
7 million of the 53 million deaths in reported in 2010. Acute coronary syndrome is divided into
ST-elevation myocardial infarction (STEMI), Non ST-elevation myocardial infarction
(NSTEMI) and unstable angina. NSTEMI and unstable angina share similar pathophysiology
and have similar clinical presentation with the only difference is positive cardiac biomarkers
(cardiac Troponins and CK-MB) in the case of NSTEMI. Two dimensional (2D) speckle
tracking echocardiography is a relatively new imaging technique. Like tissue Doppler imaging
(TDI), it allows calculation of myocardial velocities and distortion parameters like strain and
strain rate (SR) giving important information for assessment of systolic and diastolic function,
particularly longitudinal strain, which both sensitive and specific in post myocardial. The main
advantage of speckle tracking analysis is its ability to assess several planes (circumferential,
radial and longitudinal) giving accurate data about LV dimensions and deformation with good
correlation to tagged cMR and sonomicrometry as reference methods.The accuracy and
sensitivity of detecting MI visually by detecting segmental wall motion abnormalities are
moderate and operator dependent but improve greatly by using speckle analysis.

Assessment of Myocardial Abnormalities associated with Sickle Cell Disease Using Speckle Tracking Echocardiography

Mohamed Abd-Elmonem Ismail, SoadAbd-ElsalamShedeed, Ahmed AbdElsamadElhewala

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3888-3899

Background:Sickle cell disease (SCD) is a major health problem that affects over 20 million
people worldwide with over a billion dollars spent annually in the United States (US) itself to
cover healthcare costs. Approximately 300,000 children are born annually with SCD at least
75% of them are in Africa. SCD affects about 1 in 500 African Americans and nearly 1 in 12
African Americans carry the autosomal recessive gene. It is estimated that there are almost
100,000 SCD patients in the United States. Speckle-tracking echocardiography (STE) is a new
noninvasive ultrasound imaging technique that allows for an objective and quantitative
evaluation of the global and regional function of atrial and ventricular chambers. Although in
almost all patients with SCD, coronary angiography reveals normal coronary arteries, yet
myocardial ischemia and infarction have been reported to occur in SCD. Some SCD patients
have marked abnormalities in exercise capacity and cardiac filling abnormalities