Online ISSN: 2515-8260

Keywords : Toll-like Receptor (TLR)

Evaluation of Toll-like Receptors in Children with Inflammatory Bowel Disease

Hosna Yousef Saleh Yousef, Hatem Mohammed Elsaid Hussein, Mohamed Abd-Elkader Abdallah Almalky, Ahmed Mohamed MoradAsaad

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3928-3937

Background:Inflammatory bowel disease is a chronic inflammation of gastro- intestinal tract
(GIT), it include two forms, Ulcerative Colitis (UC) and Crohn's disease. Including ulcerative
colitis (UC) and Crohn's disease (CD), are chronic inflammatory disorders of the
gastrointestinal tract that begin most commonly during adolescence and young adulthood. In
patients with IBD, host genetic, environmental, and microbial influences converge and result in
a dysregulated mucosal immune response against the commensal intestinal microbiota. Cellular
receptors in the innate immune system are fundamental and recognize pathogenic molecules to
trigger immune responses. Additionally, some toll-like receptor (TLR) polymorphisms/mutations
have been identified and directly linked to IBD. Genetic alterations of these receptors might
change the composition of microbiota in the gut. Therefore, receptors of the innate immune
system, such as TLRs, impact many aspects of IBD etiology, including immune responses,
genetics, and microbiota