Online ISSN: 2515-8260

Keywords : Drug Utilization

Evaluation of Drug Utilization in Cardiovascular Disease: A Prospective Analysis

Deepty Arora, Kirti Vishwakarma, Mukesh Sharma, Navpreet Kaur

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 3586-3591

Background: Cardiovascular disease (CVD) is the major reason of mortality among noncommunicable diseases (NCDs), constituting 26% in India. The present study was conducted to evaluate drug utilization in cardiovascular disease.
Material and methods: The prospective observational study was conducted for a period of 6 months to evaluate drug utilization in cardiovascular disease. The study included a total of 600 patients admitted to intensive coronary care unit. All the medical prescriptions were collected and the data was used to analyze the prescription pattern by prescribing indicators and individual drug use by DDD measure. The data was collected and analyzed for counts and percentages. The mean and standard deviation was computed for continuous variables.
Results: Of the total 600 records, males were 60% and females were 40%. Ischemic Heart Disease (31.66%) and Hypertension (30.25%) were the most common cardiovascular diseases in the study population. Clopidogrel and Isosorbide dinitrate were most commonly prescribed Cardiovascular Drugs. It was found that Clopidogrel (51.80%), atorvastatin (48.95%), Isosorbide dinitrate (50.76%), were highly used. DDD was highest of Enalapril maleate i.e. 4.43. The average drugs per prescription during hospitalization was 4.15. Percentage number of drugs Prescribed by generic names was 71.5%. Percentage of Drugs Prescribed From National Essential Drug List was 88%.
Conclusion: The present study concluded that the most commonly prescribed medications are Clopidogrel, Isosorbide Dinitrate. Percentage of drugs prescribed by Generic name should be improved. The percentage of drugs prescribed form national Essential Drugs List was satisfactory but still have to be improved.


Dr. Bharti N. Karelia Dr. Kiran G.Piparva Dr. Parulben A. Patel

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 79-87

Aim: To evaluate drug utilization pattern of antidiabetic drug in type-2 diabetic patients
attending at private diabetes clinic. So that, this information can be used in assessment of
quality of care provided as well as to facilitate the rational use of drugs in populations
Objective: To evaluate the current trends of prescribing patterns of antidiabetic drug in type
2 diabetic patients
Material and Methods: An observational prospective study undertaken at diabetes clinic from January 2015 to April 2016 after approval from institutional ethic committee. Total 600 patients of type 2 diabetes mellitus were enrolled. Data related to demographic details of the patient (age, gender and BMI, occupation, social status), past history, family history, personal history, all investigations, drug treatment and adverse drug reaction were recorded in suitable case record form. Follow up was carried out for all patients every 3rd, 6th, 9th and 12th month visit for glycaemic control. Data were entered into Microsoft excel 2010 and analysed by descriptive statistics (percentage, mean, standard deviation) and chi square test.
Results: Out of 600 patients, 58.67% were males and 41.33% were females. The mean age of the patients was 51.85 ± 4.24 years. Hypertension (31%) was most common co-morbid illness.Most common complaint was weakness (18.33%). Majority prescriptions had fixed dose combination (FDC) of two antidiabetic drugs (93.2%). Most commonly prescribed FDC was of sulfonylureas (Gliclazide) and Biguanide group (Metformin)in 552(92%). Average number of drugs per encounter was 3.02, 0.3 % drug was prescribed by generic name, 4.17% drug was antibiotic, 7.7% drug was injectable medicine, 14.27% drugs was prescribed from national list of essential medicine and 11.35% drugs were prescribed from WHO essential list of medicine. Fixed dose combinations were prescribed in 57.27% of patients. Glycaemic controlled was observed in 32.84 % patients.
Conclusion: Sulfonylurea and Biguanide combination most commonly used to treat type 2 DM and among them Gliclazide and Metformin combinations was most commonly prescribed.