European Journal of Molecular & Clinical Medicine

Background:The periorbital region plays an important role in overall facial appearance and is one
of the first areas to reveal signs of ageing. The eyes in particular are often used as an immediate
gauge of chronological age. Consequently, there are many different treatment modalities currently
available for use or undergoing clinical investigations. The main targets of the treatments are
improvement, if not elimination, of rhytids and replacement of lost volume or removal of excess
volume in what is known as the tear trough region. Other characteristics of ageing skin include
rough, leathery and uneven skin texture, changes in pigmentation and dryness.