Online ISSN: 2515-8260

Keywords : Human papillomavirus (HPV)

Role of intralesional antigen immunotherapy in the treatment of warts

Najat Saed,Aymen Marei, Ahmad Nofal,Hagar Bessar

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 4191-4201

Background:Warts are the most common clinical manifestation of human papillomavirus
(HPV) infection in the skin and mucous membranes, mostly found on the hands, feet, face, and
genitalia. These benign lesions have different clinical forms. There are over 200 types of this
virus and some of them have contributed in the pathophysiology of wart. Each of its types is
different in at least 10% of the sequences encoded by major capsid gene (L1). Although these
viruses have a tendency to infect some specific body parts, this disease may be manifested in
approximately all regions of the skin and mucosa. In some previous studies, it has been shown
that mumps-measles-rubella (MMR) vaccine results in regression of warts via
immunomodulation and induction of delayed (cellular) hypersensitivity reactions at the wart
tissue. This method can be used in larger populations because of vaccine availability and safety.
The varicella zoster (VZV) vaccine, which contains live attenuated virus derived from the OKA