Online ISSN: 2515-8260

Keywords : BMI


ASSOCIATION OF ABDOMINAL OBESITY WITH PEAK EXPIRATORY FLOW RATE IN ADULT INDIAN MALES

Anju Goel, Taruna, Manisha Gupta, Prateek Agrawal

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 1673-1679

Background: Obesity is linked to a wide range of respiratory diseases such as asthma, chronic obstructive pulmonary disease, obstructive sleep apnoea, pulmonary embolic disease and aspiration pneumonia.
Aims and Objective: To assess the correlation between Obesity markers (BMI and waist circumference) and PEFR in adult males.
Material and Methods: One hundred male subjects in the age group of 20-50 years were recruited, their obesity parameters BMI and WC were recorded by standard methods and Peak expiratory flow rates by Mini Wright’s Peak flow meter.
Results: Pearson’s correlation coefficient showed a significant negative correlation of BMI with PEFR (r = -0.3885) and Waist circumference with PEFR (r = -0.4010, p<0.05). Conclusion: Obesity produces significant deterioration in the PEFR.

Correlation between BMI and plasma homocysteine levels in pre and postmenopausal women

Dr. Muruga, Dr. Rangaswamy R, Dr. Anurag Yadav, Dr. Vinay KS

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1915-1919

Homocysteine occupies a branch point in methionine, cysteine and S-adenosylmethionine (SAM) metabolism. About half of the homocysteine formed is conserved by remethylation to methionine in the “methionine cycle”. The other half is irreversibly converted by cystathionine-β-synthase (CBS) and cystathionine 𝛾-lyase to cysteine. After getting the informed consents from the subjects, 2.5ml of fasting blood samples were collected for lipid profile in a plain vacutainer tube and 2.5 ml of blood sample were collected in EDTA tubes for homocysteine estimation. This however, was done after the 7th day of the last menstrual period for premenopausal group. Samples were centrifuged at 3000 rpm to separate serum and plasma for the analysis of lipid profile and homocysteine estimation. The positive correlation between BMI and homocysteine which clearly indicates the increase in BMI results in increase in plasma homocysteine levels with Pearson correlation co-efficient of 0.232 and p value of 0.11.

A Comparison of the Effectiveness of Bone Marrow Aspiration (BMA), Bone Marrow Imprint (BMI) and Bone Marrow Biopsy (BMB) in Patients Suffering from Acute Leukaemia at Tertiary Care Center

Neeraj Verma, Yogesh Kumar Gupta, Madhuri Agarwal, Manish Kumar Singhal, Akansha Jain

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1355-1358

Background: Bone marrow examination is an important tool in diagnosing and
controlling hematological disorders. Bone marrow aspiration and trephine biopsy are
compatible. Thus; compiled the current study to evaluate and compare the effectiveness
of bone marrow aspiration, imprint and biopsy in patients with acute leukemia.
Materials& Methods: The present study was conducted in 50 clinically suspected
patients of leukemia who attended inpatient and outpatient department of medicine,
department of general pathology at SMS Medical College and Hospital, Jaipur,
Rajasthan, India over a period of one year. All Patients with leukemia who underwent
both bone marrow aspiration and bone marrow trephine biopsy examination were
included in the present study. We analyzed all the results by SPSS software. One way
ANOVA was used for assessment of level of significance. P- value of less than 0.05 was
taken as significant.
Results: The age of the patients ranged from 6 months to 70 years with male to female
ratio of 1.5:1. In three cases, dry tap was observed, which was further diagnosed with
BMI and BMBx. Diluted marrow was observed in two cases which was further
diagnosed with BMI and BMBx. Findings of BMI and BMBx were in concordance with
each other in 100 percent of the cases.
Conclusion: Bone marrow aspiration, imprint and biopsy are complementary to each
other with aspiration smears being primarily used for cytological diagnosis and biopsy
sections mainly useful to identify histological features like architectural pattern and
fibrosis.

To evaluate the Pre-hypertension among MBBS students and its associated factors

Dr. Sameer Srivastava,Dr.AnupamTyagi, Dr.Nandini Srivastava, Dr.Shyam Sunder Keshari

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1639-1647

Aim: To evaluate the Pre-hypertension among MBBS students and its associated factors.
Methods: 200 students of MBBS were included in this study. Out of these 200 participants,
60% were males and 40% were females. The mean age of the students was 22.55±7.66. As
per JNC 7 guidelines BP was measured, with a mercury sphygmomanometer.
Anthropometric measurements and basic laboratory parameters for blood glucose and lipid
profile estimation were measured in the study.

ASSESSING THE CORRELATION BETWEEN THYROID PROFILE AND CLINICAL DIAGNOSIS IN SUBJECTS WITH MULTINODULAR GOITER

Dr Md Rashid AhsanLodhi, Dr AsifAyaz, Dr SayantaannSaha, Dr. C. R. Mallikarjuna .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 3105-3108

Background: In endocrinology, the most commonly prevalent and undiagnosed condition encountered is thyroid dysfunction having a high burden on the healthcare sector in India. In addition, Iodine is an essential micronutrient for mental and physical growth in humans, its deficiency remains highly prevalent globally. Thyroid enlargement is commonly associated with thyroid deficiency clinically with decreased iron and selenium levels, and an increase in smoking, natural goitrogen, and TSH levels. Goiter representing enlargement of the entire thyroid gland is seen associated with raised levels of TSH, hyperthyroidism, or hypothyroidism.
Aim: The present clinical study was conducted to assess the association of thyroid hormone levels and goiter by assessing the thyroid profile in subjects with goiter.
Methods:The present cross-sectional study included 200 subjects comprising of 100 subjects with goiter and 100 normal healthy subjects in the age range of 18-35 years. For all the included subjects, thyroid hormone profile and thyroid function tests were assessed.
Results:The study results showed a significant difference between healthy subjects and subjects with goiter in hyperthyroid and hypothyroid subjects. The prevalence of goiter was largely influenced by lower and higher concentrations of TSH.
Conclusion:The present study concludes that the prevalence of goiter largely depends on abnormal and normal levels of Thyroid Stimulating Hormone (TSH) depicting hormonal dysfunction. TSH levels, thyroid nodules, and female gender were found to be the possible predictor for goiter, whereas, thyroid volume, TSH levels, and female gender were found to be predictors for thyroid nodules. Assessment of epidemiological profile is needed to obtain the definitive conclusion.

Retrospective Evaluation of Hypertrophy of Salpingopharyngeal Fold in OSA at a Tertiary Care Hospital

Jitendra Pratap Singh Chauhan, Raveendra Singh Rajpoot, Ajai Kumar, Somendra Pal Singh, Sunil Kumar Singh Bhadouria

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5769-5774

Introduction: The most common cause of sleep disordered breathing is reported to be
the obstructive sleep apnoea. It could possibly lead to serious physiological, social and
few neurocognitive disorders. Since the reported prevalence rate is higher, OSA has
often been misdiagnosed and unnoticed.
Materials and Methodology: This study was designed as a retrospective analysis of
patients reported with the polysomnographic confirmation of obstructive sleep apnoea.
Those patients included in this study had undergone Drug Induced Sleep Endoscopy
(DISE) using flexible video rhino-laryngoscope under BISTM monitoring which is
reported to be a valid bi-spectral index monitor in measuring the depth of sedation.
Drugs like dexmedetomidine and midazolam was initially used in titrating doses in
order to maintain BISTM score in the range of 60–80. The DISE video data of 189
patients was assessed by two ENT surgeons individually. Each of them was instructed to
grade the hypertrophy of the salpingopharyngeal fold as Grade 0 having normal
anatomy, Grade 1 being hypertrophy causing partial obstruction and Grade 2 being
hypertrophy which is reportedly responsible for complete obstruction of lateral
pharyngeal wall. Data of 160 patients of the 189 had 100% agreement between the two
expert surgeons while grading the hypertrophy. Thus, the data of 160 patients was
included in the study for further comparison and analyses. The patient’s data was
divided into two groups. Group 1 included 110 patients who had isolated palatal level
obstruction whereas group 2 constituted 50 patients affected with sleep apnoea due to
obstruction at multiple levels BMI of the patient was calculated. There was no
significant difference between the two groups for age (p<0.05), AHI (p <0.05) and BMI
(p<0.05) Shapiro Wilks test of Normality was applied to check for the distribution of the
data, non-normal distribution the data was subjected to non-parametric analyses.

Clinical profile of patients with type 2 diabetes mellitus at a tertiary care hospital

Dr. Nishchit KN, Dr. Akshatha K, Dr. Kalavathi GP

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 209-213

Macrovascular complications of diabetes mellitus include cardiovascular diseases, cerebrovascular
accidents and peripheral vascular disease. Macrovascular disease is a significant cause of mortality in
diabetic patients. Diabetic individuals have a multitude of risk factors for atherogenesis and the odds of
developing coronary artery disease and ischemic strokes are 2 to 4 times and 2 to 3 times more,
respectively, than non-diabetic individuals. This is a prospective observational comparative study in
which 60 patients with type 2 diabetes mellitus in the age group of 35-65 years were included and
results are compared with 60 Normal Individuals. The study design was approved by the Ethical
Committee of the institution. In NN group, 12(85.7%) patients were on OHA, 02(14.3%) patients on
insulin. In NH group, 19(82.6%) patients were on OHA, 04(17.4%) patient was on insulin. In HH
group, 16(69.6%) patients were on OHA, 7(30.4%) patients were on insulin. The distribution of BMI
among all the three groups was equal. P value was 0.215 which shows that the groups were similar to
each other in the distribution of BMI.

AN INSIGHT INTO THE CHILDHOOD OBESITY AND IMPORTANCE OF LIFESTYLE COUNSELING ON OBESITY STATUS

Dr. Tushar Ravindra Godbole,Dr. Rahul Gautam Koppikar

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 588-595

Background:Obese children also suffer from emotional, mental, and social trauma. Obese
children are seen to have depression and very low self-esteem. Also, such children are teased
by society and have high peer pressure. Additionally, obesity and overweight pose a high
burden on the health care system.
Aims:The present trial was carried out to document the efficacy of counseling about physical
activity, nutrition, and weight on obese children of low socioeconomic status.
Methods: The study was carried out on 48 children and was based on the questionnaire on
the lifestyle modification and counseling sessions with questions based on healthy habits and
physical exercise. Associated comorbidities such as asthma or diabetes were also asked along
with their treating paediatrician. The collected data were subjected to statistical evaluation
and the results were formulated.
Results: Counselling for nutrition, physical activity, and weight were provided to study
participants and the results showed that 80% (n=12) obese, 66.6% (n=6) overweight, and
58.3% (n=14) healthy subjects received counselling for nutrition. In male participants
61.53% (n=16), 69.23% (n=18), and 65.38% (n=17) respectively were counselled for
nutrition, physical activity, and weight. Similarly, in females 68.18% (n=15), 63.63% (n=14),
and 63.63% (n=14) respectively were counselled for nutrition, physical activity, and weight.
Regarding diabetics in the study (n=2), all the subjects were counselled for weight, nutrition,
as well as physical activity. In subjects with asthma, the counselling for nutrition, physical
activity, and weight was given to 63.6% (n=7), 54.5% (n=6), and 54.5% (n=6) respectively.
Conclusion:The present study concludes that overweight and obese children do not get more
counseling sessions compared to their healthy peers. There is a need for more interactions at
home and more reinforcement of counseling sessions in the school curriculum with special
emphasis on overweight and obese children regarding their nutrition, physical activity, and
weight.

A study on comparison of anthropometrical measurements in oraon and non-oraon boys

Dr. Kunj Bihari Patel, Dr. Meet Krishna, Dr. Avinash Thawait

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 37-45

A few studies based on published data have indicated patterns of anthropometric variation
along ethnic, geographic, latitude, longitude and altitude, nutrition and several confounding
variables.Many growth studies have been published for the tribal populations of Chhattisgarh.
However, no study, especially with regard to the growth status of the Oraons of Chhattisgarh
has been undertaken. Cases taken in this study were registered cases in government schools
of Jashpur district. 200 boys (100 Oraon and 100 Non Oraon) were included in the study
according to inclusion and exclusion criteria. Age range was 5-18 yrs. At most of the ages
BMI was less for OT boys than NO boys, except at the age periods of 17+ and 18+ where the
BMI of OT boys was more than NO boys. In the age period of 15+ the BMI of OT and NO
boys was found to be same. The difference was statistically significant at age periods of 7+,
8+ and 10+and highly significant in age period of 17+

A Hospital Based Observational Study to Evaluate the Effect of Prelabour Body Mass Index on the Mode of Delivery

Dr. Ramdas Garg, Dr. Avantica Agarwal

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 2679-2684

Background: Pre-pregnancy obesity is strongly associated with certain pregnancy
complications and perinatal conditions. Placental structure and function are important
for maternal and fetal health both during and after pregnancy. The aim of this study to
evaluate the effect of prelabour body mass index on the mode of delivery.
Materials and Methods: An hospital-based prospective study involving pregnant women
at term (33-37 weeks) admitted to gynaecology ward in district hospital Dholpur,
Rajasthan, India during one-year period. A total of 120 cases in the age group of 18-40
years included in the study. Patients were classified into 3 categories based on their first
trimester BMI. Category I included normal women (BMI 20- 24.9 kg/m2), Category II
included overweight women (BMI 25-29.9 kg/m2) and detailed history and clinical
examination including general physical, obstetrical and systemic examinations.
Category III included obese women (BMI >30 kg/m2). Data were analysed statistically
by Chi-square test of the dependence of variables and a p-value of less than 0.05 was
considered as statistically significant.
Results: Under anthropometric parameters, the differences in mean age, mean weight,
mean height and mean BMI among the three categories women were statistically
significant (p<0.001**), In this study, it was observed that overweight and obese women
were slightly older and short in stature when compared with women with normal BMI.
There was increased incidence of antepartum complications in Category III women as
compared to Category II and Category I women. The difference in the onset of labour
as well as mode of delivery among the three categories was statistically significant
(p<0.05*).
Conclusion: As obesity is a modifiable risk factor all attempts should be made to
maintain a normal BMI in women of childbearing age. Pre–pregnancy counselling,
health programme and appropriate multidisciplinary management should be done.

PREVALENCE OF PREHYPERTENSION AMONGST THE MEDICAL STUDENTS IN TELANGANA

Dr. Anand Ranjan Dr. Pradeep Shinde

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1772-1776

Aims: The main aims were to assess the incidence of prehypertension amongst the medical students in our institution with its correlation with increasing Body Mass Index (BMI) & to see if there was any gender variation.
Materials & Methods: A total of 500 medical students consented to participate in this study, their BP reading were recorded after a demographic questionnaire to assess their socioeconomic status & BMI.
Results: 277 students [55.4%) were prehypertensive out of which 145(29%) students had a high SBP & 132(26.4%) had high DBF. Amongst the 227 students, 33.2% had both high SBP & DBF out of which 64.1% were boys & 35.9% were girls. In the entire study population, out of the 500 students, 25% of the boys & 40% of the girls were overweight.
Conclusions: In our centre we had more than 50% of the study group in the prehypertensive range with a higher incidence amongst boys & about 40% of the girls were overweight these figures are alarming & hence a follow-up study is required for further analysis.

Development of Smart Health Monitoring System

D.S. Dayana; G. Kalpana; D. Godwin Immanuel

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 866-874

In the last few eras the humanity has witnessed an increase in visiting and downloading of
fitness applications. The theme of this project is to provide every possible tool which can be
helpful for Ones fitness journey. This app is used to track the fitness level of a person. It
shows user the holistic view of their health so that they never lose the track of their fitness.
This app is having certain options through which user can keep check on their fitness. It
can be used to track user’s progress by keeping check on their weight and their Calorie
Intake. This app will let user calculate BMI, BMR, calorie requirement and accordingly
provide meal plan and workout plan. There are researches and studies are going on
every day on various aspects of fitness, healthy living and diet. This app is also having a
discussion forum where people can post about various researches and their personal
health issues which can be resolved in the further posts.

Evaluation of the relationship between obesity and severity of periodontal diseases in rural population: A Study Protocol

Ms. Gauri , Bendre; Dr. Priyanka Jaiswal; Dr. Diksha Agrawal

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2034-2037

Abstract: Background- Excessive accumulation of fat results into obesity. Obesity further
have an adverse effect on health as it has been seen to be associated with diabetes mellitus,
hypertension, heart disease like coronary artery disease, cerebrovascular disease such as
hemorrhagic and ischemic stroke, metabolic syndrome like insulin resistance, some
cancers such as cancer of esophagus, thyroid, kidney, uterus, colon and breast, and
psychosocial problems. Also, obesity is considered to be a risk factor for periodontitis
which is an inflammation of supporting periodontal structures around the tooth which
results from the complex interaction between pathogenic bacteria and the host immune
response. However, the impact of obesity on different severity of periodontal disease is not
evaluated in rural population. Aim: To evaluate the relationship between obesity and the
severity of periodontal disease in Rural population. Methodology: A total 400 obese
subjects will be included in the study. Biometric parameters like age, weight, height, waist
and neck circumference, subcutaneous skin fold will be evaluated. Also periodontal
parameters like Plaque index (PI), Papillary bleeding index (PBI), Probing pocket depth
(PPD), Clinical attachment level (CAL) and Gingival recession (REC) will be evaluated
and co-relation between these parameters will be carried out. Results: A statistically
significant association will be observed between BMI and periodontitis of overweight and
obese study individuals having periodontitis. A positive co-relation will be observed
between biometric parameters and periodontal status of obese individual. Conclusion: A
significant association will be observed between BMI and periodontitis of overweight and
obese study individuals having periodontitis in rural population.

Effects Of Obesity On The Serum Levels Of Free And Total Prostate-Specific Antigen In A Sample Of Iraqi Men.

Dr Ziad Hammad Abd; Dr Ruya Abdulhadi M. Saeed; Omar Farhan Ammar (alrawi)

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 142-148

Objectives: the study aims to assess the relationship between obesity and prostatic markers (total prostatic specific antigen (tPSA), and free prostatic specific antigen (fPSA)). Methods: this study was conducted on 127 men aged ≥40 years at The Department of Urology at Al-Ramadi Teaching Hospital. Exclusion criteria were a history of previously diagnosed or treated prostate cancer, the use of prostacare or any drugs that affect the levels of PSA in the serum. Results: the age range of the participants of the study was between 40–80 year. The number of men with normal BMI was 26 (20.47%), 47 men were overweight (37%), 33 men were obese (25.98%), and finally, 21 men were severely obese (16.53%). The mean of parameters total and free prostate-specific antigen (tPSA, fPSA), in the study, were (mean ± SD) (1.683±0.563) ng/ml, (0.537±0.189) ng/ml, respectively. Conclusions: there are no significant relationships between BMI, tPSA, and fPSA, at P≤0.05 in a sample of Iraqi men.

Determination Of Trace Elements And Total Antioxidant Capacity İn Obese Iraqi Patients

Ibrahim Abdulkareem Sabri; Assistant professor Doctor Hakan ÇOLAK; Assistant professor Doctor Mustafa Taha Mohammed

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 2348-2358

Obesity is one of the principle preventable reasons for death. extra than forty % of Iraqis be afflicted by weight problems (obesity). is that it is excessive weight gain with excess body fat. This causes the patient to be exposed to several diseases. (weight problems) is measured in lots of ways, the most crucial of which is referred to as (BMI - body mass index), that's a tool for calculating weight in relation to frame height. someone is overweight if this indicator has a fee of 30 or more.
Methods: The study included healthy natural subjects as a comparison group (control) and they were (61 samples) Including (32) females and (29) males, and their ages ranged (3_15) years, and Patients Group (59 blood samples) were obtained they range in age (2_17) years, Included (35) males, (24) females.
Samples were collected from the patients reviewed at [Al Khayal Hospital].Level of antioxidants was assessed by estimation in the serum convergences of complete cancer prevention agents limit (TAC) by UV spectrophotometric strategy. also, Serum minor components (Zn, Cu and Fe) assessed by Atomic Absorption Spectroscopy (AAS .)
The Statistical Analysis System-SAS (2012) program was utilized to distinguish the impact of contrast factors in study boundaries. T-test was utilized to huge look at between implies. in this examination.
Result: Our study observed significantly elevated concentrations of (TAC)
(p < 0. 01)in the control than patient. Investigation of serum minor components (Zn, Cu and (Fe) found that the mean estimations of Zn, Fe, Cu, were (106.52 ± 0.76) and (70.44 ± 0.76), and (65.85 ± 1.97 ) μg/dl for the patient and (53.73 ± 2.11), (31.16 ± 0.87), and (91.12 ± 3.00) μg/dl for the controls, thusly. There was a significant contrast in minor components the patients and controls (p < 0.01).

Detection Some Biomarkkers In Sarcopenia Patients-Basra City

Abdullah Abbas Hamzah Al- Rubaye; Amna Nasser Habeeb

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 2417-2429

Background: Sarcopenia is a reduction in the rate, strength, and function of skeletal muscle mass that occurs mainly during aging, reduced physical activity, inflammation, and, or as a result of oxidative stress. C-terminal agrin fragment (CAF), procollagen type 3 N-terminal peptide (P3NT), and myostatin circulate biomarkers in elderly people associated with skeletal mass. Interleukin 6 (IL-6) is also a circulating inflammation marker that contributes to the release of hs-CRP and alpha1 antichymotrypsin (AACT).
The objective of Research: To define the differences between certain biomarkers in the sarcopenic subject, the study compared the findings with those of the non-sarcopenic subject that may support awareness of the sarcopenia principles.
Materials and Methods: The study was conducted on 170 participants living in Basra city. The weight (kilogram)/height (meter) 2 equation was used in the BMI calculation. Total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, and calcium were estimated by a fully automated biochemistry analyzer using enzymatic methods. VLDL-cholesterol was tallied by using the Fridwald equation. Vitamin D, IL-6, myostatin, CAF, P3NT, AACT, and hs-CRP were measured by a fully automated ELISA analyzer.
Results: current study parameters included (BMI, total cholesterol, triglyceride, VLDL-cholesterol, LDL-cholesterol, IL-6, myostatin, CAF, P3NT, AACT, and hs-CRP) ) in the sarcopenic subject showed more than the control subject with significantly higher changes (P<0.01)., whereas the parameters included (HDL-cholesterol, calcium, and vitamin D) were demonstrated in sarcopenia group less than 
a control group with significantly higher changes (P<0.01). BMI had a direct correlation with total cholesterol, triglyceride, LDL- cholesterol, VLDL-cholesterol, IL-6, myostatin, CAF, P3NT, AACT, and hs-CRP, with highly significant (P < 0.01). BMI had an inverse correlation with HDL-cholesterol, calcium, and vitamin D, with highly statistic changes (P <0.01).
Conclusions: A findings of the study revealed that obesity serves as a health risk for sarcopenia in elderly adults. High blood levels of total cholesterol, triglyceride, VLDL-cholesterol, LDL-cholesterol, myostatin, CAF, P3NT, IL-6 AACT, and hs-CRP in blood circulation raise the risk for sarcopenia in the elderly. Decrease concentrations of vitamin D, calcium, and HDL-cholesterol increase the opportunity for the elderly to have sarcopenia.

Risk Factors For The Progression Of Non-Alcoholic Fatty Liver Disease And The State Of Intestinal Microflora In Overweight And Obese Patients

Botir T. Daminov; Umida Sh. Usmanova; Bahromkhon A. Alavi; Gozal N. Sobirova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3535-3548

Recently, the growth of non-alcoholic fatty liver disease has been actively discussed in domestic and foreign literature. In Uzbekistan, the incidence of non-alcoholic fatty liver disease increased from 27.0% in 2007 to 37.1% in 2014 and ranked first among liver diseases.

SERUM LEPTIN LEVELS, BODY MASS INDEX AND ITS CORRELATION WITH MATERNOFETAL OUTCOME IN GESTATIONAL DIABETES MELLITUS

HARD TILVA; SUREKHA TAYADE

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2040-2048

BACKGROUND – Insulin resistance and profound changes in body weight are common features of pregnancy. Obesity in pregnant women and glucose intolerance due to insulin resistance, ultimately leading to Gestational Diabetes Mellitus (GDM), both can add to poor maternofetal outcome such as, macrosomia, prematurity, shoulder dystocia, preeclampsia, and even increased chances of fetal demise. Leptin is a novel potential regulator of insulin resistance. Measuring serum leptin levels in pregnant women with different BMI categories may potentially help in early detection of GDM, and predicting poor maternofetal outcome at early stages of pregnancy.
OBJECTIVES
1. To study serum leptin levels in women with GDM
2. To study the body mass index in women with GDM and classify study subjects according to BMI
3. To study the serum leptin levels in women with GDM belonging to various BMI categories and evaluate its association.
4. To correlate serum leptin and BMI with materno-fetal outcome in women with GDM
METHODOLOGY – This prospective hospital based study will be conducted in department of obstetrics and gynecology, at Acharya Vinoba Bhave Rural Hospital (AVBRH). 96 pregnant women seeking care at outpatient unit and/or in patient unit of Obstetrics & Gynaecology, in the AVBRH hospital, Sawangi, Meghe, in first trimester, will be included in the study. Screening for GDM in twice, first as soon as possible after diagnosis of pregnancy (first trimester) and second between 24-28 weeks, fasting Serum Leptin will be measured at 28 -32 weeks of gestation.
EXPECTED RESULT - It is expected that levels of Sr. Leptin will be higher in the women with GDM and will be abnormal in various BMI categories with a proportionate rise with increasing BMI.

“EVALUATION OF HOMOCYSTEINE LEVELS AND ITS CORRELATION WITH CLINICAL, METABOLIC AND HORMONAL PROFILE OF WOMEN WITH PCOS”

PRIYANJALI SINHA; NEEMA ACHARYA; PRIYANKA SINGH

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2104-2112

Background: PCOS is the most common endocrinological disorder affecting 6 -14% amongst reproductive age group. The pathophysiology of PCOS is complex and it is still not well understood. Many markers have been studied to correlate between homocysteine level and other clinical, metabolic and hormonal profile. Preliminary investigations indicate that in women with PCOS, serum biomarkers of cardiovascular disorders such as homocysteine are abnormal. Furthermore the interactions between homocysteine and PCOS, biochemical features such as obesity, insulin resistance and higher levels of androgen, have been researched and the potential determinant of this finding is still being explored.
Aim and Objectives: We aim to determine association between hyperhomocysteinemia and PCOS. The objectives of this study is to evaluate and compare clinical, metabolic and 
hormonal profile in women of PCOS with normal homocysteine level with that of increased homocysteine level.
Materials and Methods: This is a prospective observational study which will be performed in the department of obstetrics and gynaecology, AVBRH, DMIMS (Deemed to be University, Wardha), a tertiary care teaching hospital situated in the rural area of Wardha district in over 140 patients for period between 2020-22. This study will include PCOS patients based on Rotterdam diagnostic criteria and will exclude patients with known metabolic, cardiovascular and endocrine disorders. Metabolic and hormonal profile will be evaluated with BMI, Lipid profile, Insulin resistance, serum levels of LH, FSH, DHEA and Testosterone in all patients. Serum homocysteine levels will be measured using ELISA.
Expected Results: We expect that there will be significant difference in clinical, metabolic and hormonal profile of PCOS women having hyperhomocysteinemia than women having normal homocysteine level.

“COMPARATIVE EVALUATION OF NUTRITIONAL STATUS OF SHORTENED DENTAL ARCH PATIENTS WITH COMPLETELY DENTULOUS PATIENTS USING MINI NUTRITIONAL ASSESSMENT- SHORT FORM” - A CROSS- SECTIONAL STUDY.

Dr. Shanvi Agrawal; Dr. Seema Sathe Kambala

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2130-2139

BACKGROUND: There are various people having dental arches with edentulous areas which are unrestored and are present posterior to the natural remaining teeth. Such people are known to have a SDA or Shortened Dental Arch. Individuals having SDA may consume a limited diet, containing highly processed& soft foods which can aggravate the possibility of obesity.
OBJECTIVE: In this study, we will evaluate the difference in the nutritional status of the patient with SDA as compared to completely dentulous patients and propose a desired intervention for such patients.
METHODS: This research will be executed at “Department of Prosthodontics, Sharad Pawar Dental College, Sawangi (Meghe) DMIMS DU, Wardha”. Total 40 patients reporting to OPD with unrestored edentulous area posterior to natural teeth as well as completely dentulous patients will be included in this study .Nutritional assessment using “mini nutritional assessment- short form” is evaluated for every subject and compared.
RESULTS: It is expected that this study would provide an insight to the difference in the nutritional status of the patient with SDA as compared to completely dentulous patients and propose a desired intervention for such patients.
CONCLUSION- There are various people having dental arches with unrestored edentulous areas remaining distal to the remaining natural teeth. Such people are known to have a SDA or Shortened Dental Arch .Individuals having SDA may consume a limited diet, containing highly processed& soft foods which can aggravate the possibility of obesity. This study will aid in evaluating the difference in the nutritional status of the patient with SDA as compared to completely dentulous patients and propose a desired intervention for such patients.

Relationship Of Body Mass Indexwith Theperformance Of National Level Taekwondo Players

Sunil Singh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 3965-3969

The purpose of the present study was to analyse the relation of body mass index with the performance of Taekwondo players. The subjects selected for this study were national taekwondo players. The data for this study was collected during senior national taekwondo championship 2018. The data for body mass index was caluculated by using the weight and height data of the players. The data collected then was analysed using Pearson product moment correlation coefficient at 0.05 level of significance. The results of the study showed significantnegative relationship between body mass index and the performances of taekwondo players.

RELATION BETWEEN EARLY PREGNANCY BMI AND GESTATIONAL WEIGHT GAIN WITH NEONATAL BIRTH WEIGHT

N. S. Kshirsagar; Supriya patil; M. M. ladded; S.S. Vhalwal; Archna V. Rokade

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4130-4135

Study objective is to study the influence of early pregnancy BMI on neonatal birth weight. To Study the association between gestational weight gain and neonatal birth weight. An observational correlational study, consisting of 1031 pregnant women, with singleton uncomplicated pregnancy, booked at Krishna Institute of Medical Sciences, Karad before 12 weeks of pregnancy, conducted between June 2014 to December 2015. After getting written informed consent from the patient, patients included in the study. Those who developed any complication during the study were excluded. With rising BMI, weight gain in pregnancy is greatly increased. Maternal pregnancy BMI has a positive association with the birth weight of neonatal. Lower BMI is significantly linked to a relatively low weight gain lower birth weight.

PREVALENCE AND ASSOCIATED FACTORS OF MALNUTRITION AMONG MEDICAL STUDENTS IN INDIA

M. Kaja Lakshmy, E. Prabhakar Reddy

European Journal of Molecular & Clinical Medicine, 2018, Volume 5, Issue 1, Pages 193-199

Malnutrition includes both over nutrition and under nutrition. Country like Indiaharbours burden
of both types. College students are highly vulnerable to malnutrition as they seem tobe nonchalant
about their dietary habits, physical activity and general health due to academic burdenand lack of
time. With increasing importance given to physical appearance one group of students areinto diet,
consumption of dietary pills and bulimia. On the other hand another set of students areaddictedto
junk food andsedentarylife and end up in overnutrition. Our study aim is a) To estimate the
prevalence of malnutrition among medical studentsb) To assessthefactorsassociated with
malnutrition amongmedical students.Acrosssectionalstudy was done among undergraduate
medical students. Asemi-structuredquestionnairewasselfadministeredamong200studentsandalsoanthropometricexaminationwasconducted
andBMI
wascalculatedwiththe quetlet’s equation(weightinkgdivided by height in m2 ) The dietary habits
and intensity and frequency of physical activity werequestioned.Thedatawasentered in an Excel
sheet and theresults weretabulated.According to the WHO BMI scale , 13 students were
underweight , 113 were healthy ,55 were overweight and 19 were obese . Obese and Overweight
students were found to be morelethargicand had worsedietaryhabits than
thehealthystudents.Obesity and overweight is quite common among medical students .
Awarenessabout the ill effects of malnutrition has to be provided and medical students should be
encouraged totake care of their health so that they can adapt to a healthy lifestyle and also
practice the education ofhealthpromotion amongtheirpatients in future.