Online ISSN: 2515-8260

Keywords : X-ray diffraction

Design and Characterization of Fast Disintegrating Film for Phenobarbital

Bhambere Deepak S; Laddha Umesh D; Dashputre Neelam L; Kakad Smita K.

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 830-839

Epileptic seizures often cause transient impairment of consciousness, leaving the individual at risk of bodily harm. Therapy is symptomatic to which available drugs inhibit seizures. Phenobarbital exerts maximal antiseizure action at doses below those required for hypnosis. Phenobarbital is slowly absorbed from oral route, onset of action occurs within 30-60 mins, duration of action persist for 12-16 hours, 20-45% bound to plasma protein and only partly metabolized in the liver. Mouth dissolving films of phenobarbital can be used for emergency treatment of status epilepticus (SE) in all class of patients without need of trained persons. In the present work, an approach to develop and evaluate quick disintegrating films of Phenobarbital. Suitable film formers and plasticizers were selected based on optimization studies. Effect of superdisintegrants in formulation of mouth dissolving films at different concentrations has been investigated. Films were prepared by solvent casting method. The prepared films were evaluated for physicochemical parameters, in vitro disintegration & dissolution time, in vitro release rate study and stability study. The best formulation was found to be F3 showing 96.57 % drug release in 14 min, following first order kinetics. X-Ray diffraction studies show change in crystalline nature of drug in formulation.

Synthesis And Morphological Study Of Polyaniline

Samala Sai; Anil Kumar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 3848-3852

An experiment was done for the synthesis of the two types of polyaniline one is with the solvent and the other is without the solvent, after that we dry in the vacuum oven, which gives the two different types of morphologies. The polyaniline was prepared by the chemical oxidative polymerization method. For the characterisation of the polyaniline here we use scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy. Polyaniline is easily synthesised and available at a low cost. The prepared polyaniline has shown the amorphous nature of material.