Online ISSN: 2515-8260

Keywords : COVID

Neutrophilic lymphocyte ratio and lymphocyte monocyte ratio: prognostic significance in COVID 19

Dr Fayaz Ahmad Wani, Dr Aabhasha Parotra, Dr Aakriti Mahajan

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2809-2818

Aim: To evaluate neutrophilic lymphocyte ratio and lymphocyte monocyte ratio as prognostic markers in COVID 19.
Material and method: The present retrospective observational studyconducted in the department of Medicine, Government Medical College, Jammu for a period of one year. The study comprised of 100 Covid 19 RT PCR positive cases admitted patient in ICU as well as Ward, in covid care centre of Government Medical College, Jammu. Patients characteristics were obtained from the hospital covid care centre satisfying inclusion criteria from electronic medical records and demographic, clinical, laboratory data were extracted included age, sex clinical features, signs and symptoms, comorbidities, exposure history, oxygen support during hospitalization, duration of oxygen support during hospitalization,imaging features of the chest (CT scoring), laboratory findings (Hemogram, Total leucocyte count, differential counts, NLR and LMR. Complete blood count including NLR and LMR collected at day of admission and day 3 of admission and documented on a standardized proforma. Two outcomes were evaluated: “discharge” or “died.”
Results:In majority (53%) of patients, ventilation given was high flow followed by bipap (21%), ventimask (19%) and ventilator (5%). Ventilation given was room air in only 2 out of 100 patients (2%). In present study, only 10 out of 100 patients (10.00%) died.Discriminatory power of neutrophil lymphocyte ratio (AUC 0.865; 95% CI: 0.781 to 0.925) was excellent and discriminatory power of lymphocyte monocyte ratio (AUC 0.791; 95% CI: 0.698 to 0.867) was acceptable. Among both the parameters, neutrophil lymphocyte ratio was the best predictor of CTSI severity at cut off point of >3.57 with 86.50% chances of correctly predicting CTSI severity.
Conclusion: It can be concluded from the results that NLR may be a rapid, widely available, useful prognostic factor in the early screening of critical illness in patients with confirmed COVID-19.

Case series of Guillain Barre Syndrome variants associated with COVID- 19 infection

Vineet Sehgal, Priyanshu Bansal, Shaifali Arora

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 904-908

The novel corona virus has wreaked havoc in both developing and developed countries. The
respiratory effects of the virus were well reported early on but with each passing day, effects of
covid-19 on others systems came to light. In this report, we bring forward the series of Guillainbarre
syndrome (GBS) cases with the varying presentation in covid infected patients. In our cases,
GBS either occurred during ongoing covid symptoms or within the two weeks of resolution of covid
related pulmonary symptoms. Through this case series, we are reporting one case each of garden
variety, AMAN variety and Miller Fisher variant of GBS. We aim to supplement the already
existing limited data available on other systemic illnesses associated with covid-19 and to make
physicians aware of the potential neurological diagnosis in covid cases.

NeuromyelitisOptica like presentation following COVID vaccination

Shaifali Arora, Vineet Sehgal, Priyanshu Bansal

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 909-915

COVID vaccinations have been developed in the record time frame. But with such rapid
inventions, there comes a risk of potential side effects. Not many serious side effects linked to
vaccinations have been reported to date. Through our case report, we wish to present a 50-
year-old patient who suffered from a NeuromyelitisOptica-like presentation just 2 weeks after
the COVID vaccination. We aim to bring a potential side effect of the vaccine to physicians'
notice so that any patient with similar symptoms does not go undiagnosed. We do not want to
discourage people from taking vaccinations as these side effects are quite rare.

Role of vital parameters and biomarkers in predicting the outcome of patients in Covid ICU: A comparative study

SouravBansal, Arghadip Das,Nikhat Fatima Mansoori, Irshan Ali Mohammed, Vinodh Boopalraj

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1159-1168

Aim: The aim of the present study to compare the vital parameters and biomarkers in
predicting the outcome of patients in Covid ICU.
Methods: 200 patient were divided in to two groups, Group A of those who expired and
Group B of the survivors. The mean for each parameter was calculated and compared
among the two groups and based on which p value was calculated for each parameter
undertaken in clinical evaluation. Blood reports of investigations assessing the levels of
biomarkers like Procalcitonin (PCT), C- Reactive Protein (CRP), D-dimer, Ferritin,
Lactate dehydrogenase (LDH) and Interleukin-6 (IL-6) sent on first day and last day of
hospitalisation in covid ICU were collected for Group A (Expired) and Group B (Survived)
and master chart was prepared.
Results: The study population comprised of 200 confirmed Covid-19 cases, among which
those expired (Group A) were 103, and those who survived (Group B) were 97. The mean
age difference was statistically significant (p value = 0.003). The mean Heart Rate on day
of admission was statistically significant (p value = 0.005). The mean Heart Rate on last
day of hospitalisation difference was statistically significant (p value = 0.001). The
Median PCT levels along with along with its interquartile range in Group A (Expired)
versus Group B (Survivors) on day of admission the difference was statistically significant
(p value < 0.001). The Median Ferritin levels along with its interquartile range in Group A
(Expired) versus Group B (Survivors) on day of admission the difference was statistically
significant (p value < 0.0003). The Median Ferritin levels along with its interquartile range
in Group A (Expired) versus Group B (Survivors) on last day of hospitalisation the
difference was statistically significant (p value < 0.001).


Dr..Gomathi M; Dr.Jaikumar S

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5619-5626

The causative agent of coronavirus disease (COVID-19) has omnipresent worldwide spread, infecting more than two million people and causing over 150,000 deaths worldwide, resulting in devastating global health emergencies. Extreme acute respiratory syndrome 2 (sarkozydia) Early in its global expansion, the COVI-19 pandemic was further fuelled by insufficient access to laboratory research. Real-time RT-PCR Diagnostic Panel was the first test obtained from the US Food and Drug Administration on February 4, 2020, by the Centers for Disease Control and Prevention (CDC) 2019–Novel Coronavirus (2019–nCoV)1–3. This test was therefore introduced by a significant number of public health and clinical labs in the USA. Many manufacturers of commercial instruments then obtained EUAs for molecular SARS-CoV-2 identification. However, producers also assign reagents. Many of the clinical laboratories have therefore used several platforms to satisfy research criteria.


Dr.Srinivasan R Emeritus; Dr. Kumaravel S

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5636-5644

In recent months, the dissemination of the COVID-19 pandemic across the world was worrying. The use of face mask is important in order to slow down the rate of transmission of COVID-19 to humans, according to guidelines from the World Health Organisation (WHO). The use and manufacture of facial masks and other components (gloves, facial protectors, protection suits, safety shoes), made of polymeric materials like antiviral textiles, most of whom end in microplastic ponds, has been dramatically increased by this pandemic. The South America focus reflects an environmental issue, the use and mismanagement of this form of personal protective apparatus (PPE) 1,2. In addition, the use of plastics in a single use is being increased and the plastic recycling is being decreased as a result of the pandemic curfew, more waste from plastic is exacerbating on coasts and beaches. Researchers have recently developed nano-particles Ag and Cu for PPE antiviral polymeric textile technology to reduce contamination and spread of COVID-19. Antiviral polymer waste may, since they are a big emerging class of pollutants, have a long-term detrimental impact on marine ecosystems. This research also focuses on the broader use of plastics in beaches and the coast, which could raise the risks to aquatic organisms in the coming years, as well as the possibilities of the COVID-19 pandemic. The possible effects of the pandemic on waste management programmes and future study recommendations to develop adaptive coastal management policies are also discussed3,4.


Dr.Maunika M; Dr. Anand V

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5701-5706

When Coronavirus Disease 19 appeared in 2019, the public was renewedly worried about the spread of aeronautical and aerosolized viruses. Many contradictory dialogues on which types of personal safeguards defend dentists and patients better against viral exposure follow this issue. In this comprehensive analysis, we carry out a thorough and critical evaluation of face masks and face shields, some of the personal protections most widely prescribed against viral infection.
The roles and practises of most popular types of masks in odontology are described: operation masks, operative masks, and respiratory masks are filtered (also called N95s). Following this would be the crucial evaluation of masks used on the basis of an analysis of the recorded proven results in three main areas: the extent to which each type of mask is demonstrated to defend against airborne and aerosolized environments, the recorded possibility that masks are not acceptable and risk factors for both correct and incorrect use of masks1–3. Our examination finished with some realistic, evidentiary guidance for use in dentistry and dental clinics using this material.

Knowledge, Awareness And Practice Of Dental Practitioners Regarding COVID-19 Pandemic- A Cross-Sectional Study

Anmol Bagaria; Shivam Bhardwaj; Ritu Sharma; Vaishali .; Vipul Anand; Pratik Prakash Bumb

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 4625-4630

Background: The present study was conducted to assess knowledge, awareness and
practice of dental practitioners regarding COVID-19 pandemic.
Materials & Methods: 240 dental practitioners of both genders were provided with a
questionnaire regarding knowledge and practice regarding COVID-19 pandemic.
Results: 80% showed that SARS-CoV-2 is the cause of COVID- 19. 85% replied that 2-14
days is the incubation period of Covid- 19, 75% correctly replied that 6.8 % is the
incubation period for COVID- 19 and 82% replied that rRT-PCR is the laboratory test
available for detection of COVID- 19. 80% replied yes in order to provide treatment to
infected patients and 10% replied no. In response to question whether masks, head cap and
sanitizer protect against virus, 74% replied yes, 18% replied no and 8% replied don’t know.
The difference was significant (P< 0.05).
Conclusion: Dental practitioners had sufficient knowledge, awareness and practice
regarding COVID-19 pandemic.