Online ISSN: 2515-8260

Keywords : Neurobiology


AN EXTENSIVE REVIEW ON INTRICACIES OF AUTISM SPECTRUM DISORDER AND ASSOCIATED PHARMACOLOGICAL ACTIVITY OF CENTELLA ASIATICA

Anamika P. K; Dr. P. Muralidharan

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 662-679

A comprehensive study is undertakenon the functional development of brain in Autism Spectrum Disorder (ASD).Brain functionality trajectories are unique in autism spectrum disorder .Autism spectrum disorder (ASD) is a set of neuro developmental disorders characterized by a deficit in social behaviors and nonverbal interactions such as reduced eye contact, facial expression, and body gestures in the early childhood days till the age of three. It is not necessarily a single disorder, and it is broadly considered to be a multiple disorder resulting from genetic and non-genetic parameters and their interpretation. Hereditary study of ASD has acknowledged mutations that interfere with typical neurodevelopment in womb through childhood. These DNA complexities of genes have been involved in synaptogenesis and axon motility. Recent developments in neuroimaging studies have proved many vital perceptions in vivo into the pathological changes which occur in the patients’ brain with ASD. Amygdala plays a majorrole in the limbic system and the affective loop of the cortico-striato-thalamo-cortical circuit, in cognition and ASD has been proved invarious neuropathological and neuroimaging research findings. Besides the amygdala, the nucleus accumbent is also considered as the vital ingredient which is related with the social recognition response in ASD. Although educational and behavioral treatments have been the mainstay of the management of ASD, pharmacological and interventional treatments have also shown remarkable benefits in subjects with ASD. Also, there have been implications on few patients who experienced through one of the interventional treatments resulted improvement after deep brain stimulation. The key architecture of ASD development which could be the focus for intervention is still an untapped destination. Further work is needed to explore the horizons on the grey trajectories on ASD.

Dance and Music as a Therapy to Heal Physical and Psychological Pain: An Analytical Study of COVID-19 Patients during Quarantine

A. Cineka; J.Michael Raj

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 99-109

This paper delineates that involvement to dance and music is an active therapy that offers physical and psychological benefits for the people who affected with diseases. It is closely connected with human emotions which reduce the psychological pain and depression of people when they are getting involved with music and dance. Due to the outbreak of Coronavirus disease (COVID-19), patients are totally under stress and fear for life and livelihood. To overcome this perilous situation, involvement to dance and music is suggested to be an apt therapy that fights against the psychological and emotional effects through its unique power. Involvement to dance and music serves as a useful vehicle of hope and positivity to patients who are under quarantine. Hence, this paper aims to study the collaborative understanding of COVID-19 patients’ perspectives on the involvement to dance and music and how it relieves their psychological pain and gains their physical strength while diverting them from fear to during quarantine. There are 215 COVID-19 patients taken as subjects from Tamilnadu, India. There were ten questionnaires used to collect the data through Google forms. The data was analyzed through ANOVA calculation. The major finding of the study indicates that involvement to dance and music brings immeasurable healing to body and mind. Furthermore, this study recommends dance and music to be used as a therapy for COVID-19patients all over the world to keep them healthy and positive.