Online ISSN: 2515-8260

Keywords : Anemia


AFFECTIVE-RESPIRATORY PAROXYSMS IN CHILDREN: CLINICALNEUROLOGICAL ASPECTS

Ya.N. Madjidova; U.T. Babajanova; V.K. Abdullaeva; Sh.A. Shirmatov; Khalilova A.A

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1673-1679

Introduction. Affective-respiratory paroxysm (ARP) or breath-holding spells is a
common phenomenon that occurs in children from 6 months to 6 years. Up to 90% of
children experience ARP for the first time before the age of 18 months. The mechanism of
the condition is still unclear. Scientists have found that children with breath-holding spells
are much more likely to be diagnosed with iron-deficiency anemia and, perhaps, it
contributes to the development of pathology. 20-35% of children have a burdened family
history. Some families have a dominant type of inheritance.
Materials and Methods. The algorithm for examining children included: general
clinical, neurological and psychological examination of children, conducting laboratory
research, registration of an electroencephalogram, according to indications, conducting an
echocardiographic study. We examined 50 children with ARP aged 6 months to 6 years.
Research was carried out in the clinic of the Tashkent Pediatric Medical Institute. The
diagnosis of ARP was established based on the history provided by mothers and
observations of seizures. Paroxysms were defined as stopping the baby's breathing at
exhalation after deep inhalation during crying. Paroxysms were classified as cyanotic,
pale, and mixed.
Results. A detailed study of the passage of the ante-, intra- and postnatal periods
made it possible to determine the significance of various unfavorable factors such as
anemia (p <0.05), toxicosis (p <0.01), acute respiratory infections (p <0.1), stress, use of
obstetric aids (p <0.05) and birth trauma. (p <0.1). In addition to perinatal risk factors, 13
(28%) children were found to have a hereditary predisposition to ARP and 4 children (8%)
to epilepsy. In most cases, seizures began at 6–12 months of age (38%). According to our
observations, the main provoking factors of seizures were: anger, inability to get what you
want - 70%, pain - 18%, fear - 12%. At clinical and neurological examination in children,
ARP of neurotic nature (82%) prevailed over affectively provoked syncope (10%) and
"epileptic" ARP (8%). The seizures in most cases were characterized by a typical course,
medium duration and high frequency. When assessing psychoemotional and behavioral
characteristics, children with ARP were more sensitive, intense, persistent, active, less
distracted, and differed in mood variability compared to healthy children. According to the
indicators of the functional state of the autonomic nervous system in children of the main
group, the initial autonomic tone was characterized by sympathicotonia, normal autonomic
reactivity was recorded significantly less than in the control group (p <0.05). According to
the results of laboratory studies, anemia (88%) and hypocalcemia (82%) were significantly
more common in children with ARP. Analysis of electroencephalographic data revealed:
signs of age norm - in 14 (28%) children, signs of dysfunction of nonspecific midline
structures of the brain - in 6 (12%) children, general cerebral changes. - in 3 (6%)

IMPROVING THE TACTICS OF TREATING CHILDREN WITH SEVERE CEREBRAL PALSY

Zilola Mavlyanova; Gulnoza Burkhanova; Maftuna Ravshanova; Sardor Makhmudov; Sanzhar Kholboyev

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1623-1631

This article discusses severe forms of cerebral palsy in children of different ages
and the development of anemia in these children, and iron supplements are needed to treat
such children (III). The lack of data on this disease and the effect of ferric iron
preparations on the course and prognosis of infantile cerebral palsy served as the
relevance of the study.
The aim of the study. To evaluate the effectiveness of the use of ferric iron (Emfer)
preparations on the course and prognosis of infantile cerebral palsy.
Materials and research methods. To achieve this goal, the results of treatment of 67 sick
children with severe cerebral palsy were analyzed. Children age from 2 to 17 years old. All
patients were ranked by age groups in accordance with the age classification with the
GMFCS scale: up to 2 years old - 9 children (13.43%), 2-3 years old - 11 children (16.4%),
4-6 years old - 18 children (26.8%), 7-12 years old - 15 children (22.38%), 13-17 years old -
14 children (20.9%). The study group was divided into 3 subgroups of motor deficit
according to the GMFCS scale: level 3 - 16 children (23.88%), level 4 - 20 children
(29.85%), level 5 - 31 children (46.27%). All patients were divided into 2 groups - the main
group - 38 children (56.71%, age - 11.04 ± 6.3 years), for whom anemia was corrected
using the Emfer preparation based on ferric iron, and the comparison group - 29 children
(43.29%, age - 12.06 ± 5.1 years), who were treated without iron supplements.

Placental Morphometry In Post-Partum Mother With Anemia Running title : Placental Morphometry

Sri Rejeki; Septiana Arum Nur Aifa; Wulandari Meikawati; Sandeep Poddar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 110-115

Title of the Article: Placental Morphometry in Post-Partum Mother with Anemia
Context: Anemia in pregnancy affects the abnormality of the placenta, thereby causing a decrease in placental function. Babies born with an abnormal placenta carry a risk of developing arterial blockage, heart failure, hypertension, and cancer in the future.
Aims: Thus, the objective of this study was to determine the correlation between anemia in the third trimester of pregnancy and placental morphometry.
Method: A total of 44 placentas from pregnant women with anemia and no anemia were selected by consecutive sampling techniques. The placentas were measured directly in weight, diameter, thickness, surface area, length of the umbilical cord, and the shape of the placenta. The measurement results were tested with Pearson correlation and Rank Spearman, while the placenta shape was tested by Chi-square.
Result: As many as 75% of pregnant women experience anemia in the third trimester, by most of the placenta has normal weight and thickness, the diameter and length of the umbilical cord are all normal, and the size is mostly oval. The weight of placenta (p = 0.000), thickness of the placenta (p = 0.023), surface area of the placenta (p = 0.000) and diameter of the placenta (p = 0.000) have a correlation with anemia in pregnant women. Umbilical cord length (p = 0.872) means that it has no correlation with anemia in pregnant women. All of them have a direction of the correlation (r) negative.
Statistical analysis used: The test is carried out at a significance level (α) of 95%. Placenta shape (p = 1.00) meaning that it has no correlation with anemia in pregnant women, OR = 0.939 (95%, CI = 0.861-1.024).
Conclusion: The condition of anemia in third-trimester pregnant women has correlation with the weight, thickness, surface area, and diameter of the placenta but has no correlation with the length of the umbilical cord and the shape of the placenta.

ASSOCIATION BETWEEN HAEMOGLOBIN LEVEL AND SEVERITY OF PERIODONTITIS - AN INSTITUTION BASED STUDY

Subasree .Soundarajan; Sankari Malaippan; Priyalochana Gajendran

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1933-1942

The aim of the study was to investigate the association between haemoglobin level & severity of chronic periodontitis. This retrospective study was carried out by analysing the patient records from June 2019 to March 2020 at Saveetha Institute of Medical & Technical sciences (SIMATS).Two forty four patients were included in the study. Parameters assessed were a)Demographic details – Patient name, Patient identity number, Age & Sex; b)Periodontal parameters – Probing pocket depth (PDD), Loss of attachment (LOA), Bleeding on probing (BOP), Severity of Periodontitis (mild, moderate & severe);c) Blood parameters - Haemoglobin levels (g/dl). Data was analysed using SPSS version 23.0. Bivariate Pearson correlation of Haemoglobin with mean PPD, mean LOA & mean BOP score were calculated. Mean Hb was compared with severity of periodontitis using ANOVA. A total of 244 patients were included in the study. The mean age of the study sample was 40.42 (±11.38). Females constituted about 58.06%, whereas males constituted 41.4% of the study sample. Majority of the population had severe periodontitis (64.76%), followed by mild periodontitis (18.03%) & moderate periodontitis (17.21%). The mean haemoglobin level in severe periodontitis (13.35g/dl) is higher when compared to moderate and mild periodontitis (13.30g/dl & 13.18g/dl respectively). Mean PPD was 5.24 mm, mean LOA was 4.6 mm & mean BOP score was 0.98. Association between mean CAL and mean haemoglobin levels was positive and statistically significant with a p value of 0.012. Mean Hb level was not significantly different with varying severity of periodontitis