Online ISSN: 2515-8260

Keywords : Anemia


The Relationship between Iron Deficiency Anemia and Simple Febrile Convulsion in Children Aged 6 Months to 5 years

Mohammad Hadi Yarigarravesh; Shadi Izadbakhsh; Parastoo Amiri; Maryam Goudarzian; Mehdi Jalili Akbariyan; Kazem Hassanpour

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 1049-1057

This study aimed to evaluate the relationship between simple febrile convulsion and iron deficiency anemia in children. In this case-control study, 60 children aged 6 months to 5 years old with simple febrile convulsion hospitalized in the Pediatric Unit of Heshmatiyeh Hospital of Sabzevar. separately for case and control groups and the two groups were compared in terms of blood indexes and iron deficiency anemia. The significance level was considered Pvalue <0.05. The case and control groups were matched in terms of age and sex, and there was no significant difference between the two groups. The results showed the prevalence of iron deficiency anemia in the febrile convulsion group was somewhat lower than that of the control group. However, no significant difference was found between the two groups (p> 0.05). The results of this study showed that the risk of convulsion is not higher in cases with anemia. However, iron can be prescribed with caution for high-risk patients with a history of previous convulsion or a positive family history of this condition, if they suffer from iron deficiency anemia. Moreover, according to the results of previous studies and the present study, conducting extensive research simultaneously in several centers is recommended.

Assessment Of Erythropoietin Efficacy And Dosing In Hemodialysis Patients

Mostafa Fawzy Mohamed Selim; Essam Eldin Mahmoud Lotfy; Lamiaa Abd Elwahab Mohamed; Mahmoud Hosny Zahran

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2461-2469

Background: Anemia is a common complication in Chronic kidney disease (CKD) patients. It has a multi-factorial pathogenesis. Replenishing iron stores and giving ESAs are the main lines of treatment. There is a general agreement on the optimal route for iron supplementation in ESRD patients with the IV route but there is no such agreement on the optimal route for iron supplementation in pre-dialysis CKD patients. Erythropoiesis stimulating agents (ESAs) treatment represent an economic burden and has been linked to possible cardiovascular side effects. This study amid to assessing the efficacy of erythropoietin in treatment of anemia in CKD patients. Methods: A prospective cohort study was conducted in chronic kidney disease patients who had undergone hemodialysis in Met-Ghamr hospital of nephrology from February 2019 to July 2019. Included 50 patients on maintenance hemodialysis, we tested the efficacy through comparing the efficacy low fixed ESA dose (4000 IU IV once weekly) versus high fixed dose (4000 IU IV three times weekly). We divided group into two groups, group A and group B. group A were put on a fixed dose of 4000 IU Epoetin alfa once weekly and group B were put on a fixed dose of 4000 IU Epoetin alfa three times weekly. Results: After 6 months, We found a significant difference in hemoglobin response of the two subgroups in favor of subgroup IID (P = 0.004). Conclusion: That low dose ESAs is less effective in correction of anemia in dialysis patients than high dose ESAs.

EXPERIMENTAL CHRONIC TOXIC HEPATITIS AND HEMATOLOGICAL FEATURES IN THE DYNAMICS OF MOTHER’S AND THE OFFSPRING LACTATION

Bakhtiyor Burtkhanovich KHASANOV

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 1367-1373

The aim of the research was to study the occurrence of autoimmune processes in chronic
hepatitis and its effect on the hematological parameters of the mother and offspring in the
dynamics of lactation. Material and research methods - the work was carried out on white
outbred female rats, in which, after heliotrine intoxication before pregnancy, the presence of
antihepatic antibodies in female rats was carried out by a passive hem agglutination reaction
according to Boyden's method, as well as hematological parameters in the mother and
offspring in the dynamics of lactation by conventional methods. The presence of
antihepatocytic autoantibodies during lactation was established, mainly in blood serum, and in
small amounts in the milk of female rats, therefore, antihepatic antibodies of the mother in
toxic hepatitis are not a pathological agent for offspring during breastfeeding. In the body of
female rats and offspring, anemia develops, progressing until the second week of lactation,
that is, the transition of pups to a mixed diet, therefore, it is more expedient to carry out
therapeutic measures before this period.

Impact Of Chronic Heart Failure On Comorbidities In Hot Climates On The Quality Of Life And Clinical Condition Of Patients

Tosheva Kh.; Xalilova F.; Gadaev A; Erkinova N.; Djuraeva N.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 1080-1089

It is well known that one of the leading causes of death among the population is cardiovascular disease, and they are often complicated by CHF.
In European countries, the prevalence of CHF is 2.1%, with 90% of women over the age of 70 and 75% of men. In the United States, these numbers range from 1–1.5% and occur in 10% of the population over the age of 60.
According to a number of leading researchers around the world, the inclusion of concomitant diseases in CHF not only worsens its overall outcome, increases the number and duration of hospital treatments , but in some cases is also the leading cause of death. Some authors compare the dynamics of deaths observed in CHF with deaths due to oncological diseases.

Processed Food For Anemia Prevention From Biscuit Diversification Of Mango Seed Flour (Mangifera Indica L.) And Moringa Leaves Powder (Moringa Oleifera)

Rini Tri Hastuti; Youstiana Dwi Rusita; Nur Rachmat

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 4718-4724

Anemia is a health problem throughout the world, especially in developing countries, where an estimated 30% of the world's population suffers from anemia. The incidence of anemia in Central Java in 2013 reached 57.1%. Moringa leaves are rich in nutrients and are a source of beta carotene, vitamin C, iron, and potassium. The mango seed flour without going through the sulfurization stage contains 20.00% carbohydrates, 14.83% fat, and 4.84% protein. The manufacture of biscuits made of the main ingredients, namely Moringa leaf flour and mango seed flour, can be useful for preventing anemia.
Purpose: This study aims to produce alternative products and biscuit food innovations to prevent anemia, by knowing the results of the organoleptic test, hedonic test, and nutritional content.
Methods: This is descriptive research. The stages of making biscuits include mixing mango seed flour and Moringa leaves. Processed biscuits are then tested for organoleptic, hedonic test, and nutritional content. There are 30 respondents on the hedonic test in this study.
Result: Organoleptic test results found F1 = round shape, strong green color of moringa leaves, savory and bitter taste (typical of moringa), and distinctive aroma of moringa; F2 = round shape, green color of Moringa leaves, savory and distinctive taste of Moringa, and distinctive aroma of biscuits; F3 = round shape, light green color of moringa leaves, savory taste and distinctive aroma of biscuits. The hedonic test results, namely 30 responses, showed F1 as many as 27 respondents (90%) did not like, formula 2 as many as 23 respondents (76.7%) liked, and formula 3 as many as 22 respondents (73.3%) liked.The nutritional content test of the biscuits was selected at F2 with the result that the water content was 4.1%; ash content 1.38% (b / b); protein content 18.1%; fat content 30.2%, and iron content 37.2 mg
Conclusion: The formula that meets the requirements for the organoleptic test, hedonic test, and nutritional content with proximate analysis is formula 2.

Placental Morphometry In Post-Partum Mother With Anemia Running title : Placental Morphometry

Sri Rejeki; Septiana Arum Nur Aifa; Wulandari Meikawati; Sandeep Poddar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 110-115

Title of the Article: Placental Morphometry in Post-Partum Mother with Anemia
Context: Anemia in pregnancy affects the abnormality of the placenta, thereby causing a decrease in placental function. Babies born with an abnormal placenta carry a risk of developing arterial blockage, heart failure, hypertension, and cancer in the future.
Aims: Thus, the objective of this study was to determine the correlation between anemia in the third trimester of pregnancy and placental morphometry.
Method: A total of 44 placentas from pregnant women with anemia and no anemia were selected by consecutive sampling techniques. The placentas were measured directly in weight, diameter, thickness, surface area, length of the umbilical cord, and the shape of the placenta. The measurement results were tested with Pearson correlation and Rank Spearman, while the placenta shape was tested by Chi-square.
Result: As many as 75% of pregnant women experience anemia in the third trimester, by most of the placenta has normal weight and thickness, the diameter and length of the umbilical cord are all normal, and the size is mostly oval. The weight of placenta (p = 0.000), thickness of the placenta (p = 0.023), surface area of the placenta (p = 0.000) and diameter of the placenta (p = 0.000) have a correlation with anemia in pregnant women. Umbilical cord length (p = 0.872) means that it has no correlation with anemia in pregnant women. All of them have a direction of the correlation (r) negative.
Statistical analysis used: The test is carried out at a significance level (α) of 95%. Placenta shape (p = 1.00) meaning that it has no correlation with anemia in pregnant women, OR = 0.939 (95%, CI = 0.861-1.024).
Conclusion: The condition of anemia in third-trimester pregnant women has correlation with the weight, thickness, surface area, and diameter of the placenta but has no correlation with the length of the umbilical cord and the shape of the placenta.

Dates And Hemoglobin Levels: Literature Review

Dwi Ayu Rahmawati; Suryani As’ ad; A.Wardihan Sinrang; Ridni Husnah

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 2364-2370

Objective: The aim of this systematic review is to review studies on the effect of dates on increasing hemoglobin levels in anemia
Methods: the method used is an electronic database that has been published through the online libraries PubMed and Sciendirect. The keywords used for article searches are based on research questions. Result: a review of six health articles stated that dates are effective for increasing hemoglobin levels. Dosage, timing of administration, type of dates, food intake, a person's health condition should be of particular concern in giving date palm interventions. Not only increase hemoglobin levels, dates can also play a role in increasing ferritin, hematocrit, transferring saturation and serum iron levels in the majority of people.
Conclusion: dates can be used as an additional alternative to increase hemoglobin levels. However, disease or systemic syndrome in each person should be a concern because it can affect the effectiveness of dates in increasing hemoglobin levels.

Review of Pharmacological Aspects of Nothapodytes nimmoniana species

B. Durga; A. Julius; S. RaghavendraJayesh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1727-1732

Over 100 years of decay, major populace focus on traditional plants for treating massive disease due to the presence of active component. Biologically active compounds present in the medicinal plants have always been of huge curiosity to scientists for focusing on exploring plant products. Nothapodytes foetida (also known as Mappia foetida or Nothapodytes nimmoniana) is an average size tree belonging to family Icacinaceae. It is distributed in Southern India, North India, Srilanka, Myanmar and Thailand. It is an imperative medicinal plant, the foremost source of a potent alkaloid, namely camptothecin, of a wide spectrum of pharmacological activities like anti-cancer, anti-HIV, anti-malarial, antibacterial, anti-oxidant, anti-inflammatory, anti-fungal and also applied in the treatment of anemia. This review article compresses about the phytochemical constituent, pharmacological activity of bioactive component of N.nimmoniana species of root, stem, leaves and bark of the plants.

IMPROVING THE TACTICS OF TREATING CHILDREN WITH SEVERE CEREBRAL PALSY

Zilola Mavlyanova; Gulnoza Burkhanova; Maftuna Ravshanova; Sardor Makhmudov; Sanzhar Kholboyev

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1623-1631

This article discusses severe forms of cerebral palsy in children of different ages
and the development of anemia in these children, and iron supplements are needed to treat
such children (III). The lack of data on this disease and the effect of ferric iron
preparations on the course and prognosis of infantile cerebral palsy served as the
relevance of the study.
The aim of the study. To evaluate the effectiveness of the use of ferric iron (Emfer)
preparations on the course and prognosis of infantile cerebral palsy.
Materials and research methods. To achieve this goal, the results of treatment of 67 sick
children with severe cerebral palsy were analyzed. Children age from 2 to 17 years old. All
patients were ranked by age groups in accordance with the age classification with the
GMFCS scale: up to 2 years old - 9 children (13.43%), 2-3 years old - 11 children (16.4%),
4-6 years old - 18 children (26.8%), 7-12 years old - 15 children (22.38%), 13-17 years old -
14 children (20.9%). The study group was divided into 3 subgroups of motor deficit
according to the GMFCS scale: level 3 - 16 children (23.88%), level 4 - 20 children
(29.85%), level 5 - 31 children (46.27%). All patients were divided into 2 groups - the main
group - 38 children (56.71%, age - 11.04 ± 6.3 years), for whom anemia was corrected
using the Emfer preparation based on ferric iron, and the comparison group - 29 children
(43.29%, age - 12.06 ± 5.1 years), who were treated without iron supplements.

AFFECTIVE-RESPIRATORY PAROXYSMS IN CHILDREN: CLINICALNEUROLOGICAL ASPECTS

Ya.N. Madjidova; U.T. Babajanova; V.K. Abdullaeva; Sh.A. Shirmatov; Khalilova A.A

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1673-1679

Introduction. Affective-respiratory paroxysm (ARP) or breath-holding spells is a
common phenomenon that occurs in children from 6 months to 6 years. Up to 90% of
children experience ARP for the first time before the age of 18 months. The mechanism of
the condition is still unclear. Scientists have found that children with breath-holding spells
are much more likely to be diagnosed with iron-deficiency anemia and, perhaps, it
contributes to the development of pathology. 20-35% of children have a burdened family
history. Some families have a dominant type of inheritance.
Materials and Methods. The algorithm for examining children included: general
clinical, neurological and psychological examination of children, conducting laboratory
research, registration of an electroencephalogram, according to indications, conducting an
echocardiographic study. We examined 50 children with ARP aged 6 months to 6 years.
Research was carried out in the clinic of the Tashkent Pediatric Medical Institute. The
diagnosis of ARP was established based on the history provided by mothers and
observations of seizures. Paroxysms were defined as stopping the baby's breathing at
exhalation after deep inhalation during crying. Paroxysms were classified as cyanotic,
pale, and mixed.
Results. A detailed study of the passage of the ante-, intra- and postnatal periods
made it possible to determine the significance of various unfavorable factors such as
anemia (p <0.05), toxicosis (p <0.01), acute respiratory infections (p <0.1), stress, use of
obstetric aids (p <0.05) and birth trauma. (p <0.1). In addition to perinatal risk factors, 13
(28%) children were found to have a hereditary predisposition to ARP and 4 children (8%)
to epilepsy. In most cases, seizures began at 6–12 months of age (38%). According to our
observations, the main provoking factors of seizures were: anger, inability to get what you
want - 70%, pain - 18%, fear - 12%. At clinical and neurological examination in children,
ARP of neurotic nature (82%) prevailed over affectively provoked syncope (10%) and
"epileptic" ARP (8%). The seizures in most cases were characterized by a typical course,
medium duration and high frequency. When assessing psychoemotional and behavioral
characteristics, children with ARP were more sensitive, intense, persistent, active, less
distracted, and differed in mood variability compared to healthy children. According to the
indicators of the functional state of the autonomic nervous system in children of the main
group, the initial autonomic tone was characterized by sympathicotonia, normal autonomic
reactivity was recorded significantly less than in the control group (p <0.05). According to
the results of laboratory studies, anemia (88%) and hypocalcemia (82%) were significantly
more common in children with ARP. Analysis of electroencephalographic data revealed:
signs of age norm - in 14 (28%) children, signs of dysfunction of nonspecific midline
structures of the brain - in 6 (12%) children, general cerebral changes. - in 3 (6%)

PROCESSED FOOD FOR ANEMIA PREVENTION FROM BISCUIT DIVERSIFICATION OF MANGO SEED FLOUR (Mangifera indica L.) AND MORINGA LEAVES POWDER (Moringa oleifera)

Rini Tri Hastuti; YoustianaDwi Rusita; Nur Rachmat

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 5, Pages 1026-1032

Background:Anemia is a health problem throughout the world, especially in developing countries, where an estimated 30% of the world's population suffers from anemia. The incidence of anemia in Central Java in 2013 reached 57.1%. Moringa leaves are rich in nutrients and are a source of beta carotene, vitamin C, iron, and potassium. The mango seed flour without going through the sulfurization stage contains 20.00% carbohydrates, 14.83% fat, and 4.84% protein. The manufacture of biscuits made of the main ingredients, namely Moringa leaf flour and mango seed flour, can be useful for preventing anemia.
Purpose:This study aims to produce alternative products and biscuit food innovations to prevent anemia, by knowing the results of the organoleptic test, hedonic test, and nutritional content.
Methods:This is descriptive research. The stages of making biscuits include mixing mango seed flour and Moringa leaves. Processed biscuits are then tested for organoleptic, hedonic test, and nutritional content. There are 30 respondents on the hedonic test in this study.
Result: Organoleptic test results found F1 = round shape, strong green color of moringa leaves, savory and bitter taste (typical of moringa), and distinctive aroma of moringa; F2 = round shape, green color of Moringa leaves, savory and distinctive taste of Moringa, and distinctive aroma of biscuits; F3 = round shape, light green color of moringa leaves, savory taste and distinctive aroma of biscuits.The hedonic test results, namely 30 responses, showed F1 as many as 27 respondents (90%) did not like, formula 2 as many as 23 respondents (76.7%) liked, and formula 3 as many as 22 respondents (73.3%) liked.The nutritional content test of the biscuits was selected at F2 with the result that the water content was 4.1%; ash content 1.38% (b / b); protein content 18.1%; fat content 30.2%, and iron content 37.2 mg
Conclusion:The formula that meets the requirements for the organoleptic test, hedonic test, and nutritional content with proximate analysis is formula 2.

ASSOCIATION BETWEEN HAEMOGLOBIN LEVEL AND SEVERITY OF PERIODONTITIS - AN INSTITUTION BASED STUDY

Subasree .Soundarajan; Sankari Malaippan; Priyalochana Gajendran

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1933-1942

The aim of the study was to investigate the association between haemoglobin level & severity of chronic periodontitis. This retrospective study was carried out by analysing the patient records from June 2019 to March 2020 at Saveetha Institute of Medical & Technical sciences (SIMATS).Two forty four patients were included in the study. Parameters assessed were a)Demographic details – Patient name, Patient identity number, Age & Sex; b)Periodontal parameters – Probing pocket depth (PDD), Loss of attachment (LOA), Bleeding on probing (BOP), Severity of Periodontitis (mild, moderate & severe);c) Blood parameters - Haemoglobin levels (g/dl). Data was analysed using SPSS version 23.0. Bivariate Pearson correlation of Haemoglobin with mean PPD, mean LOA & mean BOP score were calculated. Mean Hb was compared with severity of periodontitis using ANOVA. A total of 244 patients were included in the study. The mean age of the study sample was 40.42 (±11.38). Females constituted about 58.06%, whereas males constituted 41.4% of the study sample. Majority of the population had severe periodontitis (64.76%), followed by mild periodontitis (18.03%) & moderate periodontitis (17.21%). The mean haemoglobin level in severe periodontitis (13.35g/dl) is higher when compared to moderate and mild periodontitis (13.30g/dl & 13.18g/dl respectively). Mean PPD was 5.24 mm, mean LOA was 4.6 mm & mean BOP score was 0.98. Association between mean CAL and mean haemoglobin levels was positive and statistically significant with a p value of 0.012. Mean Hb level was not significantly different with varying severity of periodontitis