Online ISSN: 2515-8260

Keywords : prostaglandin

Comparision of Progression of Labour and Fetomaternal Outcome Between Spontaneous and Induced Labour

Kesavachandra Gunakala, P.M.Rekha Rao, Mude Vennela, Haneesha M.S

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 6045-6051

Background:Induction of labour is artificial initiation of uterine contractions prior to
spontaneous onset leading to progressive dilatation and effacement of cervix. Induction
of labour process whether by administering foley bulb induction, stripping, oxytocin
(or) prostaglandin. Labour induction is indicated where the benefits of either the
mother or fetus outweighs the benefit of continuing pregnancy. Aims and Objective:
The aim of the study is to analyze the progression of labour and comparison of fetal and
maternal outcome between spontaneous and induced labour.
Materials and Methods: Present study is a prospective comparative study involving 200
participants divided into induction (study) and spontaneous (control) groups. Data was
collected on socio demographic factors, maternal complications and fetal outcome
.Those women who had spontaneous onset of labour and reached >4cm of cervix
dilatation were included in study group. Progress of labour is monitored by modified
WHO partographs. Women on induction reached >4cm dilatation of cervix were
included in control group. Informed consent taken from every participant in the study.
Results: In the study group, the mean duration of active phase in primigravida was
6.2hours and in multigravida was 3.7hours. In control group, the mean duration of
active phase in primigravida was 4.7hours and in multigravida was 2.5hours.In study
group, the duration of second stage in primigravida and multigravida was 46minutes
and 25minutes respectively whereas in control group, it is 40 minutes for primigravida
and 21 minutes for multigravida. Induced labour is associated with higher cesarean
section rates. Cephalopelvic disproportion was the most common indication for
cesarean section followed by failed induction.
Conclusion: The mean duration of active phase and second stage of labour is longer in
study group compared to control group. Neonatal outcome was similar in both groups
except for 1minute and 5-minute APGAR scores which were significantly higher in
spontaneous group. Augmentation of labour is frequently required in study group
rather than control group. Occurrence of maternal complications like PPH, fever,
vomiting and hyperstimulation of uterus showed no significant difference in both the

The Profile of Interleukin-6, PGE2, and Menstrual Pain Levels through the Counter-Pressure Regiosacralis Therapy

Sri Rejeki; Achmad Solichan, S.T., M.Kom; Machmudah .; Dwi Nur Rahmantika Puji Safitri; Sandeep Poddar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 122-128

Menstrual pain (dysmenorrhea) is a pain frequently felt by most women due to the progesterone hormone instability in blood. The pain is commonly felt since the first day of the menstrual period. The mostly used therapy for dysmenorrhea was the pain killing therapy which resulted to a number of bad side effects such as organ damage and hypertension. The non-pharmacological therapies, such as the counter-pressure region sacralis may become an effective and safe alternative to reduce pain. This research aims at describing the profile of interleukin-6, PGE2, and menstrual pain levels through counter-pressure region sacralis therapy. A quasiexperimental research method was conducted with research samples of 50 female teenagers who meet the inclusion criteria. Counter-pressure interventions were given three times when the pain occurred for 45-50 second per treatment. The pain level was measured before and after treatment through Numeric Rating Scale. The research result showed that respondents’ average age was 18.74 (± 3.148) years old, with the youngest age of 15 years old, and the oldest age of 35 years old; most respondents had their first menstrual period (menarche) at the age of 12.58 (± 1.23) years old; the average pain scale before intervention was 5.0 (± 1.54;max 3;min 9); the average pain scale after intervention was 2.53 (± 1.474;max 7;min 1); the average Interleukin-6 was 4.82 (± 5.66) pg/ml; and the average prostaglandin E-2 was 994.73 (± 221.82) pg/ml. This research concludes that counter-pressure region sacralis is effective to decrease menstrual pain.