Online ISSN: 2515-8260

Keywords : Hypertension


EFFECT OF ULTRASOUND CAVITATION VERSUS PHOSPHATIDYLCHOLINE IONTOPHORESIS ON CENTRAL OBESITY IN HYPERTENSIVE WOMEN

Mina Nashat Halim Farag; Ramez Yousry Fawzy Bakhoom; Ahmed Assem Abd El Rahim; Ahmed Aref Ahmed Hussein; Mahmoud Y Elzanaty

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 821-832

Background/aim: Central obesity (CO) confers a great threat on the cardio-metabolic health of
population. Central obesity is directly matched with increased visceral abdominal fat and it is also
matched with endothelial dysfunction, insulin resistance, hypercholesterolemia, and cancer.
Purpose of the study: This study was designed to compare between the effect of ultrasound
cavitation and phosphatidylcholine iontophoresis on central obesity in hypertensive women.
Material and methods:It is a randomized controlled trial performed on 40 hypertensive centrally
obese females divided into two equal groups. Group (A) consisted of 20 females received
ultrasound cavitation, Group (B) consisted of 20 females received phosphatidylcholine
iontophoresis. The primary outcome measures were waist circumference, visceral fat range,
systolic and diastolic blood pressure. Results: the results showed that there was statistically
significant improvement in central obesity and hypertension in Group A but there was statistically
significant improvement in central obesity but non-significant improvement in hypertension in
Group B. Improvement in Group A is more significant than in Group B regarding the percent of
decline in WC, VFR and DBP. Conclusion: there was improvement in central obesity and blood
pressure in women after applying ultrasound cavitation and phosphatidylcholine iontophoresis
with better results in ultrasound cavitation than phosphatidylcholine iontophoresis.

RELATIONSHIP BETWEEN FAMILY SUPPORT AND COMPLIANCE IN IMPLEMENTING DIET PROGRAMS FOR ELDERLY PEOPLE WITH HYPERTENSION

Nina Sumarni; Citra WindaniMambang Sari; Dadang Purnama

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 99-106

Family support plays an essential role in understanding lifestyle changes associated with chronic illness, changes needed to help sick members. Family support for patients with hypertension can improve health, and intensive support can reduce pain and help carry out a more disciplined diet program to be maximized. Low adherence to treatment makes it difficult to control his blood pressure. The purpose of this study was to determine the relationship between family support and commitment in implementing a diet program for elderly Hypertension in Muarasanding Village, Garut Regency.The type of correlative descriptive study that describes the relationship of family support with hypertension diet compliance. This study's population is hypertension sufferers in the Muara Sanding village located in the SiliwangiGarut Health Center working area. The sample is a total sampling of 51 respondents. The instrument used was a questionnaire. The validity test uses the product-moment correlation technique; the reliability test in GarutJayaraga Village is 20 elderly. Data analysis uses chi-square.The results of this study received as much support as 57% with a level of adherence to carrying out a diet of 55%, and categories that lacked family support 43% and who did not carry out dietary compliance 45%. Results of analysis Sig = 0.42 (a <0.05) means that HO is rejected and accepts H1. There is a relationship between family support and adherence in implementing a diet in the elderly with hypertension. The analysis also found a significant correlation value, with an equivalent odds ratio of 3,889, meaning families who support have the possibility of 3,889 times to comply with the hypertension diet program. Conclusion: There is a relationship between family support with adherence to implementing the diet.

PREVALENCE OF DIABETES MELLITUS AND HYPERTENSION AMONG PATIENTS UNDERGOING DENTAL IMPLANT TREATMENT - A HOSPITAL BASED ASSESSMENT

Vaishnavi Devi. B Priya lochana Gajendran Delphine Priscilla Antony. S

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3308-3324

The aim of this study is to retrospectively analyse the prevalence of diabetes mellitus and hypertension among patients undergoing  dental implant treatment in a dental hospital. All the patients reported in the month of June 2019 to March 2020 for implant placement was chosen for the study. Implant placement data of patients with diabetes mellitus and hypertension was collected from the dental hospital record system. Result data was tabulated in excel and statistical analysis was done using Statistical Software for the Social Sciences (SPSS) software. The non parametric Chi square test was done for statistical analysis. The prevalence of diabetes mellitus in patients undergoing implant placement is 4.2%, hypertension is 2.2% and coexisting diabetes mellitus and hypertension is 1.7% with a higher incidence in the male population and more common in the age group of 40 to 60 years. Knowledge about the prevalence of these conditions will be helpful to the clinician for proper management setup and precise diagnosis before implant therapy can prevent surgical and postoperative complications resulting in long term success of dental implants

The role of physical psychotherapy on quality of life in patients with hypertension with alexithymia

AtefehHaghighat .; Raheleh Haghighat .

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2154-2162

Studies have shown that it is easier for people, who are emotionally capable, to cope with life challenges and therefore they are healthier psychologically. Alexithymia exacerbates vulnerability to physical illness and predisposes to chronic illness. The aim of this study was to determine the role of physical psychotherapy on the quality of life of patients with hypertension with alexithymia. In this clinical trial with a pre-test post-test design, 60 patients with hypertension with alexithymia were purposefully selected from the patients referred to the health centers of Semnan and randomly assigned to the experimental and control groups. The intervention was performed during 1.5 months in the experimental group according to the steps designed in the protocol of physical psychotherapy. Data were collected using the Demographic Questionnaire, Toronto Alexithymia and Quality of Life Questionnaire (WHOQOL-BREF) and analyzed by descriptive, inferential and MANCOVA statistics. In multivariate analysis of covariance, there was a significant difference in the linear composition of alexithymia components and quality of life. Overall, physical psychotherapy has had a significant effect on improving alexithymia, blood pressure and quality of life. Therefore, according to the research findings, it can be said that physical psychotherapy has been effective in improving the quality of life and controlling blood pressure in patients with high blood pressure with alexithymia and performing this treatment in the above patients is recommended as a suitable complementary treatment.

THE ROLE OF PHYSICAL PSYCHOTHERAPY ON QUALITY OF LIFE IN PATIENTS WITH HYPERTENSION WITH ALEXITHYMIA.

Atefeh Haghighat; Raheleh Haghighat

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2345-2353

Studies have shown that it is easier for people, who are emotionally capable, to cope with life challenges and therefore they are healthier psychologically. Alexithymia exacerbates vulnerability to physical illness and predisposes to chronic illness. The aim of this study was to determine the role of physical psychotherapy on the quality of life of patients with hypertension with alexithymia. In this clinical trial with a pre-test post-test design, 60 patients with hypertension with alexithymia were purposefully selected from the patients referred to the health centers of Semnan and randomly assigned to the experimental and control groups. The intervention was performed during 1.5 months in the experimental group according to the steps designed in the protocol of physical psychotherapy. Data were collected using the Demographic Questionnaire, Toronto Alexithymia and Quality of Life Questionnaire (WHOQOL-BREF) and analyzed by descriptive, inferential and MANCOVA statistics. In multivariate analysis of covariance, there was a significant difference in the linear composition of alexithymia components and quality of life. Overall, physical psychotherapy has had a significant effect on improving alexithymia, blood pressure and quality of life. Therefore, according to the research findings, it can be said that physical psychotherapy hasbeen effective in improving the quality of life and controlling blood pressure in patients with high blood pressure with alexithymia and performing this treatment in the above patients is recommended as a suitable complementary treatment.

STUDY OF PREHYPERTENSION AND HYPERTENSION AMONG URBAN SCHOOL ADOLESCENTS AND THE DIETARY DETERMINANTS OF CHILDHOOD HYPERTENSION

Haris M. M; Soundarya M; Ravikumar G; Kamalakshi G Bhat; Basavaprabhu Achappa

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 1664-1674

Background: Adolescent health is important as theyare under a great amount of stress due to academic and peer pressures. This study aims to determine prevalence of pre-hypertension and hypertension in school adolescents and to identify diet as a risk factor in these children.Methodology - Cross sectional study was conducted among school adolescents(11- 14years). Anthropometric and blood pressure measurements were taken. 24 hour recall method was used to record the dietary intake and the total sodium, potassium, fat, fructose, caffeine, uric acid and fiber in the diet was estimated. Results - 500 adolescents were studied. Among the study population 6.4% were pre-hypertensive and 7.4% hypertensive with increased prevalence in girls. 9.8% were obese and 14.2% overweight. 14.3% obese and 11.3% overweight children had pre-hypertension. 30.6% obese and 9.9% overweight children had hypertension. Dietary analysis showed that normotensive children consumed lesser fructose (258mg), fat (12.8gm), sodium (89mg), and uric acid with more potassium (89mg), and fiber (10.2gm) per day as compared to the hypertensive children. Conclusions: There is high prevalence of asymptomatic hypertension among obese and over-weight school adolescents. Dietary differences were found between the hypertensive and normotensive adolescents with increased fat consumption showing statistical correlation with hypertension

EFFECT OF YOGIC PRACTICES ON LOW DENSITY LIPOPROTIEN (LDL) AND HIGH DENSITY LIPOPROTIEN (HDL) AMONG HYPERTENSIVE MIDDLE AGED WOMEN

M. Subha; S. Murugesan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 1090-1095
DOI: 10.31838/ejmcm.07.09.112

To access the influence of the yogic behaviours of Low density lipoprotein (LDL) and High Density Lipoprotein random group laboratory study was accessed which is the aim.  Using the Chennai random sampling group method 30 middle aged hypersensitive women were randomly selected in the age group of 35-45 years which were further divided into two groups of 15 participants, I and II. In hypertensive middle aged women than in control group low density lipoprotein (LDL) and high density lipoprotein (HDL) have been predicted for important differences in selected biochemical variables.  Before the launch of the training programme a preliminary test for two types of low density lipoprotein (LDL) and high density lipoprotein (HDL) was performed. Yogic practice for 60 minutes, 6 days a week for a total period of eight weeks were given to Group I subjects.  For group II (Control Group) there was an active resting place.  On the same selected dependent variables after the experimental period the two groups were retested again.  Between the experimental group and the control group to determine the important discrepancies the study of (ANCOVA) was used.  The significance test was set at a degree of confidence of 0.05.  Due to the Yogic behaviours among hypertensive middle aged people such as Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) the experimental group showed important differences on selected biochemical variables which was revealed by the study.

The Oxidative Effect Of Nlrp3 And Cyp2e1 In Development Of Renal Failure Associated With Hypertension And Diabetes Mellitus Diseases

Alyaa Abdulhadi Salih; Kareem Hamadx Kareem Hamad Ghali2

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 636-644

Renal Failure (RF) is devastating pathology with several causative factors, resulting in dialysis or kidney transplantation needed by end-stage renal disease (ESRD. The progression of RF is closely related to systemic oxidative stress, which causes various complications such as hypertension and diabetic mellitus . The current study was focusing on the oxidative effects of NLRP3 and CYP2E1 gene expression in the pathological development of renal failure disease with hypertension and diabetic mellitus as complications associated diseases. This study involved 100 patients diagnosed clinically and seriologicaly with renal failure 52 males and 48 females, their age from 17 to 80 years . Also the study comprise (18 males and 12 females) healthy volunteers as control group. RNA extracted from blood samples and converted to cDNA which subjected to real-time PCR for detection gene expression . The results detected that Hypertension and diabetic mellitus are the important risk factors that causes and advances renal failure disease . NLRP3 and CYP2E1 have significantly overexpression (1.60 folds and 5.37 folds ) respectively in RF patients compared with healthy group ( p <0.05). However, the expression of NLRP3 and CYP2E1 increase in diabetic mellitus (2.16 and 1.58 ) respectively than hypertension in RF patients with and control group (p<0.05). Diabetic mellitus generate free radical consequently causes ROS, hence elevated expression in oxidative NLRP3 and CYP2E1 genes in diabetic RF patients .

Effects of Psychological Distress on Hypertension among Liquefaction Refugees in Petobo Shelter

Herawanto .; Vidyana Aulia Rahma; Muh. Jusman Rau; Sendhy Krisnasari

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 89-96

The purpose of this research is to know the psychological disorder in the incidence of hypertension among liquefaction refugees in Petobo Shelter. A cross-sectional design was performed. The total number of patients who visit the health post at a Petobo shelter is 3,079 people taken in accidental sampling. The analysis uses the univariate and bivariate analyses at a degree of confidence of 95% (α = 0.05). The chi-square test results show that anxiety (ρ = 0,031), depression (ρ = 0,008), and stress (ρ = 0,000) are associated with the incidence of hypertension. It is expected that hypertension sufferers should do breathing exercises, perform physical activity and meditation relaxation to avoid anxiety, negative thoughts, also avoiding depression, stress and do interact with someone else so that the mind is not saturated and easy to forget the negative thoughts.

ERYTHROCYTE TRANSMEMBRANE FLUX AND MEMBRANE TRANSPORT ABNORMALITY IN PATHOGENESIS OF HYPERTENSION LEADING TO NEPHROLITHIASIS

RENUGADEVI KARTHIKEYAN; JULIUS AMALDAS; PRAKASH DHARMALINGAM

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1698-1705

The epidemiological relationship between nephrolithiasis and hypertension is well-known. Patients with hypertension are at increased risk for nephrolithiasis and those with nephrolithiasis are at risk for hypertension. An anomaly in RBC Oxalate transport and reduced activities of adenosine triphosphatases has been reported in patients with hypertension when compare to control subjects. This study presents an abnormal increase in transmembrane flux of oxalate in RBC of hypertensive subjects and it might be due to membrane degradation caused by oxalate-induced free radicals depleting erythrocyte thiol contents and impaired adenosine triphosphatases activity resulting in tissue injury and defective membrane transport. Thus relative risk of hypertension was significantly associated with increased oxalate flux rate and impaired adenosine triphosphatases activity in stone formers. This association is important when treating patients with nephrolithiasis since those with hypertension may require unique dietary and medical therapy.

Preparation And Characterization Of Immediate Releasefilm Coated Tablets Of Valsartan -Hydrochlorothiazide (160/12.5mg)

Rakesh Kumar Sharma; Vikas Bansal; Amit Mittal; Mamta Sharma

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2915-2948

Objective:The motive of the currentworkwas to Preparation and Characterization of Immediate Release film coated tablets Valsartan -Hydrochlorothiazide (160/12.5mg) to reduce the multiple dosing and to achieve more effective reduction of hypertension.
Background: The oral route is the very effective and favoured method for the introduction of medications to systemic circulation because of ease of diagnosis, patient compliance and flexibility.
Materials and Methods: Valsartan - Hydrochlorothiazide tablet tends to film coated to prevent the drug from degradation. Preliminary studies were performed out with the excipients and the drug and their physical & chemical compatibilities were checked and the drugs and they found compatible.The method of preparation was the wet granulation method.
Results:A maximum of nine formulation batches (f1-f9) have been prepared.Prepared formulations have also been tested for weight variance, friability, disintegration, analysis, in vitro drug release profile.The criteria tested are contained within the guidelines.The parameters tested were found within the limits. Among all formulations, the product of batch f9 has acceptable friability, assay and dissolution profile. It was further exposed to an advanced stability test at 40±20C/75±5 per cent RH.

Distribution Of Metabolic Syndrome Components In Patients Younger Than 50 Years Of Age Of Indian Population

Dr. Inder pal Singh; Dr. Kamaldeep kaur; Dr. Lovleen Bhatia; Dr. Ajay pal

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 4786-4793

Background: Prevalence of the metabolic syndrome (MetS) is associated with increased risk of cardiovascular disease and diabetes. Present study aimed to assess the frequency distribution of various components of metabolic syndrome in patients younger than 50 years of age.
Materials and method: The study group consisted of 100 patients less than 50 years of age admitted at Rajindra Hospital with acute coronary disease.
Results: Most common age group was 45-50 years in both males and females, with 66% patients belongs to this age group. 37 patients of ACS with MS, most common component in males was raised blood pressure (SBP and DBP), in females most common component was impaired fasting plasma glucose (FPG). Waist circumference was statistically significantly raised in patients of ACS with MetS as compared to patients of ACS without MetS. Systolic blood pressure (SBP) was statistically significantly raised in patients of ACS with MS as compared to patients of ACS without MS. Systolic blood pressure (SBP) was statistically significantly raised in patients of ACS with MetS as compared to patients of ACS without MetS. Fasting plasma glucose (FPG) Serum triglycerides(TGc) and Serum high density lipoproteins (LDL) was statistically significantly raised in patients of ACS
Conclusion: All the five components of metabolic syndrome i.e. waist circumference, systolic blood pressure, fasting plasma glucose, serum triglycerides, serum high density lipoproteins were significantly associated with patients of acute coronary syndrome with metabolic syndrome as compared to patients of acute coronary syndrome without metabolic syndrome.

BLOOD PRESSURE PROFILE IN SCHOOL CHILDREN IN RURAL AND URBAN AREA IN AND AROUND KARAD

D. B. Potdar; Prashnt P. Shah; Naredra P. Porval

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4168-4174

A cross sectional study among 1000 school going children of age group 6 – 16 years was conducted to study the relation of Blood Pressure with variables Like Body Mass Index, Socio Economic Status, Family History of Hypertension, Age and Sex at our tertiary care hospital Krishna Institute of Medical Sciences Deemed University, Karad. 1.The study group had 100 (10%) children of 13, 14, 15 and 16 years, 90 (9%) children of 6, 8, 9 and 12 years and 80 (8%) children of 7, 10 and 11 years. 12.Systolic hypertension was observed in 13.3% of overweight and 6.7% of obese children. Systolic prehypertension was observed in 11.7% of overweight and 13.3% of obese children. BMI was significantly associated with pre hypertension and hypertension (SBP) in children (p<0.001). Diastolic hypertension was observed in 16.7% of overweight and 6.7% of obese children. Diastolic prehypertension was observed in 18.3% of overweight and 20% of obese children. Only 1.7% and 0.9% of prehypertension and hypertensive children had normal BMI.

ORAL NIFEDIPINE VERSUS ORAL LABETALOL IN THE TREATMENT OF PREGNANCY INDUCED HYPERTENSION

R.P. Patange; Archna V. Rokadhe; Ghori R. Shinde; Sanjay N. Jadhav; Ashitosh Bahulekar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4136-4141

This study was undertaken to determine the effectiveness of two anti-hypertensive drugs: oral Nifedipine and oral Labetalol in cases of extreme preeclampsia in terms of their side effect profile, BP regulation, time taken to lower BP, and number of doses required. The objective of the study was to calculate the time required to reduce the blood pressure to the target level of 90 / 100 mmHg diastolic and less than 160mmHg systolic.In the labetalol group the mean SBP before treatment was 158mm of Hg which was reduced to 140 mm of Hg. The decline rate in the labetalol group was 11.77%. This study proved that labetalol reduces the BP more effectively than nifedipine and also has minimal side effects with less frequent dosing schedule as compared to nifedipine thus indicating that labetalol is better than nifedipine in lowering the BP in cases of preeclampsia.

AWARENESS, KNOWLEDGE AND PREVALENCE OF HYPERTENSION, SLEEP APNEA AND SLEEP - DISORDERED BREATHING DIFFICULTIES IN MALES AMONG CHENNAI POPULATION

Shruthi Manivannan; Karthik Ganesh Mohanraj; Murugan Thamaraiselvan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 810-821

Hypertension, sleep apnea and sleep disordered breathing are the important Global public health challenges the world is facing nowadays with the highest prevalence rate all over the world. Recently a large body of work has been going on in finding the association of sleep- disordered breathing, sleep Apnea and Hypertension in the Male population.The aim of this study is to determine the association of sleep- disordered breathing, sleep Apnea and Hypertension in the young, Adult and aged Male population.Standard survey questions based on sleep disordered breathing, sleep apnea and hypertension were designed and was uploaded in an online survey platform and circulated among the males. A total of 100 responses were collected and were statistically analysed. In this study we observed that there is an association of sleep disordered breathing, sleep apnea with hypertension (p<0.001, independent sample t-test).Since there were no previous studies to encounter this association in India. This study serves as an eye opener for the early diagnosis and treatment of sleep disordered breathing, sleep apnea and hypertension in the young, Adult and aged Male population. This study will be beneficial in the awareness of health care professionals to consider the evaluation of patients with hypertension, sleep apnea and sleep disordered breathing