Online ISSN: 2515-8260

Keywords : Testosterone


B. Shalini; R. Elangovan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 1103-1109
DOI: 10.31838/ejmcm.07.09.114

To determine the effectiveness of Body Mass Index (BMI) and Testosterone yoga therapy in adult women the random group experimental research was the main goal. Thirty adult women between the ages of 20 and 35 years were randomly chosen using the Chennai random sampling group method for the purpose of study and were split into two groups, I and II, of 15 subjects each. It was hypothesised that the physiological and hormonal variables chosen, such as the Body Mass Index (BMI) and testosterone, will vary substantially from the control group among adult people. Before the start of the training programme, a preliminary evaluation for two classes on Body Mass Index (BMI) and testosterone was carried out. Community I subjects earned 60 minutes of yoga practise, 6 days a week for a cumulative duration of eight weeks. Group II (Control Group) had an active resting place. After the experimental period, the two groups were retested on the same selected dependent variables again. The study of co-variance (ANCOVA) was used to determine the important discrepancies between the experimental group and the control group. The significance test was set at a degree of trust of 0.05. The research findings found that the Intervention Group showed substantial variations between adult women with PCOS compared to the Placebo Group attributable to yoga therapy on selected biochemical and hormonal factors such as Body Mass Index (BMI) and testosterone. The theory was agreed at a confidence level of 0.05. It is also concluded that yoga therapy is effective in preserving a stable body mass index (BMI) and testosterone amount for adult women with PCOS.

The Administration Effect Of Tryptophan On Testosterone And Estradiol Hormone Levels In White Male Rats

Angga Putri; Yenni Aryanetta; Eryati Darwin; Arni Amir; Chablullah Wibisono

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 142-147

Objective to assess the influence of administering the tryptophan in the white male rats Rattus novergicus's testosterone and estradiol hormone levels. This research is experimental with the design of the posttest only control group design. The samples used as many as 28 rats were divided into 4 treatment groups. Each group is given an intraperitoneal injection of tryptophan with a dose level of 40mg, 50mg and 60mg/kg of bady weight. While one group was separated and made as control group. The treatments are given for 14 days and measured hormone levels using RIA. Based on assessment results, it was observed that there was a decrease in the average levels of testosterone (13,78nmol/L) and also observed an increase in the average level of the estradiol (8,65pg/dl) in the male white rat Rattus norvegicus when compared to the control group. The doses of tryptophan administered in the treatment group 1 is 40mg obtained the average testosterone levels 12,95nmol/L and average estradiol level of 9,87pg/dl. The doses of tryptophan administered in the treatment group 2 is 50mg obtained an average testosterone level of 11.03nmol/L and average estradiol level of 10,17pg/dl. The administration of tryptophan caused a decrease in the average testosterone levels in the control group and an increase in the average levels of estradiol compared to the control group even though the increase and decrease in the mean was not significant. It is likely that intraperitoneal administration of tryptophan has inhibitory effect of estradiol on testosterone.



European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2104-2112

Background: PCOS is the most common endocrinological disorder affecting 6 -14% amongst reproductive age group. The pathophysiology of PCOS is complex and it is still not well understood. Many markers have been studied to correlate between homocysteine level and other clinical, metabolic and hormonal profile. Preliminary investigations indicate that in women with PCOS, serum biomarkers of cardiovascular disorders such as homocysteine are abnormal. Furthermore the interactions between homocysteine and PCOS, biochemical features such as obesity, insulin resistance and higher levels of androgen, have been researched and the potential determinant of this finding is still being explored.
Aim and Objectives: We aim to determine association between hyperhomocysteinemia and PCOS. The objectives of this study is to evaluate and compare clinical, metabolic and 
hormonal profile in women of PCOS with normal homocysteine level with that of increased homocysteine level.
Materials and Methods: This is a prospective observational study which will be performed in the department of obstetrics and gynaecology, AVBRH, DMIMS (Deemed to be University, Wardha), a tertiary care teaching hospital situated in the rural area of Wardha district in over 140 patients for period between 2020-22. This study will include PCOS patients based on Rotterdam diagnostic criteria and will exclude patients with known metabolic, cardiovascular and endocrine disorders. Metabolic and hormonal profile will be evaluated with BMI, Lipid profile, Insulin resistance, serum levels of LH, FSH, DHEA and Testosterone in all patients. Serum homocysteine levels will be measured using ELISA.
Expected Results: We expect that there will be significant difference in clinical, metabolic and hormonal profile of PCOS women having hyperhomocysteinemia than women having normal homocysteine level.