European Journal of Molecular & Clinical Medicine

The organophosphorus pesticide, monocrotophos induced toxicity in fish’s adobe has been studied to access the biochemical and hormonal disruption caused in the liver and ovary of the fish. Monocrotophos pose serious risk to biochemical parameters, enzyme activities and level of hormones in the fishes. A direct relationship between concentrations of monocrotophos, elevated cholesterol levels and depressed estradiol concentrations have been traced in the study. The elevated levels of cholesterol in the ovary apparently reflect the reduced rate of its utilization for steroid synthesis by the ovary as significant effect of pesticide. The decreased estradiol level causes decreased production of vitellogenin as well as hampers the development of oocytes in ovary of Cyprinus carpio communis which was also evident in the experiments

Objective to assess the influence of administering the tryptophan in the white male rats Rattus novergicus's testosterone and estradiol hormone levels. This research is experimental with the design of the posttest only control group design. The samples used as many as 28 rats were divided into 4 treatment groups. Each group is given an intraperitoneal injection of tryptophan with a dose level of 40mg, 50mg and 60mg/kg of bady weight. While one group was separated and made as control group. The treatments are given for 14 days and measured hormone levels using RIA. Based on assessment results, it was observed that there was a decrease in the average levels of testosterone (13,78nmol/L) and also observed an increase in the average level of the estradiol (8,65pg/dl) in the male white rat Rattus norvegicus when compared to the control group. The doses of tryptophan administered in the treatment group 1 is 40mg obtained the average testosterone levels 12,95nmol/L and average estradiol level of 9,87pg/dl. The doses of tryptophan administered in the treatment group 2 is 50mg obtained an average testosterone level of 11.03nmol/L and average estradiol level of 10,17pg/dl. The administration of tryptophan caused a decrease in the average testosterone levels in the control group and an increase in the average levels of estradiol compared to the control group even though the increase and decrease in the mean was not significant. It is likely that intraperitoneal administration of tryptophan has inhibitory effect of estradiol on testosterone.