Online ISSN: 2515-8260

Keywords : ferritin

Laboratory Markers Versus Ct Severity Score In Predicting Mortality In Covid 19

B.S.Gopala Krishna; P.Pranay Krishna; V.Ravi Sankar; Kondle Raghu; A.Siva Kumar; M. Srikanth; V. Satyanarayana; P. Siri Priya

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 1824-1831

Aim: Predicting the mortality of COVID-19 with a spectrum of complications is a difficult task for prognostication and management. When individual level data of COVID-19 patients were not yet available, there is a need for risk predictors to support the treatment decisions. The study aims to identify the high accurate marker to measure the prognosis and outcome of COVID19.
COVID-19 course is divided into four stages, according to chest computed tomography (C.T.) progress. The demographics, disease exposure history, clinical condition, laboratory tests, computed tomographic chest scan, and outcome data were collected and measured their correlation to assess the risk predictor.
The 10.4% mortality (n=52) was observed in total population. D-dimer (μg/dL) levels observed as 0.75 ± 0.65 in expired patients. NLR ratio observed as 17.1 in expired patients. Ferritin levels were observed as 49.8 ± 32.5 in expired patients. A D-dimer positive predictive value of 72.5% and a negative predictive value of 88% for a predictor of mortality. Ferritin positive predictive value of 35.5% and a negative predictive value of 76.5% for the predictor of mortality. Hence, the AUC of serum ferritin 0.598 represents the poor ability to discriminate the prediction for the cause of death than D-dimer levels. D‐dimer > 2 μg/dL on admission was associated with in‐hospital death. These main findings indicate that D‐dimer on admission >2.0 μg/dl was the independent predictor of hospital death in patients with Covid‐19. A D-dimer has the highest positive predictive value than serum ferritin levels.
Conclusion: The AUC for D- dimer at admission was 0.880, with an optimal cutoff of 2.2 μg/dL in predicting the cause of mortality. D‐dimer on admission > 2.0 μg/mL (fourfold increase) is the best predict in‐hospital mortality and a helpful marker to improve the management of Covid‐19.

Serum Ferritin And Hepcidin Levels In Hepatitis C Patients

Ali Sami Mohammed; Layla Abd-Al-Sattar Sadiq Laylani; Mostafa Ali Abdulrahman; Mohammed Ahmed Mustafa

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 408-411

The aim of the study detects the relation between serum ferritin and hepcidin with hepatitis C virus One hundred subjects (men and women) were taken in the current study. Forty-four subjects without infection used like control group and fifty-six subjects with hepatitis C virus. The results demonstrate high significant (P < 0.05) elevate in levels of serum ferritin and hepcidin in subjects with hepatitis C compare with health subjects. It was concluded that there is positive relationship between serum ferritin, hepcidin and hepatitis C.

Assessment The Levels Of 25(OH) Vitamin D And Ferritin In Patients With Hypothyroid

Amera Kamal Mohammed; Thanaa Abdulmahdi; Zainab Nasser Nabat

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 23-28

Background: Thyroid hormones are essential and have various effects. For instance, they maintain normal growth and regulate metabolism. Hypothyroidism is a condition where the body doesn’t make enough thyroid hormones and people with hypothyroidism usually have a slower metabolism. The serum ferritin levels and vitamin D levels have been changed in patients with Hypothyroidism.
Objective: a study has been carried out to investigate the association among thyroid disorder and the levels of both vitamin D and ferritin.
Materials and Method: The BMI was calculated using the formula BMI= weight (kg)/ height2 (m)2. Vitamin D (25-hydroxyvitamin D), ferritin, T3, T4 and TSH levels were measured using the ELFA (Enzyme Linked Fluorescent Assay, Model: bioMérieux). the results were analysed using SPSS package (version 18).
Results: The results indicated that the age of participants played an ignorable role in this investigation, while significant increases (P<0.05) differences were noticed between the patients and controls in terms of BMI, 25(OH) vit D, ferritin, TSH, T3 and T4. There was also a significant difference(P<0.05) between male and female patients in terms of ferritin, TSH, T3 and T4 in comparison with the controls.
Conclusion: The low levels of Vitamin D and Ferritin concentration were associated with the Patients of hypothyroidism