Online ISSN: 2515-8260

Keywords : GBS

Pattern of GBS in Kashmir, a Northern Region in India

Irfan Yousuf wani, Zhahid Hassan, Tanveer Hassan baba, Summyia Farooq , Iqra Mehraj

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 1218-1225

Background: Guillain-Barré syndrome (GBS) is said to be most common cause of acute flaccid paralysis worldwide. It is also one of the important life-threatening emergencies requiring critical cares in neurology. There are many subtypes of GBS like acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonopathy (AMAN) and acute motor sensoryaxonopathy (AMSAN).  GBS shows a lot of variation in the demographic variables like gender distribution and seasonal variation as seen in different studies. The frequency of different variants of GBS is also quite variable. AIDP is more common in Europe and North America whereas axonal subtypes are more often seen in Asia and South America. We conducted this study over a period of Two years to determine these features of GBS in our population.
Material and Methods:92 patients comprising of 49 male and 43 female patients were included in this study. All these patients were admitted in our hospital and were evaluated as per the established protocol. Baseline investigations were done in all the patients. Neurophysiology and CSF analysis was also done.
Results: In our study we found that most of the patients had AIDP. A preceding precipitating event was present in 31 patients. There was a significant seasonal variation in our population with majority of the cases occurring in spring season.  We also found that there were a significant number of patients who presented to us in postpartum period.
Conclusion: This study shows that knowing the demographic variations of GBS patients of a region is important so as to prepare the healthcare facilities for better management of such cases.

A study on clinical profile of Landry Guillain Barre syndrome

Dr. Thomas Mathew, Dr. Sheela Jacob

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 12010-12014

The major clinical manifestation is weakness which evolves more or less symmetrically over a period of several days to four weeks. Proximal as well as distal muscles are involved with lower extremities being involved earlier than the upper. Trunk, intercostal, neck muscles and cranial nerves are affected later. All adult patients, diagnosed as Guillain-Barre Syndrome, who strictly complied with the NINCDS criteria, admitted to medical college hospital were included in this study. This includes a retrospective study of four years and prospective study of one year. Ninety seven patients entered the study. In our study, 52 (53.6%) patients had cranial nerve involvement. 7th, 9th and 10th Cranial nerves and the nerves supplying ocular muscles, were commonly affected in the descending order given. Seventh nerve was involved in 32 (33%) patients and out of this 7 patients had unilateral involvement