Online ISSN: 2515-8260

Keywords : dopamine

Role Of Exercise Induced Dopamine Replica On The Expression Of Intrinsic And Extrinsic Apoptotic Signalling In Human Melanoma Cell Line (A375)- In-Vitro Study

Aashiq Mohamed P; Lavanya Prathap; Selvaraj Jayaraman; Preetha. S

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 593-603

Exercise has been implicated in modulating dopamine in a major amount as neurotransmission, increasing blood flow, etc. The role of exercise in tumor risk reduction, there is now convincing and vital evidence that exercise reduces melanoma and also other tumors. This has to be practiced in each and every place where tumor has grown. The goal of the study is to study the impact of exercise induced dopamine replica in modulating the apoptotic signaling pathway in human melanoma.
The melanoma cell line of human cell (A375) was brought from NCCS, Pune, India. Cell viability test and Gene expression analysis were carried out using MTT and PCR respectively. The results were analyzed using appropriate statistical tools using ANOVA and Duncan’s  test.