Online ISSN: 2515-8260

Keywords : nerobol


TO THE MECHANISM OF THE REGULATORY ACTION OF ECDISTEN AND NEROBOL ON THE PROCESSES OF PROTEIN SYNTHESIS IN THE BODY OF HIGHER ANIMALS

Vladimir Nikolayevich Syrov, Gulnara Abdullaeyvna Shakhmurova, Zaynab Abdurakhmanovna Khushbaktova

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 330-337

A comparative study of the regulatory effect of the preparation of ecdisten
(created based on the phytoecdysteroid ecdysterone) and nerobol (a synthetic anabolic
preparation) on protein biosynthesis was carried out in mammals (mice) in in vivo and in vitro
experiments. We have defined that the activation of protein-synthesizing processes by ecdisten
in the organism of higher animals is not associated with its effect on the synthesis of mRNA,
but is only a reflection of the acceleration of translational processes. The corresponding
action of Nerobol is directed primarily at transcription processes with subsequent generalized
stimulation of the synthesis of protein macromolecules at the cytoplasmic level due to an
increase in the number and activity of polyribosomes.