Online ISSN: 2515-8260

Keywords : hypophosphatemia

Evaluation of abnormal serum electrolytes in asthmatics

Dr. Vijaya Lokary, Dr. Christy Pradeep Raj D, Sivajyothi Boda, Dr. Ramya Sree A, Dr. M Madhulatha

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 3599-3606

Airway inflammation and hyper reactive bronchial tissue are hallmarks of bronchial asthma. The purpose of this study was to compare the blood serum electrolyte values of patients with asthma to those of a healthy population in order to establish if there is a distinction between those with intermediate asthma and those with persistent asthma.
Methods: This case-control study focused on asthma patients treated at Department of Respiratory Medicine, Mamata Medical College and General Hospital, Khammam, Telangana, India. Twenty patients with both mild and severe cases of asthma were randomly assigned to groups with healthy sex-and age-matched subjects, and both groups were monitored for six months. No attempt was made to determine if secondary electrolyte disturbances might have been involved. Serum blood samples could be analysed to reveal sodium, potassium, magnesium, calcium and phosphorus levels.
Results: The results showed that those with sporadic symptoms were significantly different from those with persistent symptoms (P 0.001). The prevalence of hypomagnesemia and hypokalemia was highest in the persistent and intermittent asthma groups, respectively, in the asthma patient population. The effects of low sodium, calcium, and phosphorus levels were negligible.
Conclusion: Asthma patients tend to have abnormal concentrations of sodium, potassium, magnesium, calcium, and phosphate, the study's authors concluded. Asthma patients typically had low magnesium levels and high potassium levels. Overall, the serum potassium, sodium, and magnesium levels were found to be higher in the group with intermittent asthma than in the group with persistent.

Factors Involved in Predisposing Children with Critical Illness to Eventually Develop Hypophosphatemia at Zagazig University Hospitals

Dina Gamal Abdel Mohsen, Nahed Khater, Dalia A. Rahman , Abeer Abd Alla

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 405-414

Background: Hypophosphatemia is a metabolic disorder that can have significant
consequences and is frequently undiagnosed in critically ill children. While
hypophosphatemia is typically characterized by nonspecific symptoms such as
weariness and irritation, severe hypophosphatemia (less than 1.0 mg/dl) can result
in much more severe complications including such decreased diaphragmatic
contractility and cardiac arrhythmias.
Aim of the Study: Determine the prevalence of hypophosphatemia in critically ill
children, as well as the clinical consequences and risk factors associated with the
condition throughout patients' admission in the PICU.
Patients and Methods: A case-control study that was conducted over a period of one
year, from July 2019 to June 2021, at PICU of Pediatrics Department, Zagazig
University Hospitals.The study included 180 subjects that were classified into two
groups, each of 90 subjects as follows; patients group, which included 90 cases, and
the control group, which included 90 healthy infants and children.
Results: There was a statistically significant difference in weight, height percentile,
ESR and CRP, hemoglobin level, TLC, PT, INR, alkaline phosphatase a serum,
serum creatinine, PH, serum phosphorus level, presence of hypophosphatemia
(20%), number of patients with hypophosphatemia, percent change in serum
phosphorus, as well as percent change in serum phosphorus between the studied
Conclusion: In our investigation, the obvious probable source of hypophosphatemia
was prolonged TPN decision-making as well as sepsis. In the PICU, mild to moderate
hypophosphatemia occurred. Hypophosphatemia was related with an increased
length of stay in the PICU and poor outcomes.