European Journal of Molecular & Clinical Medicine

A rare chronic inflammatory disorder with no known cause, Kimura disease (KD) is typically found in young Asian males. The condition is characterized by frequent enlargement of the salivary glands and a painless subcutaneous swelling in the head and neck region. Elevated immunoglobulin E (IgE) levels and eosinophilia in the blood and tissues are frequently associated. Eosinophilic infiltrates, follicular hyperplasia, and postcapillary venule proliferation are typical histological findings of biopsy specimens taken from subcutaneous swellings or lymph nodes. Even so, the course is typically benignly waxing and waning. A patient who receives an early diagnosis may avoid needless intrusive procedures. In this article, we describe a case of KD in a 40-year-old man who had two surgical procedures for subcutaneous edema in the left submandibular region before being  reassessed and finally diagnosed  as KD  in 2022, based  upon peripheral blood eosinophilia, raised serum IgE levels and histopathological
findings. He subsequently made a good recovery on oral steroids.

Objectives:

To estimate IgE and histamine levels in patients with drug allergy and with past history of drug     allergy.
Compare these levels with that of normal individuals
Assess the association of demographic factors, nature of drugs and clinical presentation with IgE and histamine levels. 

Methodology: 113 potential participants were totally interviewed. 66 selected based on selection criteria. 22 had current allergy (CA), 22 past history of allergy (PA) and 22 without any allergy (NA). Study was initiated after getting IHEC approval and informed consent from each participant. Estimation of serum IgE and histamine was done using ELISA kits. Demographic details, details of drugs and clinical presentation were recorded. Time interval between onset of allergy and estimation of IgE and histamine was recorded for patients with PA. Results were analyzed using ANOVA and student t test. p<0.05 was considered significant. 
Results: IgE and histamine levels were significantly higher in CA compared to NA and PA subjects.
Normal mean level IgE was 72.6 IU/ml and histamine 42.53 ng/ml. In PA levels were higher than that of NA but lower than CA. Males and civil workers had a higher level than females. Age related difference in the levels was not observed. NSAIDs induced allergy resulted in maximum elevation of IgE (538.74
IU/ml) and histamine (158.32 ng/ml) followed by antimicrobials (IgE 395.97 IU/ml) and histamine
(133.42 ng/ml ).Patients who developed maculopapular rashes had maximum level of IgE (627.87 IU/ml) and histamine (182.25 ng/ml). The time dependent decline in both the levels was observed in PA.
Higher IgE level was associated with higher level of histamine in all the groups.
Conclusion: In CA, NSAIDs and maculopapular rashes resulted in maximum elevation of IgE and histamine. In PA, IgE level was higher than NA group. Whether estimation of IgE would indicate past allergy or the tendency to develop allergy has to be assessed by further studies with large samples.

Background: Hypersensitivity to cow milk proteins is one of the main food allergies
and affects mostly but not exclusively infants, while it may also persist through
adulthood and can be very severe. Different clinical symptoms of milk allergy have
been established. The diagnosis of milk allergy differs widely due to the multiplicity
and degrees of symptoms, and can be achieved by skin or blood tests. The aim of
this study to assess the role of cow milk (CM) to induce asthma and compare
between the presence of cow milk protein allergy in asthmatic and non-allergic
children and to prevent occurrence of asthma among children, Subjects and
methods: This is a case control study, was conducted on 154 patients divided into
two groups (77 in each). This study was conducted in Pulmonology Unit of
Pediatric Department in Zagazig University Hospital. Result: There was high
statistically significant difference between the two studied groups as regards skin
pick test. There was high significant increase in the severity recorded in respiratory
function test in allergic group compared to control group. Conclusion: our study
showed that CMA can exacerbate the symptoms in children with asthma. Therefore,
it is worth considering a possible role of food allergy in asthma in young children,
particularly when asthma is not adequately controlled in spite of proper routine
management. Although SPT seemed to be more reliable than sIgE testing, both had
suboptimal reliability. A definite decision should depend on performing a titrated
oral challenge test.