Online ISSN: 2515-8260

Keywords : T3

Study of Serum Calcium, Magnesium and Phosphorous Levels in Hypothyroidism

Bonala Sharat Babu, Azmatulla Shaik, Md. Siddique Ahmed Khan, Naveed Altaf

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1286-1292

Background: Thyroid disorders are the most common endocrine abnormality in the
world secondary to diabetes mellitus. Thyroid hormones are essential for growth,
neuronal development, reproduction and regulation of energy metabolism. It influences
the metabolism of all substrates including minerals. Many studies have shown that
mineral metabolism is frequently disturbed in thyroid disorders.
Materials and Methods: The study was conducted on sixty newly confirmed
hypothyroid cases based on the thyroid profile and sixty euthyroid cases were recruited
as controls. Blood samples were collected from all the patients for the estimation of
serum T3, T4, FT3, FT4, TSH, calcium, phosphorus and magnesium by auto analyzer
method. Modified spectrophotometric micro-method was used to measure Serum
copper using Bathocuprine Disulphonate Disodium Salt (BCDS) and Guanidine
hydrochloride salt. The Statistical software namely SPSS 18.0, and R environment
ver.3.2.2 were used for the analysis of the data.
Results: It was found that the levels of serum sodium, potassium and calcium were
significantly decreased in cases than the controls. Serum magnesium and phosphorus
were significantly elevated in cases than controls.
Conclusion: Serum calcium, magnesium and phosphorous levels are significantly
altered in patients having hypothyroidism. Thyroid diseases have wide spread systemic
manifestations including their effects on bone and mineral metabolism. Also thyroid
hormone affects the glomerular filtration rate, renal blood flow, tubular reabsorption
and excretion of minerals which have direct effect on Calcium, Magnesium and
phosphorous level. Thus monitoring of these minerals in hypothyroid patient will be of
great benefit in improving clinical manifestation and can be treated appropriately.

Thyroid Dysfunction Prevalence in Elderly Patients with Chronic Liver Disease in Zagazig University

Mohamed Mohamed Hassaan, Zeinab Maher Mohamed, Aya Hefny Ibrahem, Mayada Mohamed Mousa

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 493-502

Background: Cirrhotic patients are more liable to thyroid dysfunction especially
hypothyroidism and may have thyroiditis and hyperthyroidism. The aim of this
work is the evaluation of thyroid dysfunction in elderly patients with chronic liver
disease. Patients and methods: A cross-sectional study included 54 elderly patients
with clinical, biochemical, and ultrasound evidence of cirrhosis of liver which was
carried out in Internal Medicine Department, Faculty of Medicine, Zagazig
University Hospitals. All subjects included in this study were elderly over 65 years
and subjected to through clinical examination and full history taking with special
stress on age, sex, comorbidities, medications, symptoms of hepatic decompensation
and symptoms of hypothyroidism or hyperthyroidism. The technical part was done
at Biochemistry Department in Zagazig University. We assessed complete blood
count, serm bilirubin, serum albumin, serum ALT and AST, serum creatinine,
serum urea, PT, PTT, INR, TSH, free T3, T4 and lipid profile. Results: There was a
statistically significant positive correlation between serum TSH and weight, BMI,
Child score, total, direct bilirubin, INR, serum cholesterol, LDL cholesterol and
triglycerides. There is significant negative correlation between TSH and total
leucocytic count, platelet count, serum albumin. There was a significant negative
correlation between free T4 and both weight and BMI. There is significant positive
correlation between free T3 and total leucocytic count, and platelet count. There is
non-significant correlation between free T3 and neither weight, BMI, age,
hemoglobin, serum albumin, serum creatinine, ALT, AST, INR, LDL or HDL
cholesterol There was a significant negative correlation between child score and
TSH while there is significant positive correlation between child score and both Ft4
and FT3. There is significant relation between presence and degree of ascites and
all of free T4, free T3 and TSH. Conclusion: There is important relation between
Child pough class and all of free T4, free T3 and TSH. There is significant relation
between grade of hepatic encephalopathhy and all of free T4, free T3 and TSH.