Online ISSN: 2515-8260

Keywords : SGPT

A comparative Study of Liver enzymes and hematological parameters indenguefever casesandhealthycontrols

Dr Mahantesh BB,Dr KavithaMM , Dr Subhash N, Dr SangappaVK

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 156-160

Dengue is the most serious viral infection in recent years, resulting in major morbititesand mortality. This was a hospital based comparative study done from July – August2019. The purpose of this study was to estimate the hematological parameters and liverenzymes in dengue patients which could help to detect the severity of the
disease andintervene early. Participants included 75 cases and 75 healthy controls. Hemoglobin,WBC count, Platelet count along with SGOT and SGPT levels were analysed. Our studyshowed elevated SGOT AND SGPT levels of which SGOT is more elevated .WBC andplatelet count were reduced and showed negative correlation with
SGOT and SGPTvalues.Hence thisstudyshowedliver enzymesget affected by dengue and also itssever ity can beassessed by knowing hematological parameters which aids in early intervention and initiatethetreatment sooner.

An Observational Study of the Effect of Laparoscopic Cholecystectomy on Liver Function Test

Hari Om Dhaker, Shyam Bhutra, Yogendra Singh Chundawat, Naresh Kumar, Nani Dhaker, Saranshi Singh

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2308-2314

Background: Cholecystectomy is a common treatment of symptomatic gallstones and other gallbladder conditions. As it gained worldwide popularity, it has become one of the most common operations performed in general surgical practice. In this study we aimed to investigate to determine changes in liver function tests after laparoscopic cholecystectomy.
Material & Methods: A prospective observational study done on 100 patients who underwent elective laparoscopic cholecystectomy were taken up for the study in the department of General surgery at JLN medical college and hospital, Ajmer, Rajasthan, India during period between January 2020 to December 2021. All patients who gave consent for the study underwent a standard clinical and laboratory evaluation including USG. Pre-operative investigations included liver function tests i.e. prothrombin time, bilirubin (total and direct), alanine transaminase, aspartate transaminase, alkaline phosphatase, total proteins, serum albumin, GGT, and LDH. The subjects under inclusion criteria have taken up for the study. The liver function tests have repeated 24 hours, 3rd day, 7th days, 10th days after the operation and compared.
Result: The mean age of the study population was 43.3 years with a standard deviation of 13.35 yrs. A negative t-STAT shows that the value of serum total protein, serum albumin was falling after the laparoscopic procedure. A statistically significant increase in the bilirubin(total and direct), SGOT, SGPT, GGT, LDH, and serum alkaline phosphatase levels were noted after laparoscopic cholecystectomy and no statistical significance in prothrombin time.
Conclusion: We concluded that statistically significant increase in the bilirubin (total and direct), SGOT, SGPT, GGT, LDH, and serum alkaline phosphatase levels after Laparoscopic cholecystectomy. There was a decrease in total protein and albumin and no change for prothrombin time. However, further studies with larger sample sizes and multi-center trials would yield more definite results, along with meta-analyses. We strongly suggest the consideration of confounding factors such ascomorbidities, duration of surgery, CO2 pressure, utilized anesthetic agents, and also longer period follow-ups. 


Pradeep Kumar Gupta; Himanshu Agarwal; Saurabh Singhal; Keerti Manocha

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1169-1173

Aim: To find the level of uric acid in patients of chronic liver disease and its correlation, if any, with etiology
and other parameters.
Materials and Method: This was a prospective study conducted on North Indian population admitted in
Department of Medicine during the period of 2020 and 2021. A total number of 50 patients diagnosed with
chronic liver disease were included in this study. A detailed history was elicited from the patients regarding
their present complaints; associated symptoms; alcohol intake, smoking, previous history of hypertension,
diabetes mellitus, arthritis, hypothyroidism, any cardiac illnesses and chronic drug intake. All patients
underwent an ultrasonogram abdomen and estimation of serum uric acid levels. Waist circumference in males
and females was measured. Glycemic and Body mass index were recorded. Serum uric acid level was sent for
analysis on the day of admission and was followed up.
Results: Out of 50 subjects, 38 (76%) were males and 12 (24%) were females. Mean ± SD uric acid (mg/dl)
among the study subjects was 6.69±2.92. Normal uric acid (3.1-5) was revealed among 24% of the subjects
while higher uric acid/hyperuricemia was reported among 38 (76%) subjects. Mean uric acid was 4.03, 5.17
and 8.94 among the subjects having CTP class A, B and C respectively. Pearson correlation analysis revealed
significant positive correlation between uric acid and total bilirubin, SGOT, SGPT and CTP Score.
Conclusion: Elevated serum uric acid level might be a risk factor for the incidence of chronic liver disease.
Hyperuricemia may act as a surrogate marker for assessing the prognosis of CLD.