Online ISSN: 2515-8260

Keywords : hyponatremia


PRESENCE OF HYPONATREMIA IN PULMONARY TUBERCULOSIS AMONG PARTICIPANTS IN A TERTIARY CARE CENTER

Dr Shefil sharaf , Dr Irfan kandal

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 1266-1276

Tuberculosis (TB) is one of the major public health problems in Pakistan. Our country ranks fifth in tuberculosis high, burden countries worldwide. Hyponatremia is considered as one of the most common and important electrolyte abnormality in Pulmonary TB (P TB) patients. This study will show the prevalence of hyponatremia in PTB in our population. This study was planned to determine the presence of hyponatremia in pulmonary tuberculosis among adults and to correlate its severity.

Evaluation of abnormal serum electrolytes in asthmatics

Dr. Vijaya Lokary, Dr. Christy Pradeep Raj D, Sivajyothi Boda, Dr. Ramya Sree A, Dr. M Madhulatha

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 3599-3606

Airway inflammation and hyper reactive bronchial tissue are hallmarks of bronchial asthma. The purpose of this study was to compare the blood serum electrolyte values of patients with asthma to those of a healthy population in order to establish if there is a distinction between those with intermediate asthma and those with persistent asthma.
Methods: This case-control study focused on asthma patients treated at Department of Respiratory Medicine, Mamata Medical College and General Hospital, Khammam, Telangana, India. Twenty patients with both mild and severe cases of asthma were randomly assigned to groups with healthy sex-and age-matched subjects, and both groups were monitored for six months. No attempt was made to determine if secondary electrolyte disturbances might have been involved. Serum blood samples could be analysed to reveal sodium, potassium, magnesium, calcium and phosphorus levels.
Results: The results showed that those with sporadic symptoms were significantly different from those with persistent symptoms (P 0.001). The prevalence of hypomagnesemia and hypokalemia was highest in the persistent and intermittent asthma groups, respectively, in the asthma patient population. The effects of low sodium, calcium, and phosphorus levels were negligible.
Conclusion: Asthma patients tend to have abnormal concentrations of sodium, potassium, magnesium, calcium, and phosphate, the study's authors concluded. Asthma patients typically had low magnesium levels and high potassium levels. Overall, the serum potassium, sodium, and magnesium levels were found to be higher in the group with intermittent asthma than in the group with persistent.

A CASE OF VIRAL MENINGITIS WITH CHRONIC SIADH PRESENTING WITH SEIZURES.

Dr G S Sanjay Surya Dr Priya Venugopalan Dr Gowtham Hanumanram Dr Kannan Rajendran Dr Gowrishankar A

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 63-66

A 67yrs old male hypertensive on irregular treatment presented to emergency room in a drowsy state. Patient had history of one episode of generalized tonic clonic seizures with altered sensorium ,   evaluated and was found to have chronic hyponatremia. Fever, throat pain, fatigue and vomiting were also present. A history of fever and multiple vesicles over body , CSF analysis , TZANC smear positive with multiple varicella zoster lesions were pointing towards viral meningitis . Patient was treated for viral meningitis with acyclovir and he improved significantly. Thus , here we report an interesting case of viral meningitis with chronic SIADH presenting with seizures

Assessment of prescribing patterns of medicines in chronic kidney disease patients

Dr.Mohit Patnaik

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 4263-4267

Background: Chronic kidney disease (CKD) is characterized by progressive decline in glomerular filtration rate (GFR). The present study was conducted to assess prescribing patterns of medicines in chronic kidney disease (CKD) patients.
Materials & Methods: 78 patients of CKD of both genders were assessed for clinical profile, drug usage patterns, and medication-related problem. Suspected adverse drug reactions (ADRs) were recorded.
Results: Out of 78 patients, males were 30 and females were 48. Cardiovascular drugs used by patients was diuretics in 24, ACE inhibitors in 10, calcium channel blocker in 8, beta blockerin 6, gastrointestinal drugs such as H2 blockers in 12, proton pump inhibitor in 4, Hematopoietics such as iron in 2, folate in 3 and erythropoietinin 4, antibiotics such as cefoperazone          in 2, levofloxacin in 1 and ceftriaxone in 2 patients. The difference was significant (P<0.05). Adverse drug reactions observed were hyponatremia in 25%, hypokalaemia in 14% and hypoglycaemia in 8% patients. The difference was significant (P< 0.05).
Conclusion: Common administered drugs in patients with chronic kidney disease was cardiovascular drugs followed by gastrointestinal drugs, hematopoietics and antibiotics. Common adverse drug reactions observed were hyponatremia, hypokalaemia and hypoglycaemia.