Online ISSN: 2515-8260

Keywords : Oral disease

Type of Article: Review TITLE: ROLE OF CATHEPSIN IN ORAL DISEASE – A review

Dr. Lalli Dharmarajan; Dr. E.P. Sridevi Anjuga; Dr. Pradeep P Elango; Dr. N. Aravindha Babu MDS

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 1479-1485

Cathepsins are a class of globular lysosomal proteases that are known to be responsible for protein degradation. They have many biological roles besides proteolysis, such as apoptosis wound healing angiogenesis, proenzymatic activation, bone remodeling, and resorption. The role of cathepsins in pathogenesizing systemic diseases such as cancer, bronchial asthma, atherosclerosis, neurological disorders, rheumatoid arthritis and osteoarthritis has been involved. This review emphasizes the role of cathepsins in multiple oral diseases such as periodontitis, odontogenic cysts, ameloblastoma, tumors of the salivary glands and malignant melanoma

Role Of Microbial Products In Dental Diseases: A Mini Review

Binay Sharma; Arun Karnwal

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 3016-3026

The oral cavity being the centre of array of organisms, endorses the establishment of diverse microbial associations like on the mucosa and teeth. Metabolism of these living beings encourages the attachment and development of the ensuing colonisers. A fragile adjust is kept up within the microbial ecosystem, with these life form conferring to normal growth and defences. Nevertheless, any change or disturbance within the microbial outline by reason of either outward or inborn components results unfavourable shift towards pathogenic organisms provoking numerous diseases such as dental caries or periodontitis. Moreover, current exposures also reveal that these microbes induce systemic illnesses such as diabetes or artherosclerosis. This article is an endeavour to confer an overview of the changed flora ailing states.