Online ISSN: 2515-8260

Keywords : Granisetron


Comparative Study of Ondansetron and Granisetron for Postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy under general anaesthesia –Randomized double blind study

Dr. Rajini Sathanish Dr. Rashmi V Bengali Dr. Kalidass Dr. S Amuthan

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 2556-2562

Postoperative nausea and vomiting is (PONV) a very distressing complication and preventive measures are justified when the risk of PONV is very high. Ondansetron is the first 5-HT3 antagonist used alone or in combination for prophylaxis of PONV due to its lower cost. Granisetron is recently introduced 5-HT3 antagonists with greater affinity for 5-HT3 receptor and having longer half-life. Aim of the present study is to compare the antiemetic efficacy of ondansetron, granisetron in high-risk patients undergoing laparoscopic cholecystectomy under general anaesthesia. Method: This study was prospective and randomized one. Written informed consent will be taken from patients in both groups. Patients will be kept NPO for 12 hours before surgery. In the preoperative room, iv line will secured. In the operation theatre ASA Standard monitoring devices pulse oximetry, NIBP, ECG will be attached and baseline blood pressure, heart rate and O2 saturation values will be recorded. Later capnograpy will be attached after the intubation.

A CONTROLLED, RANDOMIZED, DOUBLE BLIND, FIXED DOSE COMPARATIVE STUDY TO EVALUATE THE EFFICACY OF GRANISETRON, ONDANSETRON AND METOCLOPRAMIDE IN PREVENTION OF POST-OPERATIVE NAUSEA AND VOMITING IN GYNECOLOGICAL ONCOSURGERIES

Dr. Sumitha CS, Dr. Gifty Susan Philip, Dr.Mamatha HS, Dr.Rachana ND, Dr. Rashmi NR, Dr. Arathi BH,Dr. Shashidhar GS, Dr. LingegowdaKB

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1570-1577

The etiology of PONV is not fully understood. PONV is multifactorial in etiology and depends on a variety of factors like, age, gender, previous history of PONV, type and duration of operation, anaesthesia technique and postoperative care.10So as an anesthesiologist it is essential to understand the mechanism involved in nausea and vomiting and the available peri-operative treatment options. After Institutional Ethical Committee approval, one hundred and twenty females aged 18-60yr of ASA I and II who satisfied the inclusion criteria were randomly allocated into four groups of 30 each by a computer generated random number table. There is statistically significant difference in incidence of vomiting among the groups over the study period in total (p value is 0.010), but no significance in the case of nausea among the groups (p value is 0.103).