Online ISSN: 2515-8260

Keywords : vomiting

A study on clinical profile of patients with dengue fever at a tertiary care hospital

Dr. Khizerulla Sharief, Dr. Pragalatha Kumar, Dr. Ayas Ahmed, Dr. Chetan Kerur

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 5, Pages 196-199

During the 19th century, dengue was considered a sporadic disease, causing epidemics. However, dramatic changes in this pattern have occurred and currently, dengue ranks as the most important mosquito-borne viral disease in the world. In the past 50 years, its incidence has increased 30-fold with significant outbreaks occurring in five of six World Health Organization (WHO) regions. The study was approved by the institutional ethical committee. Informed written consent was obtained from the parents of each patient before enrollment. History and examination findings were recorded in a pre-structured proforma. Children with clinically diagnosed dengue fever (WHO criteria) & serologically confirmed and admitted cases between the age group of 2months to 18years formed the study group. In my study population, all of them had a fever. The second most common presenting symptom was vomiting 112 (60.5%) cases, pain abdomen was next 73 cases(39.5%), 56 cases (30.3%) presented as a shock, 18 cases (9.7%) presented with bleeding manifestations and least being headache with 9cases (4.9).

Comparative Study of Ondansetron and Granisetron for Postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy under general anaesthesia –Randomized double blind study

Dr. Rajini Sathanish Dr. Rashmi V Bengali Dr. Kalidass Dr. S Amuthan

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 2556-2562

Postoperative nausea and vomiting is (PONV) a very distressing complication and preventive measures are justified when the risk of PONV is very high. Ondansetron is the first 5-HT3 antagonist used alone or in combination for prophylaxis of PONV due to its lower cost. Granisetron is recently introduced 5-HT3 antagonists with greater affinity for 5-HT3 receptor and having longer half-life. Aim of the present study is to compare the antiemetic efficacy of ondansetron, granisetron in high-risk patients undergoing laparoscopic cholecystectomy under general anaesthesia. Method: This study was prospective and randomized one. Written informed consent will be taken from patients in both groups. Patients will be kept NPO for 12 hours before surgery. In the preoperative room, iv line will secured. In the operation theatre ASA Standard monitoring devices pulse oximetry, NIBP, ECG will be attached and baseline blood pressure, heart rate and O2 saturation values will be recorded. Later capnograpy will be attached after the intubation.

Study of relative frequency, causes and clinical presentation of pathological swellings of epigastric region

Dr. Abhishek Vats, Dr. Abhishek Yadav, Dr. Ajay Bahadur Singh, Dr. Parkar Zainuddin Liyakat, Dr. Radhika Sahni, Dr. Prakhar Verma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 12044-12052

Introduction: Swelling in the epigastrium is caused by those organs anatomically present in the region as well as by other organs in the other regions. This study was done with an interest to know the clinical presentation of the various cause of the epigastric swelling.
Methods: Fifty-two cases with a pathological swelling in the epigastrium, who were admitted to tertiary care center, were randomly selected those cases were studied during their stay in the hospital. In this study, the swelling from stomach and pancreas were included aged more than 12 years and the rest excluded. Relevant investigations were made and the diagnosis confirmed.
Results: There were 16 cases of pancreatic swellings and 11 cases of stomach swellings. Carcinoma stomach and pseudocyst each 21%, secondaries 17%, carcinoma pancreas 9.6%. Symptoms were Nausea (61.53%), pain (55.76%), vomiting (51.95%), weight loss (40.38%), fever (34.61%), anorexia (32.69%).
Conclusion: In this study, the most common swelling was the carcinoma stomach and pseudocyst of pancreas. Most common symptom was nausea, followed by pain, weight loss. The least common symptom was gastrointestinal bleeding


Dr.Rashmi Ravindranathan, Dr.Padmanabha Kaimar

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1608-1613

Background: The physiological changes of pregnancy deem nausea and vomiting infallible complications associated with obstetric anaesthesia, resulting in significant morbidity and longer recovery time. The aim of our randomised control trial was to investigate the efficacy of propofol in addition to the currently accepted regimen of ranitidine and metoclopramide in the prevention of nausea and vomiting in this high risk group undergoing spinal anesthesia during caesarean section.
Methods: Eighty fasted term pregnant women scheduled for elective caesarean section were given ranitidine 150mg and metoclopramide 10mg orally 2 hours prior to spinal anaesthesia following which they received either propofol 200µg /kg IV or placebo as a single bolus dose. Intraoperative and post-delivery emetic episodes experienced were recorded at intervals and the intensity of nausea was assessed using the visual analogue scale (VAS).
Results: The incidence of nausea during the intraoperative period in propofol group was 5 % as compared with placebo group in which it was 32.5%, while that of vomiting in propofol group was 5% as compared with placebo group in which it was 22.5%. Both were found to be statistically significant (p= 0.002, p= 0.023 respectively). The incidence of nausea and vomiting during the entire postoperative period of 0-24 hours between the two groups was found to be statistically insignificant.
Conclusion: The prophylactic administration of a subhypnotic dose of propofol with ranitidine and metoclopramide was effective in the prevention of nausea and vomiting after neuraxial blockade during the intraoperative period but not during the postoperative period.