Online ISSN: 2515-8260

Keywords : Pulmonary Tuberculosis


Role of HRCT chest in correlation of pulmonary tuberculosis with tuberculous spondylodiscitis

Dr. Ravi Soni, Dr. Suhail Khan, Dr. Bharat Jain, Dr. Shrinidhi Kulkarni, Dr. Monica Satyam, Dr. Kapil Vyas

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 897-903

Tuberculosis is a contagious bacterial infection which primarily affects the lung parenchyma
but it can affect any other part of the body. Mycobacterium tuberculosis complex is mainly
responsible for majority of cases in India and worldwide, but other species are also
responsible for causing tuberculosis among which includes M. bovis, M. africanum, M.
microti, M. Canetti. We retrospectively reviewed 40 patients of histologically or
microbiologically proven diagnosis of TB spondylitis from the time period of January 2020 to
October 2021 in the Radio-Diagnosis and Imaging Department of Pacific Medical College
and Hospital, Udaipur, Rajasthan, India. Findings such as cavitation, consolidation, tree in
bud opacities, miliary nodules are suggestive of pulmonary tuberculosis. Out of 5 patients
suffering from active pulmonary tuberculosis, cavitation was seen in 20% (1 patient) on chest
skiagram whereas 40% (2 patients) showed cavitation on HRCT chest. Consolidation was
seen in 60% (3 patients) on chest skiagram whereas it was seen in 80% (4 patients) on HRCT
chest.

Assessment of fluoroquinolone resistance among pulmonary tuberculosis patients

Harish Chander Marwah

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1624-1628

Background:Tuberculosis is most commonly found among people living in poor
conditions and in deprived areas, especially in elderly people and those with unstable
social or psychiatric backgrounds, such as hostel dwellers, street dwellers, alcoholics,
and drug misusers, as well as in immunocompromised patients.The present study was
conducted to assess fluoroquinolone resistance among pulmonary tuberculosis patients.
Materials & Methods:58 pulmonary TB patients of both genders were included. All
patients were subjected to DST for first-line drugs (FLDs) and second-line drugs. FQs
DST was also performed using automated Mycobacterial Growth Indicator Tube-960
liquid culture technique. The immunochromatographic assay was performed to
distinguish Mycobacterium tuberculosis complex (MTBC) from non-MTBC
Results: Out of 58, males were 38and females were 20. One drug resistance such as
Ofloxacin was seen in 28, levofloxacin in 3 cases, moxifloxacin in 1 and Kanamycin in 1
case. Two drug resistance such as Kanamycin+ Ofloxacin in 2 and Levofloxacin+
Ofloxacin in 1 case. Three drug resistance such as Ofloxacin+
Levofloxacin+Moxifloxacin in 1 and Ofloxacin+ Levofloxacin+ Kanamycin in 1 case and
all sensitive isolates was seen in Ofloxacin+ Levofloxacin+ Kanamycin+ Moxifloxacin in
20 cases. The difference was significant (P< 0.05).
Conclusion: Fluoroquinolone resistance among drug sensitive and multidrug resistance
tuberculosis isolates was high

A Study of Serum Magnesium levels in Pulmonary Tuberculosis

Manjunath M, Krupashree G, Sushma S Biradar , Mohammed Nizamuddin Attar .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11023-11029

Background: Tuberculosis, a public health emergency, has continued to be burden for society both in terms of mortality and morbidity. Once diagnosed, the follow up for assessment is usually done clinically or methods which are not very effective or require expertise.

Study of the diagnostic yield of sputum CBNAAT in HIVpositive clinically suspected pulmonary tuberculosis

Dr. HallyKaribasappa,Dr. Ann Elias

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 925-930

The main reason for this high mortality is the lack of proper diagnosis at the right time. This
is particularly important in patients with HIV and TB co-infection; especially with extra
pulmonary TB as the detection rates are low. There is an urgent need to implement newer
diagnostic modalities for the detection of TB especially in highly HIV prevalent areas.
Patients satisfying inclusion criteria i.e. HIV positive patients clinically and/or radiologically
suspected of pulmonary tuberculosis whose sputum AFB is reported negative were subjected
for CBNAAT. This was done with the intention of identifying yield of CBNAAT over
microscopy. Among patients with abnormal chest x-ray, 84.6% had positive CBNAAT while
in those with normal chest X-ray, 81.1% had negative CBNAAT. Hence majority of patients
with abnormal chest X-ray findings had positive CBNAAT while majority of those with
normal chest x-ray had negative CBNAAT.

To Study Haematological Profile In Patient Of Pulmonary Tb With And Without Hiv Co- Infection

Dr. Mahendra Tilkar, Dr. UmeshPratap Singh, Dr. AnkitAnoop Maravi, Dr. Praveen K. Baghel

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1709-1718

Background: TB and HIV form a lethal combination, as each fuels the progress of the other in the infected patients. This study assessed the haematological parameters of pulmonary tuberculosis (PTB) patients with and without HIV infection attending the shyam shah medical college, Rewa. Aims: To study hematological parameter namely Hb (Hemoglobin), total RBC count, Total WBC count, ESR (Erythrocyte Sedimentation Rate) and platelets in pulmonary tuberculosis. Methods: To analytical study of all 120 (TB with HIV 60 / TB without HIV 60)  TB patients who were attending Department of Medicine, Shyam Shah Medical College, Rewa (M.P.). And patientsrefered from Anti-retroviral therapy centre, with sputum positivity for AFB (acid fast bacillius).Results: In our study, 83.3% were males and 16.6 % were females in the TB with HIV group. 70% of patients were in the age group of 25 – 45 years in the TB with HIV group, whereas 86.6% of patients were in age group of 25 – 45 years in the TB without HIV. 90% of patients were underweight with BMI less than 18.5, in TB with HIV group, and 73.3% of patients were underweight in TB without HIV group. 80% were anemic in the TB with HIV and 66.6% were anemic in TB without HIV group. 63.4% of patients with TB and HIV had thrombocytopenia, whereas only 10% of patients had thrombocytopenia in TB without HIV group. patients with tuberculosis per se have increased ESR count, whereas TB-HIV coinfection has drastically reduced the ESR count. Among patients with TB and HIV 83.3% of patients had ESR less than 60 mm/hr., whereas 96.6% of TB without HIV patients had ESR greater than 60 mm/hr. since, ESR is a marker of chronic inflammatory states like TB and HIV is a immunosuppressive state, the co-infection of TB with HIV has drastically reduced ESR values in these patients.Conclusion:ESR values are drastically reduced in TB patients with HIV, rather TB patients per se. hence, an ESR less than 60 mm / hr in pulmonary tuberculosis patients should arouse a suspicion of underlying immunocompromised state.