Online ISSN: 2515-8260

Keywords : Dengue fever


DENGUE AND CHIKUNGUNYA OUTBREAKS IN TERTIARY CARE HOSPITALS A RETROSPECTIVE STUDY

G Ratna Prabha, S Rajeshwar Rao

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 687-695

Dengue and chikungunya are two arboviral infections that are common in tropical countries and are spread by aedes mosquitoes. A retrospective study was conducted from June 21 to June 22 to determine the prevalence of these diseases at Gandhi Hospital Secunderabad, Telangana. NIV's IgM antibody capture ELISA kits were used to test for chikungunya.SDdiagnostics performed dengue NS1 antigen testing using ELISA. There were 2981 samples for dengue NS1 antigen, of which 114 (3.8 percent) were positive, and 4822 samples for IgM, of which 618 (12.8 percent) were positive.The number of chikungunya samples received was 4711, with 376 (7.9%) being positive. The age group most commonly affected by dengue was 40–60 years old (37.7 percent) and for chikungunya, 21–40 years (58.7 percent). In terms of gender distribution, males accounted for 58.7 percent of dengue infections and females for 55.7 percent of chikungunya infections, respectively. Dengue infectivity increased the most in September (17.4%) and October (17.11%), while chikungunya infectivity increased the most in September (9.5%) and November (10%). But early detection and treatment, as well as controlling vectors toprevent  the spread of disease, would be good for the community and society as a whole.

Liver Function Tests to Predict the Severity of Dengue Fever in Serologically Positive Children Below 18 Years of Age

Janardhan Reddy Pulluru, Suraboina Satishkumar, Gajula Ravi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10404-10413

Background:Dengue fever presents with a diverse clinical spectrum. Although liver is
not a major target organ, hepatic dysfunction is a well recognized feature. In this study
we attempted to study the pattern of hepatic involvement in children with dengue and
its association with disease severity.
Materials and Methods: This was a cross sectional study conducted at during the period
of 1 year. Children <18 years of age with dengue Ns1 Ag and IgM positive were
included in this study. After obtaining informed consent, a pre structured proforma was
used to record the relevant information from each subject. After detailed clinical
examination and haematological investigation children were categorized into three
groups as dengue fever with no warning signs(DNWS), dengue fever with warning
signs(DWWS) and severe dengue fever(SDF) according to WHO classification.
Statistical analysis was done to know the strength of association between different
clinical and biochemical variables and outcome of the disease.
Results: The mean age of the study population was 8.65 years with male preponderance.
The mean total bilirubin, serum albumin, SGOT, SGPT, ALP, PT and INR were 0.76
mg/dl, 3.8g/dl, 233.18U/L, 118.15U/L, 200.65 U/L, 12.9s and 1.09 respectively. The mean
SGOT was significantly higher than SGPT. The degree of deranged LFTs was
significantly more in SDF group than DNWS and DWWS groups. Serum albumin was
significantly decreased in children with SDF group correlating with disease severity,
prognosis and outcome.
Conclusion: Hepatic dysfunction was present in all forms of dengue infection, with
SGOT rising significantly more than SGPT. All biochemical liver parameters were
significantly deranged in patients with severe dengue fever indicating prolonged illness
and poor prognosis.

An Observational Study to Correlate the Clinical Profile with Laboratory Investigations and Radiological Findings in Dengue Fever at Tertiary Care Center

Ramesh Chand Sharma, Mamta Meena

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10467-10472

Background: The demographic pattern and the trend of disease (dengue fever) are
largely changing everyyear through the past decade.Early recognition and prompt
initiation of appropriate management is vital. The aim of this study to correlate the
clinical profile with laboratory investigations and radiological findings in dengue fever
at tertiary care center.
Materials& Methods: A cross sectional study done on 50 children less than 12 years of
age with clinical signs and symptoms of Dengue- any acute febrile illness in department
of Pediatrics, RUHS College of Medical Sciences, Jaipur, Rajasthan, India during one
year period. For all suspected dengue fever, the IgM ELISA qualitative test was done at
our hospital. Children positive for IgM dengue were taken up for study and followed up
for clinical profile.Labinvestigations carried out in these patients include CBC,
Haemoglobin, renal functiontest, Liver function test and Dengue IgM serology. Chest X
ray was taken todemonstrate pleural effusion. Children positive for IgM were followed
up for the clinicalprofile and outcome.
Results: Our study showed that the larger number of cases was in 6 to 12 years.).Males
were affected slightly more than females in total and also insubgroupsexceptin DHF
III.Itwas not significant (P>0.05).The mean duration of fever was 6.23 days.Pleural
effusion was seen 6 patients, of which more cases in dengue feverwith warning sign.
Abdominal tenderness was seen in 46% of cases, highest in denguefever with warning
signs and lowest in mild dengue which is statistically significant.Ascites was seen in 20
% of cases, highest in dengue fever with warning signs andDHF IV. Hepatomegaly was
seen in 30%, highest in DHF IV and lowest in mild dengue which is statistically
significant. The splenomegaly was seen in 4% of cases. AST was elevated in 36% of
cases. More in DHFIII & DHFIV cases, but it is not statistically significant. ALT was
increased in 30% of cases. More elevated cases are in DHFIII which was also not
significant.

A SIGNIFICANCE OF LIVER FUNCTION TESTS TO PREDICT THE SEVERITY OF DENGUE FEVER IN SEROLOGICALLY POSITIVE CHILDREN BELOW 18 YEARS OF AGE

Madepelly Aditya

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11761-11770

Background:Liver dysfunction in dengue varies from mild injury with elevation of transaminases to severe hepatocyte injury. Despite hepatocytes are not a major target, hepatic dysfunction is the recurrent feature. Predictive hepatic serum markers represent a solution for the dynamic care of serious dengue and predicting disease prognosis. In the present study we pursued to mold the mode of hepatic involvement in children with dengue and its association with seriousness of disease.
Materials and Methods: This was a cross sectional analytical study conducted at Department of Pediatrics, Govt Medical College &hospital during the period of 18 months from October 2019 April 2021 on 120 children under 18 years of age diagnosed with dengue positive and similar age and sex matched controls were included in this study. After obtaining informed consent, Patient demographics, presenting symptoms, clinical signs, laboratory parameters such as complete blood count, serum AST, serum ALT, ALP, total and direct bilirubin; serum albumin levels were collected. P-value <0.05 and CI 95% were considered significant in all correlation analyses between transaminases and platelet count.

Evaluation of cardiac biomarkers in predicting severity of dengue fever

Dr. Chetan Kerur, Dr. Khizerulla Sharief, Dr. Mohana , Dr. Pragalatha Kumar

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2508-2513

Dengue virus will affect several systems of the body. Myocardial involvement may be the direct effect of the virus itself or may be due to cytokine production. Myocarditis has a varied presentation, it may be clinical or subclinical. Myocarditis can present as cardiac failure, Electrocardiogram (ECG) changes (sinus bradycardia, sinus tachycardia, T wave inversion), 2 D Echocardiography changes (reduced ejection fraction) and elevated cardiac enzymes (Troponin T, CPK, CPK-MB, LDH, N terminal-BNP). The study was approved by the institutional ethical committee. Informed written consent was obtained from the parents of each patient before enrollment. History and examination findings were recorded in a pre-structured proforma. Children with clinically diagnosed dengue fever (WHO criteria) & serologically confirmed and admitted cases between the age group of 2months to 18 years formed the study group. In 110 biomarker positive cases, 32(17.3%) had a shock, 14 (7.6%) had bleeding manifestations, 78(42.2%) cases had elevated SGOT and SGPT and PT and aPTT elevated in 84(45.4%) and 44(23.8%) cases respectively.

ASSESSMENT OF THE KNOWLEDGE ABOUT SYMPTOMS AND SIGN OF THE DENGUE FEVER IN THE PRIMARY HEALTH-CARE MEDICAL PRACTITIONER’S IN MAKKAH AL-MOKARRAMAH CITY AT SAUDI ARABIA

Najeeb Hamid Alsahafi, AbdullahBurayk Mabruk Alyuobi, Hasan Mohamed Alasmari, Helal Ghali AL harbi, Abdulmohsen Rashid Alotaibi, Mohammed Yahia Almalki, Asma Naif Alosaimi, Alaa Mohammed Askar, Bandar Mulfi Lafi Alluqmani, Fahad Mohammed Allehyani

European Journal of Molecular & Clinical Medicine, 2019, Volume 6, Issue 1, Pages 182-195

Background:
Dengue has emerged as a major public health problem, with increasing incidence and widening geographic spread over recent years. It is a vector-borne disease that is transmitted from person to person by mosquitoes. Dengue is a mosquito-borne infection found in tropical and subtropical regions around the world. In recent years, transmission has increased predominantly in urban and semi urban areas and has become a major international public health concern.Since 1994, Makkah province became a dengue-endemic area with high rate of dengue infection during, spring and early summer. The primary-care physician plays a key role in dengue diagnosis, management, and prevention.
Aim of the study:The study aimed to assess the level of knowledge about symptoms of the dengue fever in the primary health-care medical practitioner’s in Makkah Al-Mokarramah city at Saudi Arabia
.Methods: Across sectional descriptive study conducted among including medical practitioner’s  in selected primary health–care centers in Makkah Al-Mokarramah city, during the October to December, 2018, the Sample size of medical practitioners . Our total participants were (300)
.Results: This table shows the majority of participant (43.0%) have average level of knowledge about symptoms of dengue fever followed by (36.3%) of participant high while Range(0-10) and Mean ±SD(6.387±2.323). Regarding knowledge about signs dengue fever, that majority of participant (48.3%) have average level of knowledge followed by (38.3%) of participant have an high level of knowledge while Range(1-11) and Mean ±SD(7.877±2.052). Regarding the participant total level of knowledge about dengue fever, about (41.4%) have average level followed by (38.3%) have average level of knowledge while Range(3-21) and Mean±SD(14.263±4.021)
Conclusion: This review highlights the need for revealed major gaps on knowledge about symptoms of the dengue fever in the primary health-care medical practitioner’s related to dengue Makkah. primary health-care medical practitioner’s working in primary Health care need training and regular supervision to improve their knowledge on the about symptoms of the dengue fever. The results of this study provide a useful opportunity to identify strengths and areas in need of improved, knowledge about symptoms of the dengue fever in primary-care management of dengue.