Online ISSN: 2515-8260

Keywords : Gabapentin


Evaluation of the effectiveness of gabapentin in the management of postoperative pain after total hip arthroplasty

Dr. Karunakar Dwivedi, Dr. Ashutosh Singh, Dr. Manish Maheshbhai Khokhar

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1482-1486

Background: It was well reported that gabapentin has a role in the management of neuropathic pain. However, substantial evidence for the same was sparse.
Objective: The present study was undertaken to evaluate the effectiveness of gabapentin in the management of postoperative pain after total hip arthroplasty.
Materials and methods: A total of 50 patients diagnosed with sepsis and aged more than 18 years including both males and females were part of the study after obtaining the written, voluntary informed consent. Unwilling participants were excluded from the study. Patients with any severe complications were also excluded from the study.
Results: The majority of the participants were males with 60 % and females were 40%. The majority of patients were having pain scores of 7-9 before the intervention in the control group. The majority of the patients are in pain scores of 7-9 after ibuprofen in the control group. Table no 5 presents the distribution of the intervention group participants according to the pain scores after intervention. The majority of the patients were in pain scores of 1-3 after the administration of gabapentin.
Conclusion: The study results confirm that gabapentin has a significant effect on the management of pain after the surgery of the knee and hip. The study recommends further detailed study in this area to recommend gabapentin in the management of pain.

Oral gabapentin (600mg) versus oral pregabalin (75mg) for orthopedic surgery under spinal anesthesia: Hemodynamic changes

Dr. Rahul Bankapur, Dr. Preeti Lamba, Dr. Rahul Jain

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 321-326

The myelinated A δ (sharp pain, first pain) peripheral nociceptors and unmyelinated C
nociceptors (delayed pain, second pain) respond to strong mechanical, thermal, chemical
stimuli that act as transducers, converting chemical, mechanical or thermal energy at the site
of stimulus to electrical activity, which are conducted to the dorsal horn of CNS. Based on
previous study by Usha Bafna et al., sample size was calculated to be 30 patients, to be
randomly included in each group to demonstrate a 40% difference in duration of analgesia
with a power of 0.8 and type-1 error of 0.05. To allow for study error and attrition, 35 patients
were included in each group. In Group A, 3 (8.57%) patients and in Group B, 4 (11.42%)
showed hypotension that is mean SBP was less than 20% of the base line, were as none of
patients in either group showed hypertension that is more than 20% of the baseline SBP
(intraop and postop). There was no statistically significant difference between two groups P
value (0.6903).

To study the comparison of functional outcomes between pregabalin versus gabapentin in Cases of Low Back Ache with radiculopathy

Dr.Akashdeep Singh,Dr.Saurabh Aggarwal,Dr.Tarun Behal

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1872-1875

Aims & Objectives: Millions of people have low back pain, which causes more disability
than any other health condition. The present study was planned for comparing the
functional outcomes between pregabalin versus gabapentin in Cases of Low Back Ache
with radiculopathy.
Materials & methods: A total of 100 subjects with presence of low back ache with
radiculopathy were enrolled. Clinical and MRI examination of all the patients was done.
All the 100 patients were divided into two study groups with 50 patients in each group as
follows: Gabapentin group and Pregabalin group. Capsule pregabalin 75 mg one time a
dayorally and tablet gabapentin 300 mg one timea day was given in the respective groups.
Both drugs were given at night time. Pain intensity was assessed at the start of study i.e. at
baseline (0 week), at 1 month and three months using VAS. Complications were recorded
on each visit. All the results were recorded and analysed by SPSS software.
Results: Mean VAS at baseline, one month and three months among patients of group
Pregabalin was 8.91, 6.96 and 3.16 respectively. Mean VAS at baseline, one month and
three months among patients of group Gabapentin was 8.12, 6.43 and 3.58 respectively.
While making intra-group comparison, significant results were obtained. However; while
comparing the mean VAS between the two study groups, non-significant results were
obtained at different time intervals. Sedation as a side effect was significantly more
common in Pregabalin group.
Conclusion: Gabapentin was better in comparison to pregabalin in having fewer side
effects.