Online ISSN: 2515-8260

Keywords : haemodynamic responses

Effect of Dexmedetomidine Infusion on Haemodynamic Responses to CapnoperitoneuminPatients Undergoing Elective Laparoscopic Cholecystectomy under General Anaesthesia

Dr. Prashantha Kumar HM, Dr. Usha Saha, Dr. Radhika Agarwala

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1896-1905

Dexmedetomidine (Dexmed) belongs to the imidazole subclass of α2 receptor agonists,
similar to clonidine. It is a potent and highly selective α2 adrenoreceptor agonist,approved
by FDA in 1999 for use in humans for analgesia and sedation. It has a greater affinity for
α2 receptors over α1 (1620:1). Its α2/α1 selectivity ratio is eight times higher than that of
clonidine. All patients underwent a thorough preanaesthetic check-up. Written informed
consent was obtained from each patient after explaining the procedure in a language that
the patient understood. Patients were kept NPO from midnight and advised Tab. Diazepam
(0.1-0.15 mg/kg) and Tab. Rantac 150 mg night before and at 6 AM on the morning of
surgery with sips of water. The mean Etsevo in Group D was 0.29±0.02% and in Group C, it
was 0.31±0.01% upto 5 mins after intubation. Thereafter, it showed an increasing trend in
both the groups.From 5 minutes post insufflation, mean Etsevo (0.48±0.20%) was higher in
Group C as compared to Group D (0.33±0.11%). The difference was very highly significant
upto about 30 minutes of CO2 insufflation. There after mean Etsevo (0.32±0.01%) was
comparable in both the groups till the end of surgery.