Online ISSN: 2515-8260

Keywords : OSA

Effect Of CPAP, CPAP With Lifestyle Changes And CPAP With Pranayama On Sleep Pattern In Obese Diabetic Subjects With Obstructive Sleep Apnea

Shah VK; Badade ZG; Banerjee A; Rai S; More K

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 987-998

Background: The prevalence at an apnea-hypopnea index (AHI) of 5 or more occurrences per hour was greater in males (9%-38%) than in the general population. The prevalence of this trait rose with age, reaching as high as 90% in males and 78% in women among the elderly. Obstructive sleep apnea has been associated to metabolic dysregulation independent of obesity and OSA, and sleep fragmentation is a major consequence of OSA. 
Method: Inpresent study246 subjects received polysomnography (PSG) and among them 192 assessed for CPAP titration. 78 participants were removed due to inclusion criteria, CPAP intolerance, refusal to participate, those who can't afford treatment, etc. The remaining 114 subjects were 61 obese non-diabetics and 53 obese type 2 diabetics. These 53 obese diabetic subjects were divided into 3 groups: CPAP group, CPAP with Lifestyle changes and CPAP with Pranayama group. Follow-up was done after six-month.
Result: All study groups had lower AHI scores. Sleep efficiency % increased across all trial groups. All research groups' stage I and Stage II sleep % were decreased and demonstrated increase in time in Stage III. All groups experienced more REM sleep, Improved SPO2 % and lower Epworth Sleepiness Scale (ESS) scores.
Conclusion: The sleep pattern improved across all the different sleep stages. Using CPAP in conjunction with these two interventions not only enhances the success rate of treating OSA, but also shortens the overall time necessary for therapy.

Retrospective Evaluation of Hypertrophy of Salpingopharyngeal Fold in OSA at a Tertiary Care Hospital

Jitendra Pratap Singh Chauhan, Raveendra Singh Rajpoot, Ajai Kumar, Somendra Pal Singh, Sunil Kumar Singh Bhadouria

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5769-5774

Introduction: The most common cause of sleep disordered breathing is reported to be
the obstructive sleep apnoea. It could possibly lead to serious physiological, social and
few neurocognitive disorders. Since the reported prevalence rate is higher, OSA has
often been misdiagnosed and unnoticed.
Materials and Methodology: This study was designed as a retrospective analysis of
patients reported with the polysomnographic confirmation of obstructive sleep apnoea.
Those patients included in this study had undergone Drug Induced Sleep Endoscopy
(DISE) using flexible video rhino-laryngoscope under BISTM monitoring which is
reported to be a valid bi-spectral index monitor in measuring the depth of sedation.
Drugs like dexmedetomidine and midazolam was initially used in titrating doses in
order to maintain BISTM score in the range of 60–80. The DISE video data of 189
patients was assessed by two ENT surgeons individually. Each of them was instructed to
grade the hypertrophy of the salpingopharyngeal fold as Grade 0 having normal
anatomy, Grade 1 being hypertrophy causing partial obstruction and Grade 2 being
hypertrophy which is reportedly responsible for complete obstruction of lateral
pharyngeal wall. Data of 160 patients of the 189 had 100% agreement between the two
expert surgeons while grading the hypertrophy. Thus, the data of 160 patients was
included in the study for further comparison and analyses. The patient’s data was
divided into two groups. Group 1 included 110 patients who had isolated palatal level
obstruction whereas group 2 constituted 50 patients affected with sleep apnoea due to
obstruction at multiple levels BMI of the patient was calculated. There was no
significant difference between the two groups for age (p<0.05), AHI (p <0.05) and BMI
(p<0.05) Shapiro Wilks test of Normality was applied to check for the distribution of the
data, non-normal distribution the data was subjected to non-parametric analyses.


Dr. Sowmya Mohan Kumar; Dr. Saravanan; Dr. Kannan Sabapathy, MDS

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 1706-1714

Obstructive sleep apnea is the most common sleep related breathing disorder that is characterized by recurrent episodes of complete or partial obstruction of airway leading to reduced or absent breathing during sleep. Most common trigger factors are obesity, anatomical defects in the pharynx and reduction in airway which disrupts routine sleep cycle and results in reduced quality of life. This review article describes the sequalae of events due to OSA and importance in the diagnosis and management of OSA by orthodontists.