Online ISSN: 2515-8260

Keywords : tranexamic acid

Prophylactic tranexamic acid in reducing blood loss during and after the lower segment caesarean section: Adverse effects and complications

Dr. Usharani N, Dr. Bhagyajyoti, Dr. Chandrashekar K

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 5, Pages 200-204

PPH is one of the major cause of maternal mortality and morbidity by altering hemodynamic stability. Primary PPH is excessive blood loss within 24 hours, Secondary PPH is excessive bleeding in the period from 24 hours after delivery till puerperium. Among 100 primigravida, 50 were taken as study group i.e., Group A which involves intervention by administrating IV Tranexamic acid 1 gm and 50 as control group i.e., Group B without intervention. In our study group most common indication was fetal distress i.e., 68% in cases and 76% in controls and p value is 0.126 (> 0.05), which means both groups were comparable. Nausea among 10 cases, Head ache among 12 cases and vomiting among 7 cases had occurred. There were no evidence of complications like thromboembolism

A randomized comparative study to assess blood loss in patients undergoing total hip arthroplasty with and without the use of tranexamic acid

Dr. Saurabh KP, Dr. Sunkappa SR, Dr. Karthik B, Dr. Rameshkrishnan K, Dr. Ramesh Krishna K

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2380-2387

Background: Total hip arthroplasty could be associated with major intra-operative as well as post-operative blood loss. Post-operative anaemia is a recognized complication which can prolong hospital stay, delay rehabilitation and is poorly tolerated by elderly patients. Blood transfusion carries the risk of infections, anaphylaxis, etc. We examined whether tranexamic acid given before and after total hip arthroplasty reduces intra-operative, post-operative and total operative blood loss and whether the need for post-operative blood transfusion is reduced.
Materials & Methods: A total of 40 patients were included in this study. Group A (n=20, study group) received I.V tranexamic acid (15mg/kg body weight) infusion 10 minutes before incision. 4 hours later, 10mg/kg body weight I.V tranexamic acid was given. Group B (n=20, control group) did not receive any anti fibrinolytic agent. The amount of blood loss, post-operative drop in haemoglobin and the amount of blood transfused was recorded in each case.
Results: Tranexamic acid significantly reduced intra-operative blood loss by 35.68% and total operative blood loss by 22.87% with a 30% reduction in blood transfusion rates compared to the control group. There was no significant effect on post-operative blood loss, duration of surgery or length of hospital stay.
Conclusion: Tranexamic acid when administered perioperatively significantly reduces the operative blood loss in primary total hip arthroplasty surgery with minor side effects. Thus, it can be used effectively in patients undergoing primary total hip arthroplasty to reduce intra-operative blood loss and the need for blood transfusions.

Efficacy of tranexamic acid in reducing perioperative blood loss in lower limb orthopaedic surgeries: A prospective randomised single blinded study

Dr. Tulaja Prasad PV, Dr. Anilkumar T Bennur, Dr. Pragadeeshwaran G

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 2024-2028

  Introduction: Tranexamic acid (TXA) is a lysine analog that exhibits an anti-fibrinolytic effect by directly   preventing the activation of plasminogen as well as inhibiting activated plasmin from degrading fibrin clots.
Objectives: The objective of the study is to know the effect of Tranexamic acid in reducing intraoperative and postoperative blood loss in patients undergoing lower limb orthopaedic surgeries and to study the effect of drug on perioperative hemodynamic.
Materials and Methods: A prospective randomised control study was done in Basaveshwara Medical College and Hospital, Chitradurgato know the effect of Tranexamic acid in reducing intraoperative and postoperative blood loss in patients undergoing lower limb orthopaedic surgeries.
Results: Who received tranexamic acid had roughly 170ml lesser intra-operative blood loss than the control subjects and this difference was statistically significant (p<0.05).
Conclusion: Perioperative blood loss and the need for transfusion in major orthopedic surgeries can be effectively reduced by using Tranexamic acid.