Online ISSN: 2515-8260

Keywords : melatonin


LARYNGOSCOPY INTUBATION AND EXTUBATION ARE AFFECTED BY MELATONIN: A PROSPECTIVE STUDY

Dr. Adithi Devi E, Dr. M Bhawathi, Dr. Pavani Kalyanam, Dr. PV Shiva

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 3209-3216

Aim and objectives: Hypertension and increased heart rate are prevalent during laryngoscopy and tracheal intubation. Acute LV failure, dysrhythmias, IC haemorrhage, pulmonary edoema and myocardial infarction are all possible complications. Patients with hypertension had a heightened pressor response, despite being preoperatively normalized with anti-hypertensive medication. The purpose of this research is to see if melatonin is more effective than a placebo at reducing the Haemodynamic reactions to laryngoscopy and endotracheal intubation. Research into the effects of melatonin on extubation response and intraoperative hemostasis is also a goal.
Materials and Methods: This study took place between June 2020 and May 2022 at Public Sector Tertiary care center and the Government Ear, Nose, and Throat Hospital. There were a total of 60 participants in the study. They split up into pairs. Melatonin 6 mg capsules (Group M) and a placebo (Vitamin D3) were given to Group C, both to be taken 120 minutes before to surgery.
Results: The melatonin group had a considerably lower increase in HR compared to the control group during laryngoscopy and intubation (P0.0029). The melatonin group also had considerably decreased heart rate variability during and after extubation compared to the placebo group. After induction, during laryngoscopy and intubation, and for the first 10 minutes after tracheal intubation, systolic blood pressure was considerably lower in the melatonin group. Systolic blood pressure was considerably lower in the melatonin group after surgery. Compared to the placebo group, the SBP of those receiving melatonin prior to, during, and after extubation dropped dramatically. The melatonin group had lower diastolic blood pressure than the placebo group throughout laryngoscopy and intubation, as well as after 1 minute, 5 minutes, and 10 minutes post-intubation. The intraoperative DBP in the melatonin group was substantially lower. DBP was likewise considerably lower in the melatonin group after extubation. As a result, the melatonin group had considerably lower mean arterial pressure (MAP) during the intraoperative time. There was a huge discrepancy
between the groups during the extubation process and immediately afterward.
Conclusion: The results of the study show that the hemodynamic reactions to laryngoscopy, intubation, and extubation can be reduced by giving the patient 6 milligrammes of exogenous melatonin orally 120 minutes before intubation. In addition, it aids in keeping intraoperative hemodynamics steady.

A Prospective Study Evaluating the Correlation of Sleep Pattern, Melatonin Secretion and Obesity

Annie Sandhu1, Dharminder Singh2, Akashdeep Singh2, Kuldip Singh Sandhu3, Savvy Aujla4 .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 3174-3180

Background: The present study aims to assess correlation of sleep patterns, melatonin secretion, and obesity.
Materials and Methods: One hundred and twenty-two subjects in age ranged 11-17 years of both genders were subjected to fasting blood glucose, insulin level, uric acid, lipid profile and renal function test measurement. Insulin resistance and level of melatonin with enzyme-linked immunosorbent assay (ELISA) were determined.
Results: There were 30 males and 22 females without insulin resistance (IR) and 40 males and 30 females with IR. There were 6 prepubertal, 12 pubertal, and 34 postpubertal subjects without IR and 8 prepubertal, 15 pubertal, and 47 postpubertal subjects with IR. The mean Body Mass Index (BMI) (Kg/m2) was 29.1 and 34.2, Systolic Blood Pressure (SBP) (mm Hg) was 128.6 and 134.2, Diastolic Blood Pressure (DBP) (mm Hg) was 66 and 72, total cholesterol (TC) (mg/dl) was 160.2 and 164.8, triglyceride (TG) (mg/dl) was 70 and 104.2, High Density Lipoprotein (HDL) (mg/dl) cholesterol was 54.2 and 46.8 and Low-density lipoprotein (LDL) (mg/dl) cholesterol was 92 and 98 in subjects without IR and in subjects with IR respectively. The mean uric acid was 5.3 mg/dl in subjects without IR and 5.9 mg/dl in subjects with IR. The mean MT6s:Cr (Melatonin 6s: Creatinine) ratio was 31.4 in subjects without IR and 27.4 in subjects with IR. The difference between both groups was found to be significant (P< 0.05).

Serum melatonin levels alter in type 2 diabetes mellitus individuals along with IL-2, IL-15 and TNF-α

Lingidi Jhansi Lakshmi, Savita Rathore, Muhamed Faizal, Faiz Noor Khan Yusufi, Doddigarla Zephy

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 2452-2462

Background & Aims: According to our knowledge, there is a lack of sample study in this specific region of our country, regarding the relationship of melatonin with anti- and pro-inflammatory cytokines. Therefore, the novelty of this present study, we have taken the opportunity to determine the relationship of melatonin with anti- (IL-2) and pro-inflammatory (IL-1β, IL-15, and TNF-α) cytokines in 2DM subjects. Methods: After obtaining the approval from the institutional ethical committee, the present study was commenced. The study was conducted in Department of Biochemistry, Malwanchal University, Indore, India. Total two hundred and thirty individuals are recruited in to this present study after the approval from Institutional ethical committee. Age & sex matched one hundred and fifteen human non-2DM individuals were taken into healthy control group. One hundred and fifteen subjects, on treatment for 2DM were included in second group. Results: Statistical significant differences were observed in serum melatonin levels and post-prandial blood glucose when compared between 2DM subjects and healthy controls. We also observed statistical significances in the serum values of IL-2, IL-15, IL-1β, and TNF-α when compared between 2DM subjects and healthy controls. The study observed steady upward positive correlation between melatonin and IL-2 levels in healthy controls. On the contrary the study observed a negative association between serum melatonin and IL-15 levels and also between melatonin and TNF-α in 2DM subjects. Conclusion: The authors conclude from the study that alterations in the study parameters in 2DM group are due to altered balance between anti-inflammatory and pro-inflammatory cytokines production. This altered balance is due to low production of melatonin in 2DM subjects than healthy controls.